Skeletal Physiology Dysregulation in Obesity: The Role of Growth Hormone

肥胖引起的骨骼生理失调：生长激素的作用

• 批准号: 8506712
• 负责人: Miriam Antoinette Bredella
• 金额: $ 65.82万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-08 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8506712
• 关键词: Adipocytes; Aging; Apolipoproteins B; Body Composition; Bone Density; Bone Marrow; Bone Marrow Stem Cell; C-reactive protein; Complication; Data; Deposition; Development; Dose; Endocrinologist; Endocrinology; Epidemic; Fatty acid glycerol esters; Finite Element Analysis; Fracture; Functional Imaging; Functional disorder; Homeostasis; Hormones; Imaging Techniques; Inflammatory; Insulin; Insulin-Like Growth Factor I; Investigation; Joints; Lead; Lipids; Lipoproteins; Liver; Mediating; Mediator of activation protein; Menopause; Mesenchymal; Muscle; Musculoskeletal System; Normal Range; Obesity; Osteoblasts; Osteocalcin; Osteogenesis; Osteoporosis; Pathogenesis; Pathway interactions; Pharmaceutical Preparations; Physiological; Physiology; Pituitary Gland; Play; Population; Prevalence; Public Health; Publishing; Radiology Specialty; Regulation; Relative (related person); Research; Research Personnel; Risk Factors; Role; Serum; Somatotropin; Structure; System; Techniques; Thick; Time; Vitamin D; Vitamin D2; Weight; Woman; abdominal fat; base; bone; bone health; bone loss; bone mass; bone strength; cytokine; experience; improved; insight; interest; men; muscle form; new therapeutic target; novel; osteoblast differentiation; patient oriented research; public health relevance; radiologist; skeletal; stem cell differentiation; wasting

DESCRIPTION (provided by applicant): Obesity is an important risk factor for osteoporosis and fractures. With the growing prevalence of obesity in the U.S., understanding the pathophysiology of bone loss in this population is of importance to public health. Growth hormone (GH) is a critical mediator of bone homeostasis and is markedly reduced in obesity. Our preliminary data suggest an important role for the GH/insulin-like growth factor 1 system in the pathogenesis of bone loss in obesity. The development of novel imaging techniques provides an opportunity to investigate the effects of GH on skeletal structure and strength, which will provide insights into the pathogenesis of obesity related bone loss. Understanding the pathophysiology of bone loss in obesity may help identify new treatment targets for this important complication. We have assembled a team of investigators with extensive experience in patient-oriented research in endocrinology and radiology to perform these investigations.

描述（由申请人提供）：肥胖是骨质疏松症和骨折的重要危险因素。随着美国肥胖症的日益流行，了解这一人群中骨丢失的病理生理学对公众健康具有重要意义。生长激素（GH）是骨稳态的关键介质，在肥胖症中显著降低。我们的初步数据表明，GH/胰岛素样生长因子1系统在肥胖症骨丢失的发病机制中起重要作用。新型影像学技术的发展为研究生长激素对骨骼结构和强度的影响提供了机会，这将为肥胖相关骨丢失的发病机制提供新的见解。了解肥胖症中骨丢失的病理生理学可能有助于确定这一重要并发症的新治疗靶点。我们已经组建了一个在内分泌学和放射学以患者为导向的研究方面具有丰富经验的研究人员团队来进行这些研究。