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Prenatal tobacco exposure: effects on neuropsychological outcomes and ADHD

产前烟草暴露：对神经心理学结果和多动症的影响

基本信息

批准号：
8445338
负责人：
Valerie S Knopik
金额：
$ 18.52万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-30 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8445338
关键词：
Accounting Affect Age Alcohol or Other Drugs use Attention Attention deficit hyperactivity disorder Basic Science Behavior Birth Records Blood specimen Brain region Characteristics Child Childhood Cognition Cognitive Cognitive deficits Complement Conduct Disorder Confidential Information DNA Databases Diagnostic Enrollment Environmental Tobacco Smoke Event Exposure to Failure Family Fathers Funding Future Genetic Goals Health Health Personnel Impaired cognition Incentives Infant Interview Language Learning Life Literature Low Birth Weight Infant Masks Measures Memory Missouri Molecular Genetics Mothers Neurocognitive Newborn Infant Outcome Parents Perinatal Pregnancy Pregnant Women Probability Psychopathology Public Health Reading Reporting Research Research Personnel Risk Risk Factors Sampling Scheme School-Age Population Shipping Ships Siblings Smoke Smoking Symptoms TNFRSF5 gene Testing Text Time Tobacco Dependence Woman Work adolescent drug use adolescent substance use aged base clinically significant cohort design early life exposure executive function externalizing behavior fetal tobacco exposure genetic analysis interest maternal cigarette smoking neuropsychological offspring postnatal prenatal prenatal exposure transmission process

项目摘要

ABSTRACT-KNOPIK This re-revised new investigator R01 seeks funding to investigate the effects of prenatal tobacco exposure on offspring attention problems and associated learning and cognitive deficits. Maternal smoking during pregnancy (MSDP) is a major health concern associated with higher rates of a variety of poor child outcomes, including attention deficit hyperactivity disorder (ADHD), conduct disorder, impaired learning and memory, lowered IQ, and cognitive dysfunction. ADHD and many of these childhood outcomes are clinically significant conditions with clear public health implications and also are, in turn, substantial predictors of adolescent drug use problems. However, the evidence suggesting causal effects of MSDP for these childhood outcomes is muddied in the existing literature due to the frequent inability to separate these prenatal tobacco exposure effects from other confounding environmental and genetic factors. Specifically, the vast majority of prior studies provide only limited control for the fact that prenatal exposures may be correlated with parental behaviors that could also act as important risk factors that are in turn transmitted to their offspring. Failure to control for such (possibly heritable) confounding factors may account for a large part of the suggested associations between MSDP and offspring outcomes, resulting in biased effect sizes. Therefore, this application proposes to collect interview and comprehensive neuropsychological lab-based data from 400 families with at least 2 Missouri-born children (aged 8-15 at the time of testing), where the mother smoked during one pregnancy but not during a another pregnancy by the same father (thus, with offspring who are full sibling pairs discordant for prenatal tobacco exposure). This within-mother, between-pregnancy contrast provides the best possible methodologic control for confounding factors, such as heritable and sociodemographic characteristics of the mother that predict increased probability of MSDP, as well as other differences between mothers who do and do not smoke during pregnancy (and their partners). Such confounding factors, if not controlled for, might otherwise artifactually create, or alternatively mask, an association between MSDP and child outcomes (of particular interest for this proposal: memory, executive function, language/reading, and ADHD). Such a design will therefore provide opportunities to accurately determine effect sizes while also allowing us to develop a cohort which, in the future, could be followed longitudinally through periods of increased externalizing symptoms and substance use initiation.

ABSTRACT-KNOPIK

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence.

DOI：
10.1007/s00213-014-3748-2
发表时间：
2015-04
期刊：
PSYCHOPHARMACOLOGY
影响因子：
3.4
作者：
Bidwell, L. C.;McGeary, J. E.;Gray, J. C.;Palmer, R. H. C.;Knopik, V. S.;MacKillop, J.
通讯作者：
MacKillop, J.

Grand challenge in behavioral and psychiatric genetics: quantitative challenges to keeping up with molecular advances.

行为和精神遗传学的巨大挑战：跟上分子进步的定量挑战。

DOI：
10.3389/fgene.2011.00009
发表时间：
2011
期刊：
Frontiers in genetics
影响因子：
3.7
作者：
Knopik,ValerieS
通讯作者：
Knopik,ValerieS

Novelty Seeking as a Phenotypic Marker of Adolescent Substance Use.

DOI：
10.4137/sart.s22440
发表时间：
2015
期刊：
Substance abuse : research and treatment
影响因子：
0
作者：
Bidwell LC;Knopik VS;Audrain-McGovern J;Glynn TR;Spillane NS;Ray LA;Riggs NR;Guillot CR;Pang RD;Leventhal AM
通讯作者：
Leventhal AM

Prenatal substance exposure and offspring development: Does DNA methylation play a role?

产前物质暴露和后代发育：DNA 甲基化是否发挥作用？