Synapse Neurobiology Training Program

突触神经生物学培训计划

• 批准号: 8263419
• 负责人: Michele H. Jacob
• 金额: $ 16.19万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8263419
• 关键词: Neurobiology; Synapses; Training Programs

See instructions): Multidisciplinary approaches drive progress in the neurosciences perhaps more than in most other areas of biomedical research. The next generation of research neuroscientists, therefore, must be equipped with a multi-faceted skill set if they are to transition to successful independent careers and contribute meaningfully to the field. To meet this challenge, we propose a new predoctoral Synapse Neurobiology Training Program (SNTP) at Tufts University School of Medicine that will provide in-depth, multidisciplinary research education of 4 trainees in the area of synaptic function-a particular strength of the Tufts neuroscience faculty. The synapse forms the foundation of nervous system function, and research on synapses is, arguably, one of the most interdisciplinary areas in modern neurobiology. The SNTP training plan, thus, includes several mechanisms that position trainees to become leading neuroscientists, working at the interface between traditional disciplines: ¿ Each trainee will be co-mentored by two SNTP faculty members who provide training in distinct yet complementary areas. ¿ Through subsidized, one-on-one training in imaging, bioinformatics, electrophysiology, and animal behavior methods (provided via the core facilities and PhD-level Managers in the NINDS-funded Center for Neuroscience Research at Tufts), SNTP trainees will acquire the state-of-the-art tools and training required for an effective and influential multidisciplinary approach. ¿ Innovative quantitative skills and techniques courses and individualized training plans will further aid each SNTP trainee in mastering the necessary skills to accomplish his/her research career goals. ¿ Frequent opportunities for individual interactions with visiting speakers will provide SNTP trainees with further exposure to new methodologies and ideas as well as advice and guidance. RELEVANCE (See instructions): Myriad disorders of the nervous system-e.g., epilepsy, ataxia, Parkinson's Disease, dementia, and stroke- involve fundamental alterations in synaptic function; dozens of mutations and polymorphisms in pre and postsynaptic receptors and ion channels are implicated in human neurological diseases. The development of future therapeutic approaches for such diseases will increasingly rely on advances made by a continuing cadre of investigators trained to unravel the fundamental mechanisms underlying synapse function. The goal of the SNTP is, thus, to ensure that our trainees have the tools and training required to shape the future of neuroscience through enhanced understanding of synaptic function in health and disease.

参见说明）： 多学科方法推动神经科学的进步可能比大多数其他领域更重要。 生物医学研究因此，下一代神经科学家必须具备一个 多方面的技能，如果他们要过渡到成功的独立职业生涯，并作出有意义的贡献 到现场。为了迎接这一挑战，我们提出了一个新的博士前突触神经生物学培训计划 （SNTP）在塔夫茨大学医学院，将提供深入的，多学科的研究教育 在突触功能领域，塔夫茨大学神经科学系的一个特殊优势。的 突触是神经系统功能的基础，对突触的研究可以说是神经系统功能的基础之一。 现代神经生物学中最具交叉性的领域。因此，SNTP培训计划包括以下几个方面： 使受训者成为领先的神经科学家的机制， 传统学科： 每个学员将由两名SNTP教员共同指导，他们提供不同的培训， 互补领域。 通过在成像，生物信息学，电生理学和动物方面的补贴，一对一的培训， 行为方法（通过NINDS资助的核心设施和博士级管理人员提供） 在塔夫茨神经科学研究中心），SNTP学员将获得最先进的工具， 有效和有影响力的多学科方法所需的培训。 创新的量化技能和技术课程以及个性化的培训计划将进一步帮助 每个SNTP学员掌握必要的技能，以实现他/她的研究职业目标。 <$与来访演讲者进行个人互动的频繁机会将为SNTP学员提供 进一步接触新的方法和想法以及咨询和指导。 相关性（参见说明）： 无数的神经系统疾病-例如，癫痫、共济失调、帕金森病、痴呆和中风- 涉及突触功能的根本改变;前和后突触中的数十种突变和多态性， 突触后受体和离子通道与人类神经疾病有关。的发展 这些疾病的未来治疗方法将越来越多地依赖于持续的 一批受过训练的研究人员，他们的任务是解开突触功能的基本机制。目标 因此，SNTP的目的是确保我们的学员拥有塑造未来所需的工具和培训。 神经科学通过增强对健康和疾病中突触功能的理解。