Research Project Core

研究项目核心

• 批准号: 8496140
• 负责人: ROBERT H LA MOTTE
• 金额: $ 30.56万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496140
• 关键词: Awareness; Chemicals; Collection; Communication; Computer software; Core Facility; Data; Data Analyses; Data Collection; Databases; Development; Devices; Electronic Mail; Evaluation; Experimental Designs; Filament; General Population; Goals; Heating; Informatics; Institution; Laboratories; Methodology; Methods; Modeling; Molecular; Pain Research; Participant; Principal Investigator; Psychophysics; Public Health; Research Personnel; Research Project Grants; Resources; Schedule; Secure; Skin; Stimulus; Suggestion; Teleconferences; Temperature; data acquisition; design; instrument; instrumentation; medical schools; meetings; member; neuromechanism; neurophysiology; programs; repository; research study; skills; statistics; web site; web-enabled

Our program project proposes a combined psychophysical and neurophysiological study of the neural mechanisms of itch. The proposal requires the integrative efforts of three different laboratories each with different skills and experimental approaches. A core facility is proposed that will provide instrumentation, statistics, informatics and administration to each project. These four divisions of the core are designed to facilitate the planning of experiments as well as the collection, analysis, sharing, interpretation and evaluation of the data obtained. The instrumentation portion of core will assemble and maintain the instruments, hardware and software that will allow each project to deliver the same experimental stimuli and to use similar methods for experimental control, data acquisition and data analyses. The statistics portion of the core will provide assistance in formulating proper experimental designs, modeling and statistically analyzing results in each project and in making direct comparisons of results from one project with those of another: The informatics portion of the core will manage and develop a secure website that will allow members of each project to send data to a central repository at Yale that is accessible to each participant individually or for combined viewing by a group of participants through teleconferences over the intemet. The administration portion of the core will organize and schedule meetings with project leaders to discuss goals, data collection and interpretation, progress and problems at each of the three institutions in the form of ¿ regular teleconferences over the intemet between project participants, sometimes including institutional internal advisors, and in the form of face-to-face meetings each year with extemal advisors. The advisors will pnDvide evaluations and suggestions to help the projects achieve their objectives. Thus, the core is central resource for the use of common methodologies and statistical analyses and will provide an effective means of sharing, evaluating and integrating the psychophysical and neurophysiological information required to further our understanding of the neural mechanisms of itch.

我们的项目提出了对神经系统进行心理物理学和神经生理学的综合研究 瘙痒机制。该提案需要三个不同实验室的综合努力，每个实验室都有 不同的技能和实验方法。建议建立一个核心设施，提供仪器、 每个项目的统计、信息学和管理。核心的这四个部分旨在 促进实验的规划以及收集、分析、共享、解释和 对所获得的数据进行评估。核心的仪器部分将组装和维护 允许每个项目提供相同实验刺激的仪器、硬件和软件 使用类似的方法进行实验控制、数据采集和数据分析。统计部分 该核心将为制定适当的实验设计、建模和统计提供帮助 分析每个项目的结果，并将一个项目的结果与其他项目的结果进行直接比较 另一个：核心的信息学部分将管理和开发一个安全的网站，该网站将允许 每个项目的成员将数据发送到耶鲁大学的中央存储库，每个参与者都可以访问该存储库 单独或由一组参与者通过互联网电话会议联合观看。这 核心管理部分将组织和安排与项目负责人的会议，讨论目标， 以 ¿ 的形式介绍三个机构各自的数据收集和解释、进展和问题 项目参与者之间通过互联网定期举行电话会议，有时包括机构参与者 内部顾问，并每年以与外部顾问面对面会议的形式。顾问们 将提供评估和建议，以帮助项目实现其目标。于是，核心就是 使用共同方法和统计分析的中央资源，并将提供有效的 共享、评估和整合所需心理物理和神经生理学信息的方法 进一步了解瘙痒的神经机制。