Biomedical adhesives with precisely engineered surface topography and chemistry

描述（由申请人提供）：对于能够牢固粘合软组织和切口以促进愈合并最小化炎症的粘合剂存在显著的医疗需求。这些材料可以潜在地减少手术时间、组织处理，并减轻并发症，如感染。虽然存在许多组织粘合剂，但由于诸如机械性能不足、炎症增加和难以应用于某些伤口几何形状等限制，它们的应用受到限制。我们最近开发了一种具有可调机械、降解和粘合性能的生物相容性纹理组织胶带。针对组织的功能测试显示最大粘附强度为0.8 N/cm 2，但为了将这些材料转化为医疗应用，需要约5-15 N/cm 2的粘附强度。 在这项提案中，我们的目标是开发一种粘合力强，可应用于各种组织的粘合剂。我们将揭示制造具有明确表面形态和化学性质的生物界面粘合剂而不会引起显着炎症反应所需的基本科学和工程原理。通过增强我们现有纳米结构胶带的粘附力，并通过阐明影响粘附到不同组织的机制，拟议的研究将为发现新科学提供一个潜在的平台，从而为外科手术器械带来许多实用和有用的补充。具体而言，一类新的强粘附性微/纳米纹理生物材料将通过控制微和纳米尺度上的生物相容性聚合物的表面特征，并通过系统地开发如何地形，孔隙率和化学影响粘附到生物组织的理解。通过使用柔软的柔性材料，纹理化表面应容易地符合不规则形状的表面，例如软组织，从而使界面处的分子相互作用最大化。

DESCRIPTION (provided by applicant): There is a significant medical need for an adhesive that can bond strongly to soft tissues and incisions that facilitates healing and minimizes inflammation. These materials can potentially reduce operating time, tissue handling, and mitigate complications such as infection. While numerous tissue adhesives exist, their applications are restricted due to limitations such as insufficient mechanical properties, increased inflammation and difficulty in application to certain wound geometries. We have recently developed a textured tissue tape that is biocompatible with tunable mechanical, degradation and adhesive properties. Functional testing against tissue showed maximum adhesion strength of 0.8 N/cm2, but in order to translate these materials to medical applications, adhesion strengths of ~5-15 N/cm2 are required. In this proposal, we aim to develop an adhesive that bonds strongly and can be applied to a variety of tissues. We will reveal the fundamental scientific and engineering principles required to fabricate biologically interfacing adhesives with well-defined surface morphologies and chemistries without inducing a significant inflammatory response. Through enhancing the adhesion of our existing nanostructured tapes and through elucidating mechanisms that impact adhesion to different tissues, the proposed research will provide a potential platform for discovery of new science that leads to many practical and useful additions to the surgical armentarium. Specifically, a new class of strongly adhesive micro/nano textured biomaterials will be developed by controlling the surface features of biocompatible polymers on the micro and nanoscale, and by systematically developing an understanding of how topography, porosity, and chemistry influence adhesion to biological tissues. Through using soft, flexible materials, the textured surfaces should easily conform to irregularly shaped surfaces, such as soft tissue, thereby maximizing molecular interactions at the interface.