Biomedical adhesives with precisely engineered surface topography and chemistry

具有精确设计的表面形貌和化学性质的生物医学粘合剂

• 批准号: 8061961
• 负责人: Jeffrey Michael Karp
• 金额: $ 33.93万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061961
• 关键词: Acrylates; Adhesions; Adhesives; Affect; Air; Anastomosis - action; Animal Model; Animal Testing; Bandage; Binding; Biochemical; Biocompatible; Biocompatible Materials; Biological; Bladder; Chemicals; Chemistry; Covalent Interaction; Crohn' s disease; Development; Disease; Drug Delivery Systems; Dura Mater; Elastomers; Engineering; Ensure; Excision; Gastric Bypass; Healed; Hemostatic function; Histocompatibility Testing; Implant; In Vitro; Infection; Inflammation; Inflammatory Response; Laceration; Lung; Malignant neoplasm of lung; Mechanics; Medical; Microscopic; Modeling; Modification; Morphology; Motivation; Muscle; Obesity; Operative Surgical Procedures; Pattern; Performance; Pneumothorax; Polymers; Porosity; Procedures; Process; Property; Research; Science; Shapes; Surface; Surgical complication; Surgical incisions; Surgical sutures; Technology; Tensile Strength; Testing; Texture; Time; Tissue Adhesives; Tissues; Translating; Water; Work; Wound Healing; base; biocompatible polymer; biodegradable polymer; biomaterial compatibility; controlled release; crosslink; elastomeric; flexibility; healing; hydroxyl group; improved; in vivo; mouse model; nano; nanoscale; nanostructured; novel; poly(glycerol-sebacate); prevent; public health relevance; research study; response; scaffold; seal; soft tissue; subcutaneous; wound

DESCRIPTION (provided by applicant): There is a significant medical need for an adhesive that can bond strongly to soft tissues and incisions that facilitates healing and minimizes inflammation. These materials can potentially reduce operating time, tissue handling, and mitigate complications such as infection. While numerous tissue adhesives exist, their applications are restricted due to limitations such as insufficient mechanical properties, increased inflammation and difficulty in application to certain wound geometries. We have recently developed a textured tissue tape that is biocompatible with tunable mechanical, degradation and adhesive properties. Functional testing against tissue showed maximum adhesion strength of 0.8 N/cm2, but in order to translate these materials to medical applications, adhesion strengths of ~5-15 N/cm2 are required. In this proposal, we aim to develop an adhesive that bonds strongly and can be applied to a variety of tissues. We will reveal the fundamental scientific and engineering principles required to fabricate biologically interfacing adhesives with well-defined surface morphologies and chemistries without inducing a significant inflammatory response. Through enhancing the adhesion of our existing nanostructured tapes and through elucidating mechanisms that impact adhesion to different tissues, the proposed research will provide a potential platform for discovery of new science that leads to many practical and useful additions to the surgical armentarium. Specifically, a new class of strongly adhesive micro/nano textured biomaterials will be developed by controlling the surface features of biocompatible polymers on the micro and nanoscale, and by systematically developing an understanding of how topography, porosity, and chemistry influence adhesion to biological tissues. Through using soft, flexible materials, the textured surfaces should easily conform to irregularly shaped surfaces, such as soft tissue, thereby maximizing molecular interactions at the interface. PUBLIC HEALTH RELEVANCE: The aim of this proposal is to develop a novel tissue tape (i.e. an internal bandage) through engineered substrate topography and chemistry that can satisfy the current medical demand for an adhesive that can bond strongly to tissue and facilitate the wound healing process. The development of this novel biomedical material will have broad implications for wound repair of many tissues including gut, bladder, lung, dura, and muscle. Potential benefits include reduction in operating time, tissue handling, and mitigation of surgical complications such as infection by eliminating the need for sutures.

描述（由申请人提供）：医学上迫切需要一种粘合剂，它可以牢固地粘合到软组织和切口上，从而促进愈合并最大限度地减少炎症。这些材料可以潜在地减少手术时间、组织处理并减轻感染等并发症。虽然存在多种组织粘合剂，但由于机械性能不足、炎症增加以及难以应用于某些伤口几何形状等限制，它们的应用受到限制。我们最近开发了一种纹理纸巾胶带，具有生物相容性，具有可调节的机械、降解和粘合性能。针对组织的功能测试显示最大粘合强度为 0.8 N/cm2，但为了将这些材料转化为医疗应用，需要约 5-15 N/cm2 的粘合强度。 在该提案中，我们的目标是开发一种粘合力强且可应用于多种组织的粘合剂。我们将揭示制造具有明确表面形态和化学性质的生物界面粘合剂而不引起明显炎症反应所需的基本科学和工程原理。通过增强现有纳米结构胶带的粘附力并阐明影响不同组织粘附力的机制，拟议的研究将为发现新科学提供一个潜在平台，从而为外科手术带来许多实用和有用的补充。具体来说，将通过在微米和纳米尺度上控制生物相容性聚合物的表面特征，并系统地了解形貌、孔隙率和化学如何影响对生物组织的粘附性，来开发一类新型强粘附性微米/纳米纹理生物材料。通过使用柔软、灵活的材料，纹理表面应该很容易符合不规则形状的表面，例如软组织，从而最大化界面处的分子相互作用。 公共健康相关性：该提案的目的是通过工程基材形貌和化学来开发一种新型组织胶带（即内部绷带），以满足当前对能够牢固地粘合到组织并促进伤口愈合过程的粘合剂的医疗需求。这种新型生物医学材料的开发将对许多组织的伤口修复产生广泛的影响，包括肠道、膀胱、肺、硬脑膜和肌肉。潜在的好处包括减少手术时间、组织处理以及通过消除缝合的需要来减轻感染等手术并发症。