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Point-of-care Testing for Illicit Drugs and Alcohol Intoxication in an Emergency

紧急情况下非法药物和酒精中毒的现场检测

基本信息

批准号：
8655531
负责人：
Marcel Benz
金额：
$ 45.5万
依托单位：
SEACOAST SCIENCE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8655531
关键词：
Accident and Emergency department Address Affect Alcoholic Intoxication Alcohols Ankle Area Aviation Bedside Testings Blood Blood specimen Caring Cities Computer software Consumption Decision Making Detection Development Devices Diagnostic Diagnostic tests Drug Costs Drug Tolerance Emergency Care Emergency Situation Emergency treatment Engineering Environment Ethanol Face Forensic Medicine Gases Gel Goals Hand Harvest Head Start Program Health Health Sciences Hour Illicit Drugs Immunoassay Institutes Institution Intake Laboratories Law Enforcement Letters Libraries Marketing Measurement Medical Medical center Military Personnel Mission Modification Monitor Motor Names Narcotics Patients Pattern Performance Persons Pharmaceutical Preparations Phase Physicians Policies Polymers Preclinical Drug Evaluation Quartz Railroads Resolution Safety Sampling Science Security Semiconductors Skin Small Business Innovation Research Grant Source Spectrum Analysis Surface Swab System Technology Testing Time Urine Vision Wireless Technology Workplace alcohol monitoring arm base care seeking clinical decision-making cost detector drug of abuse illicit drug detection improved instrument interest ion mobility metal oxide minimally invasive next generation non-drug novel point of care point-of-care diagnostics pressure problem drinker programs prototype public health relevance research study sample collection screening sensor sound tool vapor

项目摘要

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I proposal focuses on the development of a small-sized, portable, point-of-contact analytical instrument; a screening tool for the simultaneous detection of alcohol and narcotics. The core technology is a miniature gas chromatograph (Mini-GC) that uses a multi-detector system to analyze the drug traces. Persons adversely affected by drugs of abuse comprise a substantial proportion of the patients that seek care in emergency departments. Seacoast's envisioned low-cost drug screener will provide physicians with an initial assessment of patients to facilitate the treatment decision making and enhance patient throughput. Most importantly, the screening test is non-invasive, does not require a blood or urine sample, but instead collects traces of narcotics and transdermal alcohol from a patient's skin. The sample swabs will be an enhanced version of what is currently used at airports to look for explosives traces. Seacoast's novel Mini GC is independent of bulky carrier gas tanks but has the needed sensitivity through a combination of a synergistic sensor set. Specifically, a polymer coated quartz crystal microbalance, a metal oxide semiconductor, and an electrochemical ethanol sensor from the gas chromatograph's detector module. The idea of monitoring transdermal alcohol by means of an ankle bracelet and the trace detection of narcotics by ion mobility spectroscopy have both been applied separately for years; however, the two concepts have never before been combined in one instrument and made available at low cost. Seacoast's next generation Mini-GC with the multi-detector system will close this gap. This Phase II program is supported by UCSD's Medical Center ER team, which will organize an emergency department field trial where Seacoast's diagnostic Mini-GC will be compared to state-of- the-art urine or blood based toxicological laboratory tests.

描述（由申请人提供）：此小企业创新研究第一阶段提案侧重于开发小型，便携式，接触式分析仪器；同时检测酒精和麻醉品的一种筛选工具。其核心技术是微型气相色谱仪（Mini-GC），使用多检测器系统分析药物痕迹。在急诊科寻求治疗的病人中，受滥用药物不良影响的人占很大比例。seacast设想的低成本药物筛选器将为医生提供对患者的初步评估，以促进治疗