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Functional Analysis of Sleep Promoting Neurons in Health and Disease

睡眠促进神经元在健康和疾病中的功能分析

基本信息

批准号：
8517844
负责人：
PAUL J SHAW
金额：
$ 28.23万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8517844
关键词：
Adult Adverse effects Aging Alzheimer&apos s Disease Animal Model Animals Attenuated Behavior Biological Brain Calcium Camping Cells Chronic Circadian Rhythms Cognitive Cognitive deficits Cyclic AMP Data Degenerative Disorder Disease Dorsal Drosophila genus Exposure to Frequencies Gene Mutation Genetic Health Image Impaired cognition Invertebrates Life Link Longevity Measures Modeling Molecular Morbidity - disease rate Neurodegenerative Disorders Neurons Neuropeptides Parkinson Disease Pathology Pathway interactions Patients Pattern Pharmaceutical Preparations Play Presynaptic Terminals Process Property Proteins Role Shapes Signal Transduction Sleep Sleep Deprivation Sleep Disorders Social Environment Starvation Testing Therapeutic Time Vulnerable Populations cellular imaging fly human disease improved in vivo meetings mortality mutant presenilin research study response sensor tool

项目摘要

DESCRIPTION (provided by applicant): We have identified a group of ~20 neurons that can be activated on-demand using Drosophila genetics. The sleep observed during activation of these neurons meets the historical definition for identifying sleep. Our data highlight the importance of these neurons for regulating sleep. In this proposal we will use live-cell imaging and in vivo electrophysiological recording from Drosophila brains to define the properties of these neurons in the intact brain. The ability to use Drosophila genetics to induce sleep provides a unique opportunity to examine whether sleep can be used as a therapeutic for slowing or attenuating cognitive impairments associated with degenerative diseases. Thus, we will determine whether inducing sleep in Drosophila models of Parkinson's and Alzheimer's disease can offset deficits in cognitive behavior.

描述（由申请人提供）：我们已经确定了一组约 20 个神经元，可以使用果蝇遗传学按需激活。这些神经元激活期间观察到的睡眠符合识别睡眠的历史定义。我们的数据强调了这些神经元对于调节睡眠的重要性。在本提案中，我们将使用果蝇大脑的活细胞成像和体内电生理记录来定义完整大脑中这些神经元的特性。利用果蝇遗传学诱导睡眠的能力提供了一个独特的机会来检查睡眠是否可以用作减缓或减轻与退行性疾病相关的认知障碍的治疗方法。因此，我们将确定在帕金森病和阿尔茨海默病的果蝇模型中诱导睡眠是否可以抵消认知行为的缺陷。