2020 Sleep Regulation and Function GRC/GRS

2020睡眠调节与功能GRC/GRS

• 批准号: 9913644
• 负责人: PAUL J SHAW
• 金额: $ 3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913644
• 关键词: Aging; Alzheimer' s Disease; Americas; Animals; Asia; Awareness; Behavior; Brain; Brain region; Caenorhabditis elegans; Cardiovascular system; Chronic; Clinical; Committee Members; Communities; Complement; Degenerative Disorder; Development; Dopamine; Drosophila genus; Electrophysiology (science); Emotions; Europe; Event; Fostering; Funding; Future; Genes; Genetic; Genetic study; Goals; Human; Imaging Techniques; Individual; Learning; Light; Link; Longevity; Memory; Mental disorders; Metabolic; Methods; Modeling; Molecular Genetics; Monitor; Mus; Neurons; Neurosciences; Oral; Participant; Performance; Play; Postdoctoral Fellow; Property; REM Sleep; Regulation; Research; Research Personnel; Role; Scientist; Signal Transduction; Site; Sleep; Sleep Stages; Sleep Wake Cycle; Sleep disturbances; Synapses; System; Technology; Time; Training; Travel; Uncertainty; Woman; Work; biological systems; career; cost; fly; genetic approach; graduate student; imaging study; insight; meetings; neuronal circuitry; neurovascular; next generation; novel; optogenetics; posters; programs; sleep quality; sleep quantity; sleep regulation; sleep spindle; success; symposium; transcriptomics

Project Summary The 2020 (Systems Neuroscience and Genetic Approaches to Study Sleep Regulation and Function) will be the fourth Sleep GRC. In this meeting we will cover topics that have not been included in past meetings. Past meetings have discussed how modulating sleep regulatory neurons using optogenetics or chemogenetics impacts sleep time. However, there is a growing awareness that seemingly homogenous neurons are, in fact, much more heterogeneous than previously believed. Identifying and gaining genetic access to neurons with unique properties so that they can be manipulated and monitored will be essential for fully understanding sleep regulation and function. Thus this meeting will begin by discussing new strategies for defining neuronal identity in diverse brain regions important for sleep. Identifying additional sleep regulatory components injects an added layer of complexity that makes it difficult to fully understand sleep regulation. As such, theoretical approaches for modeling how these new sleep-regulatory components might interact will be discussed. Importantly, the ability to identify and monitor specific neuronal subtypes is relevant to the future success of many topics presented throughout the meeting. Chief amongst these is a session devoted to understanding how metabolic factors impact the sleep-wake cycle; a long standing goal of sleep research. Although past meeting have included discussion on how sleep-specific electrophysiological signals (e.g. sleep spindles) modulate discrete brain regions, this meeting will examine how sleep impacts global brain dynamics in c elegans, Drosophila and mice and try and identify common, and evolutionarily conserved, regulatory principles. Given that sleep is a global phenomenon that impacts the entire brain, the 2020 Sleep GRC will extend the conversation of sleep function beyond synapses and memory. One session will discuss the impact of sleep during development on brain functioning and an additional session will examine the role of sleep in regulating of positive and negative emotions. Importantly these sessions will include the most recent studies using molecular-genetic approaches for identify underlying circuitry and genes in animals as well as genetic and imaging studies in humans. A past meeting has covered the relationship between sleep and Alzheimer’s disease but new advances in the field using human transcriptomics and imaging techniques are shedding new light on this topic and will be discussed in 2020. Finally, since genes alter behavior by impacting specific neuronal circuits, we will conclude the meeting by discussing recent developments in identifying new genes that modulate sleep in mice and humans.

项目摘要 2020年（系统神经科学和遗传方法研究睡眠调节和功能） 第四集Sleep GRC在这次会议中，我们将讨论过去会议中没有包括的主题。过去 会议讨论了如何使用光遗传学或化学遗传学调节睡眠调节神经元 影响睡眠时间。然而，人们越来越意识到，看似同质的神经元实际上是， 比以前认为的更加异质。识别并获得神经元的遗传途径 这些独特的特性使得它们可以被操纵和监测，这对于充分理解睡眠是必不可少的。 规则和功能。因此，本次会议将开始讨论新的战略，确定神经元的身份 在不同的大脑区域对睡眠很重要。识别额外的睡眠调节成分， 这增加了一层复杂性，使人们很难完全理解睡眠调节。因此，理论上 将讨论模拟这些新的睡眠调节成分如何相互作用的方法。 重要的是，识别和监测特定神经元亚型的能力与未来的成功相关。 在整个会议期间提出了许多问题。其中最主要的是一个会议， 代谢因素如何影响睡眠-觉醒周期;睡眠研究的长期目标。尽管过去的 会议讨论了睡眠特异性电生理信号（如睡眠纺锤波） 调节离散的大脑区域，本次会议将研究睡眠如何影响c 线虫、果蝇和小鼠，并试图找出共同的、进化上保守的调控原则。 鉴于睡眠是一种影响整个大脑的全球现象，2020年睡眠GRC将延长睡眠时间。 超越突触和记忆的睡眠功能的对话。其中一节课将讨论睡眠的影响 在大脑功能的发展过程中，额外的会议将研究睡眠在调节大脑功能中的作用。 积极和消极的情绪。重要的是，这些会议将包括最新的研究， 分子遗传学方法，用于识别动物中的潜在电路和基因，以及遗传和 人体成像研究。过去的一次会议讨论了睡眠和老年痴呆症之间的关系 疾病，但在该领域的新进展，使用人类转录组学和成像技术正在脱落新的 关于这个问题，我们将在2020年讨论。最后，由于基因通过影响特定的 神经元回路，我们将通过讨论识别新基因的最新进展来结束会议 调节小鼠和人类睡眠的基因。