Synapse Neurobiology Training Program

突触神经生物学培训计划

• 批准号: 8704483
• 负责人: Michele H. Jacob
• 金额: $ 2.9万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8704483
• 关键词: Neurobiology; Synapses; Training Programs

See instructions): Multidisciplinary approaches drive progress in the neurosciences perhaps more than in most other areas of biomedical research. The next generation of research neuroscientists, therefore, must be equipped with a multi-faceted skill set if they are to transition to successful independent careers and contribute meaningfully to the field. To meet this challenge, we propose a new predoctoral Synapse Neurobiology Training Program (SNTP) at Tufts University School of Medicine that will provide in-depth, multidisciplinary research education of 4 trainees in the area of synaptic function-a particular strength of the Tufts neuroscience faculty. The synapse forms the foundation of nervous system function, and research on synapses is, arguably, one of the most interdisciplinary areas in modern neurobiology. The SNTP training plan, thus, includes several mechanisms that position trainees to become leading neuroscientists, working at the interface between traditional disciplines: ¿ Each trainee will be co-mentored by two SNTP faculty members who provide training in distinct yet complementary areas. ¿ Through subsidized, one-on-one training in imaging, bioinformatics, electrophysiology, and animal behavior methods (provided via the core facilities and PhD-level Managers in the NINDS-funded Center for Neuroscience Research at Tufts), SNTP trainees will acquire the state-of-the-art tools and training required for an effective and influential multidisciplinary approach. ¿ Innovative quantitative skills and techniques courses and individualized training plans will further aid each SNTP trainee in mastering the necessary skills to accomplish his/her research career goals. ¿ Frequent opportunities for individual interactions with visiting speakers will provide SNTP trainees with further exposure to new methodologies and ideas as well as advice and guidance. RELEVANCE (See instructions): Myriad disorders of the nervous system-e.g., epilepsy, ataxia, Parkinson's Disease, dementia, and stroke- involve fundamental alterations in synaptic function; dozens of mutations and polymorphisms in pre and postsynaptic receptors and ion channels are implicated in human neurological diseases. The development of future therapeutic approaches for such diseases will increasingly rely on advances made by a continuing cadre of investigators trained to unravel the fundamental mechanisms underlying synapse function. The goal of the SNTP is, thus, to ensure that our trainees have the tools and training required to shape the future of neuroscience through enhanced understanding of synaptic function in health and disease.

请参阅说明)： 多学科方法推动了神经科学的进步，也许比大多数其他领域的 生物医学研究。因此，下一代研究神经科学家必须具备 如果他们想要过渡到成功的独立职业生涯并做出有意义的贡献，就需要多方面的技能 到战场上去。为了迎接这一挑战，我们提出了一个新的博士前Synapse神经生物学培训计划 塔夫茨大学医学院(SNTP)将提供深入的、多学科的研究教育 在突触功能领域的4名受训人员--这是塔夫茨神经科学学院的一个特别强项。这个 突触构成神经系统功能的基础，而对突触的研究可以说是 现代神经生物学中的大多数跨学科领域。因此，SNTP培训计划包括几个 将受训人员定位为领先的神经科学家的机制，在 传统学科： ？每个受训人员将由两名SNTP教员共同指导，他们提供独特而又 相互补充的领域。 ？通过在成像、生物信息学、电生理学和动物方面提供补贴的一对一培训 行为方法(通过NINDS资助的核心设施和博士级别的管理人员提供 塔夫茨神经科学研究中心)，SNTP学员将获得最先进的工具和 有效和有影响力的多学科方法所需的培训。 创新的量化技能和技术课程和个性化的培训计划将进一步帮助 每个SNTP受训人员都需要掌握必要的技能，以实现其研究职业目标。 ？与来访演讲者进行个人互动的频繁机会将为SNTP学员提供 进一步接触新的方法和想法以及咨询和指导。 相关性(请参阅说明)： 神经系统的各种疾病--例如癫痫、共济失调、帕金森氏症、痴呆症和中风-- 涉及突触功能的根本改变；Pre和Pre 突触后受体和离子通道与人类神经系统疾病有关。的发展。 未来此类疾病的治疗方法将越来越依赖于持续不断的 一批研究人员接受了解开突触功能的基本机制的培训。目标是 因此，SNTP的目的是确保我们的受训人员拥有塑造未来所需的工具和培训 通过加强对健康和疾病中突触功能的了解，促进神经科学的发展。