REUSE IN RI: A STATE-BASED APPROACH TO COMPLEX EXPOSURES

RI 中的再利用：针对复杂暴露的基于国家的方法

• 批准号: 8249985
• 负责人: KIM BOEKELHEIDE
• 金额: $ 286.66万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-18 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8249985
• 关键词: Address; Applied Research; Area; Basic Science; Biological Markers; Biometry; Chemistry; Communication; Communities; Community Outreach; Complex; Complex Mixtures; Disease; Educational Intervention; Educational process of instructing; Engineering; Environmental Health; Evaluation; Goals; Government; Hazardous Waste Sites; Health; Health Hazards; Health Technology; Knowledge; Leadership; Metals; Modeling; Molecular Epidemiology; Nanotechnology; Outreach Research; Recording of previous events; Reproduction; Research; Research Infrastructure; Research Training; Resources; Rhode Island; Risk; Services; Site; Superfund; Techniques; Training; Training Programs; Translational Research; Universities; Work; base; design; member; molecular pathology; novel; programs; remediation; toxicant; vapor

This Superfund Basic Research and Training Program-Reuse in RI: A State-Based Approach to Complex Exposures-tackles through research and outreach three inter-related thematic challenges: 1) land reuse, 2) a state-based approach, and 3) complex exposures. Rhode Island is small, densely populated, and burdened by a long history of industrial activity. There are few barriers to academics, government leaders, and community members working together to address basic and translational research issues, management decisions, and communication complexities inherent to re-using hazardous waste sites. The research clusters 5 Biomedical and 3 Engineering Projects into Interdisciplinary Focus Areas: Nanotechnology & Metals, Molecular Epidemiology & Reproduction, and Semi-Volatile Organics & Vapor Intrusion, that investigate toxicant-induced disease mechanisms and develop potential biomarkers associated with co-exposures, and identify, characterize, separate, and remediate complex mixtures. These projects are supported by an Analytical Core-Chemistry and Biostatistics, a Molecular Pathology Core, and a Training Core. The Research Translation and Community Outreach Cores facilitate the flow of knowledge and information among the participating academics, government leaders, and community members in a true university-state-community partnership. The Administrative Core provides the infrastructure to promote communication, critical self-evaluation, and resource management. This program provides Rhode Islanders with a responsive center of technical excellence that takes a research-oriented approach to resolving the complex scientific, engineering, and societal issues that arise when considering the reuse of hazardous waste sites, by focusing on the following specific objectives: ¿ Provide Leadership - achieve excellence in basic and applied research, teaching, and service in environmental health and technology. ¿ Catalyze Research - increase understanding of health risks and solve technological challenges associated with remediation. ¿ Enhance Connectivity - build bridges across fields and create new interdisciplinary training and educational opportunities. ¿ Research Translation and Community Outreach - communicate health hazards, guide plans for reuse of contaminated sites, and increase the capacity of state agencies and community groups.

这个超级基金基础研究和培训计划-RI中的再利用：复杂暴露的基于状态的方法-通过研究和推广解决三个相互关联的主题挑战：1）土地再利用，2）基于状态的方法，以及3）复杂暴露。罗得岛面积小，人口稠密，工业活动历史悠久。学术界、政府领导人和社区成员共同努力解决基础和转化研究问题、管理决策和再利用危险废物场地所固有的沟通复杂性，几乎没有什么障碍。 该研究将5个生物医学项目和3个工程项目集中在跨学科重点领域：纳米技术与金属，分子流行病学与生殖，半挥发性有机物与蒸汽侵入，研究毒物诱导的疾病机制，开发与共同暴露相关的潜在生物标志物，并识别，表征，分离和修复复杂的混合物。这些项目由分析核心化学和生物统计学，分子病理学核心和培训核心支持。研究翻译和社区外展核心促进知识和信息在参与学者，政府领导人和社区成员之间的流动，形成真正的大学-国家-社区伙伴关系。行政核心提供基础设施，以促进沟通，关键的自我评价和资源管理。 该计划为罗得岛州居民提供了一个技术卓越的响应中心，该中心采用以研究为导向的方法来解决在考虑危险废物场地再利用时出现的复杂的科学，工程和社会问题，重点关注以下具体目标： 提供领导-在基础和应用研究，教学和环境卫生和技术服务方面取得卓越成就。 催化研究-增加对健康风险的了解，解决与补救相关的技术挑战。 增强连通性-建立跨领域的桥梁，创造新的跨学科培训和教育机会。 研究翻译和社区推广-宣传健康危害，指导污染场地的再利用计划，并提高国家机构和社区团体的能力。