Biomedical adhesives with precisely engineered surface topography and chemistry

描述(申请人提供)：医学上非常需要一种粘合剂，这种粘合剂可以牢固地粘合在软组织和伤口上，促进愈合并最大限度地减少炎症。这些材料可能会减少手术时间，减少组织处理，并减少感染等并发症。虽然存在大量的组织粘合剂，但由于机械性能不足、炎症增加以及难以应用于某些伤口几何形状等限制，它们的应用受到限制。我们最近开发了一种质地组织带，它具有可调的机械、降解和粘合性能，具有生物兼容性。针对组织的功能测试显示最大粘接强度为0.8N/cm2，但要将这些材料转化为医疗应用，需要~5-15N/cm2的粘接强度。在这项提案中，我们的目标是开发一种粘结力强的粘合剂，可以应用于各种组织。我们将揭示制造生物界面粘合剂所需的基本科学和工程原理，这些粘合剂具有明确的表面形态和化学成分，而不会引发显著的炎症反应。通过增强我们现有纳米结构胶带的粘附性，并通过阐明影响对不同组织粘附性的机制，拟议中的研究将提供一个潜在的平台，用于发现新的科学，从而为外科医疗设备带来许多实用和有用的补充。具体地说，通过在微米和纳米尺度上控制生物相容聚合物的表面特征，以及通过系统地了解地形、孔隙率和化学如何影响生物组织的粘附性，将开发一类新的强粘附性微/纳米织构生物材料。通过使用柔软、灵活的材料，纹理表面应该很容易符合不规则形状的表面，如软组织，从而最大化界面上的分子相互作用。 与公共健康相关：这项建议的目的是通过工程基材的形貌和化学作用开发一种新型的组织胶带(即内绷带)，以满足当前医学对能够与组织牢固结合并促进伤口愈合过程的粘合剂的需求。这种新型生物医学材料的发展将对包括肠道、膀胱、肺、硬脑膜和肌肉在内的许多组织的伤口修复具有广泛的意义。潜在的好处包括减少手术时间，减少组织处理，以及通过消除缝合的需要来减少手术并发症，如感染。

DESCRIPTION (provided by applicant): There is a significant medical need for an adhesive that can bond strongly to soft tissues and incisions that facilitates healing and minimizes inflammation. These materials can potentially reduce operating time, tissue handling, and mitigate complications such as infection. While numerous tissue adhesives exist, their applications are restricted due to limitations such as insufficient mechanical properties, increased inflammation and difficulty in application to certain wound geometries. We have recently developed a textured tissue tape that is biocompatible with tunable mechanical, degradation and adhesive properties. Functional testing against tissue showed maximum adhesion strength of 0.8 N/cm2, but in order to translate these materials to medical applications, adhesion strengths of ~5-15 N/cm2 are required. In this proposal, we aim to develop an adhesive that bonds strongly and can be applied to a variety of tissues. We will reveal the fundamental scientific and engineering principles required to fabricate biologically interfacing adhesives with well-defined surface morphologies and chemistries without inducing a significant inflammatory response. Through enhancing the adhesion of our existing nanostructured tapes and through elucidating mechanisms that impact adhesion to different tissues, the proposed research will provide a potential platform for discovery of new science that leads to many practical and useful additions to the surgical armentarium. Specifically, a new class of strongly adhesive micro/nano textured biomaterials will be developed by controlling the surface features of biocompatible polymers on the micro and nanoscale, and by systematically developing an understanding of how topography, porosity, and chemistry influence adhesion to biological tissues. Through using soft, flexible materials, the textured surfaces should easily conform to irregularly shaped surfaces, such as soft tissue, thereby maximizing molecular interactions at the interface. PUBLIC HEALTH RELEVANCE: The aim of this proposal is to develop a novel tissue tape (i.e. an internal bandage) through engineered substrate topography and chemistry that can satisfy the current medical demand for an adhesive that can bond strongly to tissue and facilitate the wound healing process. The development of this novel biomedical material will have broad implications for wound repair of many tissues including gut, bladder, lung, dura, and muscle. Potential benefits include reduction in operating time, tissue handling, and mitigation of surgical complications such as infection by eliminating the need for sutures.