Point-of-care Testing for Illicit Drugs and Alcohol Intoxication in an Emergency

紧急情况下非法药物和酒精中毒的现场检测

基本信息

批准号：
8453852
负责人：
Marcel Benz
金额：
$ 49.68万
依托单位：
SEACOAST SCIENCE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8453852
关键词：
Accident and Emergency department Address Affect Alcoholic Intoxication Alcohols Ankle Area Aviation Bedside Testings Blood Blood specimen Caring Cities Computer software Consumption Decision Making Detection Development Devices Diagnostic Diagnostic tests Drug Costs Drug Tolerance Emergency Care Emergency Situation Emergency treatment Engineering Environment Ethanol Face Forensic Medicine Gases Gel Goals Hand Harvest Head Start Program Health Health Sciences Hour Illicit Drugs Immunoassay Institutes Institution Intake Laboratories Law Enforcement Letters Libraries Marketing Measurement Medical Medical center Military Personnel Mission Modification Monitor Motor Names Narcotics Patients Pattern Performance Persons Pharmaceutical Preparations Phase Physicians Policies Polymers Preclinical Drug Evaluation Quartz Railroads Resolution Safety Sampling Science Security Semiconductors Skin Small Business Innovation Research Grant Source Spectrum Analysis Surface Swab System Technology Testing Time Urine Vision Wireless Technology Workplace alcohol monitoring arm base care seeking clinical decision-making cost detector drug of abuse illicit drug detection improved instrument interest ion mobility metal oxide minimally invasive next generation non-drug novel point of care point-of-care diagnostics pressure problem drinker programs prototype public health relevance research study sample collection screening sensor sound tool vapor

项目摘要

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I proposal focuses on the development of a small-sized, portable, point-of-contact analytical instrument; a screening tool for the simultaneous detection of alcohol and narcotics. The core technology is a miniature gas chromatograph (Mini-GC) that uses a multi-detector system to analyze the drug traces. Persons adversely affected by drugs of abuse comprise a substantial proportion of the patients that seek care in emergency departments. Seacoast's envisioned low-cost drug screener will provide physicians with an initial assessment of patients to facilitate the treatment decision making and enhance patient throughput. Most importantly, the screening test is non-invasive, does not require a blood or urine sample, but instead collects traces of narcotics and transdermal alcohol from a patient's skin. The sample swabs will be an enhanced version of what is currently used at airports to look for explosives traces. Seacoast's novel Mini GC is independent of bulky carrier gas tanks but has the needed sensitivity through a combination of a synergistic sensor set. Specifically, a polymer coated quartz crystal microbalance, a metal oxide semiconductor, and an electrochemical ethanol sensor from the gas chromatograph's detector module. The idea of monitoring transdermal alcohol by means of an ankle bracelet and the trace detection of narcotics by ion mobility spectroscopy have both been applied separately for years; however, the two concepts have never before been combined in one instrument and made available at low cost. Seacoast's next generation Mini-GC with the multi-detector system will close this gap. This Phase II program is supported by UCSD's Medical Center ER team, which will organize an emergency department field trial where Seacoast's diagnostic Mini-GC will be compared to state-of- the-art urine or blood based toxicological laboratory tests.

描述（由申请人提供）：这一小型企业创新研究阶段的提案着重于开发小型，便携式，接触点的分析工具；同时检测酒精和麻醉品的筛选工具。核心技术是一种微型气相色谱仪（Mini-GC），它使用多探测器系统来分析药物痕迹。受虐待药物的不利影响的人占急诊室寻求护理的大部分患者。 Seacoast的设想低成本药物筛选器将为医生提供对患者的初步评估，以促进治疗决策并增强患者吞吐量。最重要的是，筛查测试是无创的，不需要血液或尿液样本，而是从患者的皮肤中收集麻醉品和透皮酒精的痕迹。样品拭子将是当前在机场寻找炸药痕迹的增强版本。海岸的小说迷你 GC独立于笨重的载气罐，但通过协同传感器组合的组合具有所需的灵敏度。具体而言，来自气相色谱仪的检测器模块的聚合物涂层石英晶体微量平衡，金属氧化物半导体和电化学乙醇传感器。通过脚踝手镯监测透皮酒精的想法，以及通过离子迁移率光谱检查对麻醉剂的痕量检测既已分别应用了多年。但是，这两个概念从来没有被合并为一种乐器，并以低成本提供。 Seacoast的下一代迷你GC带有多探测器系统将缩小这一差距。该阶段II计划得到了UCSD的医疗中心ER团队的支持，该团队将组织一项急诊部现场试验，其中将将Seacoast的诊断迷你GC与ART-ART尿液或基于血液的毒理学实验室测试进行比较。