结肠癌筛查和预防的生物数学评估-猫眼课题宝

结肠癌筛查和预防的生物数学评估

批准号：

8204911

负责人：

Georg E. Luebeck

金额：

$27.16万

依托单位：

FRED HUTCHINSON CANCER RESEARCH CENTER

依托单位国家：

美国

项目类别：

财政年份：

2005

资助国家：

美国

项目状态：

已结题

起止时间：

2005-03-01 至 2013-12-31

来源：

https://reporter.nih.gov/project-details/8204911

关键词：

Adenomatous Polyps Adult Age Agreement Algorithms American College of Radiology Imaging Network American College of Surgeons Anatomy Archives Aspirin Attention Back Belief Benign Biological Biological Process Birth Cancer Detection Cancer Etiology Cancer Intervention Cancer Model Categories Cells Cessation of life Characteristics Chemoprevention Church Classification Clinical Clinical Chemoprevention Clonal Expansion Collaborations Colon Colon Carcinoma Colonoscopy Colorectal Colorectal Cancer Complement Computer software Cost-Benefit Analysis Costs and Benefits Data Data Analyses Data Set Data Sources Dependence Detection Development Diagnosis Diagnostic Neoplasm Staging Distal Distant Dose Epidemiologist Epidemiology Evaluation Excision Fecal occult blood Flexible fiberoptic sigmoidoscopy Folate Folic Acid Gatekeeping Gender Generic Drugs Genes Genetic Goals Grant Growth Hand Health Histologic Image Incidence Individual Intervention Joints Lesion Letters Life Link Lung Malignant - descriptor Malignant Neoplasms Malignant neoplasm of pancreas Markov Chains Medical Surveillance Memorial Sloan-Kettering Cancer Center Modality Modeling Molecular Mutation Natural History Nature Optics Outcome Ovarian Pathway interactions Patients Phase Phenotype Placebos Polyps Population Premalignant Premalignant Neoplasm Prevention Preventive Intervention Process Public Health Radiology Specialty Randomized Recommendation Rectal Neoplasms Registries Relative (related person)Reporting Residual state Resources Risk Risk Factors Screening for cancer Screening procedure Sensitivity and Specificity Sigmoidoscopy Site Staging Supplementation Surveillance Modeling Techniques Time Tumor Promotion Tumor stage United States National Institutes of Health Validation Work adenoma base cancer risk case control college colon cancer family registry colorectal cancer registry colorectal cancer screening computer framework computerized tools cost data sharing epidemiology study follow-up genetic epidemiology hazard high risk improved interest member mortality parent grant population based pre-clinical prevent programs sex risk simulation tool treatment duration trial comparing tumor tumor initiation tumor progression working group

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中文摘要

翻译

项目摘要尽管有大量的实验、临床和流行病学数据帮助确定了重要的遗传成分和途径在结直肠癌（CRC），CRC仍然是第二大原因与癌症相关的死亡，预计2008年仅在美国就有近50，000人死亡。因为结直肠癌主要发生在良性的前体（主要是腺瘤性息肉），这些前体很可能寄居在大肠癌中。多年前，他们变成恶性，CRC可以预防很大程度上通过筛查和及时干预这次更新的目标是通过对自然界的生物数学描述， CRC的病史，如何最有效地应用筛查和干预措施以降低死亡率与CRC相关

英文摘要

Project Summary In spite of the wealth of experimental, clinical and epidemiological data that have helped identify important genetic components and pathways in colorectal cancer (CRC), CRC continues to be the second leading cause of cancer associated death, with close to 50,000 deaths predicted for the year 2008 in the US alone. Because CRC arises predominantly in benign precursors (mainly the adenomatous polyps), which are likely to sojourn for many years before they turn malignant, CRC can be prevented largely through screening and prompt intervention. The goal of this renewal is to further explore, via a biomathematical description of the natural history of CRC, how screening and interventions can be applied most effectively to reduce the mortality associated with CRC

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