Functional Analysis of Sleep Promoting Neurons in Health and Disease

睡眠促进神经元在健康和疾病中的功能分析

• 批准号: 9921498
• 负责人: PAUL J SHAW
• 金额: $ 32.8万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9921498
• 关键词: ATP Receptors; Air; Alzheimer' s Disease; Alzheimer' s disease model; Animals; Architecture; Arousal; Attention; Awareness; Behavior; Behavioral; Brain; Brain imaging; Calcium; Cells; Characteristics; Cognition; Cognitive; Complex; Cyclic AMP; Data; Dependence; Disease; Dorsal; Drosophila genus; Equilibrium; Goals; Health; Human; Human Amyloid Precursor Protein; Impaired cognition; Individual; Learning; Light; Link; Memory; Mind; Monitor; Neurologic; Neurons; Peptides; Phenotype; Physiological; Physiology; Population; Process; Property; Proteins; Risk; Role; S-nitro-N-acetylpenicillamine; Signal Transduction; Sleep; Sleep Deprivation; Structure; Synapses; System; Testing; Time; Walking; Work; base; beta secretase; beta-site APP cleaving enzyme 1; cognitive function; cognitive process; connectome; experimental study; fly; interest; memory consolidation; nervous system disorder; neural circuit; optogenetics; relating to nervous system; response; selective attention; sensor; tau Proteins; tool; vesicle-associated membrane protein; virtual reality

Sleep, selective-attention and memory consolidation are adversely impacted by many, if not most, neurological conditions. Interestingly, recent studies suggest that neuronal activity during waking may alter the risk for developing Alzheimer's disease. With this in mind, we have identified a genetically-tractable neural circuit that is impacted by Alzheimer's disease and is also uniquely suited for dissecting the dynamic, bi-directional relationship between sleep and cognition. That is, we are less interested in defining a minimal set of neurons that control a behavior than we are in understanding how these neurons interact (e.g., via a sleep- cognitive connectome). In this proposal we will investigate how connected structures in the fly brain work together to regulate sleep and cognition during health and in the context of Alzheimer's disease. Since we have recently demonstrated that the power of sleep can be harnessed to reverse cognitive impairments in a Drosophila model of Alzheimer's disease, a goal of this proposal will be to define the functional properties of circuits that confer the benefits of sleep to cognitive processes.

睡眠，选择性注意力和记忆巩固受到许多不利影响，如果没有 大多数是神经系统疾病有趣的是，最近的研究表明神经元活动 可能会改变患老年痴呆症的风险。有鉴于此，我们 已经发现了一种受阿尔茨海默病影响的遗传易处理的神经回路 也是唯一适合于剖析动态，双向关系， 睡眠和认知也就是说，我们对定义一组最小的神经元不太感兴趣， 控制行为比我们在理解这些神经元如何相互作用（例如，通过睡眠- 认知连接体）。在这个建议中，我们将研究如何连接结构在苍蝇 在健康期间，大脑共同调节睡眠和认知， 老年痴呆症因为我们最近证明了睡眠的力量可以 利用它来逆转阿尔茨海默病果蝇模型中的认知障碍， 该提案的目标是定义电路的功能特性， 睡眠对认知过程的好处

项目成果

Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila.

• DOI: 10.7554/elife.88198
• 发表时间: 2023-11-01
• 期刊: eLife
• 影响因子: 7.7
• 作者: Anthoney N;Tainton-Heap L;Luong H;Notaras E;Kewin AB;Zhao Q;Perry T;Batterham P;Shaw PJ;van Swinderen B
• 通讯作者: van Swinderen B

A dynamic deep sleep stage in Drosophila.

• DOI: 10.1523/jneurosci.0061-13.2013
• 发表时间: 2013-04-17
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: van Alphen B;Yap MH;Kirszenblat L;Kottler B;van Swinderen B
• 通讯作者: van Swinderen B

Neural Ensemble Fragmentation in the Anesthetized Drosophila Brain.

麻醉果蝇大脑中的神经整体碎片。

• DOI: 10.1523/jneurosci.1657-22.2023
• 发表时间: 2023
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Troup,Michael;Tainton-Heap,LucyAL;vanSwinderen,Bruno
• 通讯作者: vanSwinderen,Bruno

Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation.

• DOI: 10.1152/jn.00414.2013
• 发表时间: 2013-10
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: A. Paulk;Yanqiong Zhou;Peter G. Stratton;Li Liu;B. van Swinderen

Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness.

• DOI: 10.7554/elife.37105
• 发表时间: 2018-08-15
• 期刊: eLife
• 影响因子: 7.7
• 作者: Troup M;Yap MH;Rohrscheib C;Grabowska MJ;Ertekin D;Randeniya R;Kottler B;Larkin A;Munro K;Shaw PJ;van Swinderen B
• 通讯作者: van Swinderen B