Data Mangement and Statistics

数据管理和生物统计核心的总体目标是1)整合和管理数据 来自不同的站点和多种类型(临床结果、实验室数据)，使研究人员能够访问 并利用来自全球各地站点的安全存储的数据，以及2)提供生物统计学专业知识 项目协查人员和私人投资经理执行更复杂的分析，并在实施中提供建议 在不太复杂的分析中，核心生物统计学家核心派(弗里德曼)将实现核心目标 (Potts)和核心数据管理器(Twark)。弗里德曼博士将负责监督这些数据 个别项目和调查人员的管理和生物统计需求。 该核心的主要目标之一是向所有项目和 调查人员。具体地说，数据管理员和Core PI将设计基于Web的数据录入平台 屏幕、随附的案例报告表，并确保本网站和数据的安全。核心将是 负责对所有地点的数据录入人员进行培训，并监督和排除数据录入故障 问题。数据管理员将负责清理和合并来自不同来源的数据 包括来自人类实地研究的协变量和实验室产生的基本科学数据。数据 经理和核心PL将负责向具有批准访问权限的调查人员提供合并文件 通过这个基于网络的平台。 核心的第二个目标是支持所有三个项目的数据分析活动，特别是 强调项目1和2的更复杂的数据分析需求。这些活动将由 核心Pl(Friedman)，由PI和生物统计学家共同执行。在某些情况下，例如购物车， 重复测量和ROC分析，核心将与项目协作执行分析 PL和合作调查员。对于其他分析，核心将向PIS项目和协查人员提供咨询 执行与其项目相关的分析。这包括在正确的 此外，它还为采用更具创新性的分析方法提供了机会。

The overall objectives of the Data Management and Biostatistics Core are to 1) integrate and manage data from disparate sites and of many types (clinical outcomes, laboratory data) allowing investigators to access and utilize securely stored data from sites located across the globe and 2) provide biostatistical expertise for project co-investigators and Pis in the execution of more complex analyses as well as advice in the conduct of less complex analyses, he goals of the Core will be met by the Core PI (Friedman), Core Biostatistician (Potts), and Core Data Manager (Twark). Dr Friedman will be charged with overseeing the data management and biostatistical needs of individual projects and investigators. One of the main goals of this Core is to provide data management expertise and service to all projects and investigators. Specifically, the data manager and Core PI, will design the web-based platform with data entry screens, accompanying case report forms, and ensure the security of this site and data. The Core will be responsible for educating data entry personnel at all sites and overseeing and troubleshooting data entry issues. The data manager will be responsible for cleaning and merging data from disparate sources including covariates from human field studies and basic scientific data generated in the laboratory. The data manager and Core Pl will take responsibility for providing merged files to investigators with approved access through this web-based platform. The second goal of the Core is to support data analytic activities for all three projects, with particular emphasis on the more complex data analytic needs of Projects 1 and 2. These activities will be led by the core Pl (Friedman) and executed by both the PI and biostatistician. In some cases, for example CART, repeated measures, and ROC analyses, the Core will execute the analyses in collaboration with the project Pl and co-investigators. For other analyses, the Core will provide consultation to Project Pis and coinvestigators in the execution of analyses relevant to their projects. This includes guidance in the correct approach as well as providing opportunities for more innovative approaches to the analyses.