Formative Center for the Evaluation of Environmental Impacts on Fetal Development

描述（由申请人提供）：行政核心的主要目标是促进、组织和促进形成中心的跨学科研究和核心活动。项目主管/首席研究员将提供领导、监督和组织控制，以最好地利用团队的才能和技能实现四个项目目标：1)在基础和临床研究中提供领导和创新，进一步加深我们对环境压力源及其对胎儿发育的影响的理解；2)扩展跨学科研究，拓宽我们对与发育暴露相关的健康风险和与疾病相关的潜在分子机制的理解；3)建立跨领域的桥梁，创造新的跨学科研究，培训和指导机会；4)有效沟通潜在的健康危害，并将基础研究成果转化为公共卫生的利益。行政核心将通过发展组织结构和建立形成中心成员、临床医生、研究人员、公众、NIEHS工作人员以及其他儿童环境卫生中心和形成中心之间的沟通机制，发挥方案中心的作用。负责的财政和资源管理将是首席研究员的主要职责，项目经理将予以协助。行政核心将追求这些具体目标：

Description (provided by applicant): The primary objective of the Administrative Core is to promote, organize and facilitate the interdisciplinary research and core activities of the Formative Center. The Program Director/Principal Investigator will provide leadership, supervision and organizational control in a manner that best utilizes the team's talents and skills towards four programmatic objectives: 1) provide leadership and innovation in basic and clinical research that furthers our understanding of environmental stressors and their impact on fetal development, 2) expand interdisciplinary research that broadens our understanding of the health risks associated with developmental exposures and the underlying molecular mechanisms associated with disease, 3) build bridges across fields and create new interdisciplinary research, training, and mentoring opportunities, and 4) effectively communicate the potential health hazards and translate the basic research findings for the benefit of public health. The Administrative Core will function as the hub of the program by developing the organizational structure and creating mechanisms for communication among the members of the Formative Center, with clinicians, with researchers, with the public, with NIEHS staff, and with other Children's Environmental Health Centers and Formative Centers. Responsible fiscal and resource management will be the primary responsibility of the Principal Investigator, aided by the Program Manager. The Administrative Core will pursue these Specific Aims: Specific Aim 1: Provide, support and develop processes that sustain and accommodate the growth of interdisciplinary basic and applied research and training. Specific Aim 2: Maintain a communication structure that strengthens team building and facilitates the dissemination of information. Specific Aim 3: Implement mechanisms that will optimally promote the program's objectives and ensure the best and most responsible use of the available resources. Public Health Relevance: The over-arching goal of this Formative Center is to develop novel biomarkers for the adverse effects of environmental exposures that impact fetal development and produce childhood and adult disease. Using an interdisciplinary approach, research, educational, and training interventions will be designed to address the concerns that pregnant women, families, and communities have about environmental chemicals and the health of their developing children.