A Novel Diet-Phenotype Interaction Affecting Body Weight

影响体重的新型饮食-表型相互作用

基本信息

批准号：
8528565
负责人：
DAVID S LUDWIG
金额：
$ 59.33万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8528565
关键词：
2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole Abdomen Affect Animals Attention Behavior Behavioral Biological Biological Factors Blood Pressure Body Weight Body Weight decreased Body fat Boston C-reactive protein Carbohydrates Classification Counseling Diabetes Mellitus Diet Dietary intake Dietitian Dual-Energy X-Ray Absorptiometry Educational workshop Enrollment Fat-Restricted Diet Fatty acid glycerol esters Fostering Glucose High Density Lipoprotein Cholesterol Hour Human Hunger Individual Individual Differences Ingestion Insulin Intervention Interview LDL Cholesterol Lipoproteins Measurement Measures Metabolic syndrome Methods Molecular Molecular Analysis Molecular Profiling Motivation North Carolina Nutritional Support Obesity Observational Study Oral Outcome Participant Pediatric Hospitals Phenotype Physical activity Physiological Plasma Plasminogen Activator Inhibitor 1 Play Population Decreases Process Measure Proteins Protocols documentation Psychological Factors Randomized Randomized Controlled Trials Reproducibility Research Risk Factors Role Scanning Schedule Serum Site Telephone Testing Translations Triglycerides Universities Variant Waist-Hip Ratio Weight Work abdominal fat base cardiovascular risk factor clinical application clinical practice computerized data processing diabetes risk follow-up improved insight insulin mediators insulin secretion insulin sensitivity meetings metabolomics novel nutrition education obesity treatment public health relevance response satisfaction young adult

项目摘要

DESCRIPTION (provided by applicant): In recent years, diets of widely varying composition have been used in the treatment of obesity. While none of these diets has produced consistent, long-term weight loss, some individuals on virtually all types of diets do remarkably well. One explanation for this variation among individuals is differences in motivation and behavior. However, underlying biological differences may also play an important role. Previous work has identified insulin secretion (as quantified by serum insulin concentration at 30 minutes following a standard 75-gram oral glucose load) as an important biological determinant. This randomized-controlled, multi-center trial aims to test the hypothesis that insulin secretion will predict which type of diet will work best for each individual. A total of 160 obese young adults (18 to 40 years) will be assigned to one of two diets: low-fat (60% carbohydrate, 20% fat, 20% protein) or low-glycemic load (45% carbohydrate, 35% fat, 20% protein). Participants will be enrolled at two sites (Children's Hospital Boston or University of North Carolina-Chapel Hill) and assigned to diet groups according to baseline insulin secretion status. The protocol will include an intensive 6-month intervention period and a 12-month follow-up period. Registered dietitians will provide nutrition education and behavioral counseling during group workshops and scheduled telephone calls. In an effort to avoid confounding, close attention will be paid to control for treatment intensity, physical activity prescriptions, and behavioral methods between groups. The primary endpoint will be percent body fat by DXA scan. Secondary endpoints will include cardiovascular and diabetes risk factors. Repeated, 24-hour dietary and physical activity recall interviews will provide process data. Metabolomic profiling and molecular analysis of identified metabolites will be conducted to characterize phenotype and explore potential physiological mechanisms.

描述（由申请人提供）：近年来，肥胖症的饮食已使用广泛变化的饮食。尽管这些饮食都没有产生一致的长期体重减轻，但一些人几乎所有类型的饮食都做得很好。个人之间这种差异的一种解释是动机和行为的差异。但是，潜在的生物学差异也可能起重要作用。先前的工作已将胰岛素分泌（通过标准75克口服葡萄糖负荷后30分钟的血清胰岛素浓度量化）为重要的生物学决定因素。这项随机控制的多中心试验旨在检验胰岛素分泌将预测哪种饮食最适合每个人的假设。共有160名肥胖年轻人（18至40岁）将分配给两种饮食之一：低脂（60％碳水化合物，20％脂肪，20％蛋白质）或低血糖载荷（45％碳水化合物，35％脂肪，20％蛋白质）。参与者将在两个地点（波士顿儿童医院或北卡罗来纳大学 - 教堂山）的两个地点招收，并根据基线胰岛素分泌状态分配给饮食组。该协议将包括一个密集的6个月干预期和12个月的随访期。注册营养师将在小组讲习班和预定电话期间提供营养教育和行为咨询。为了避免混淆，将密切注意以控制治疗强度，体育锻炼处方和组之间的行为方法。 DXA扫描的主要终点为体内脂肪百分比。次要终点将包括心血管和糖尿病风险因素。重复的24小时饮食和体育锻炼召回访谈将提供过程数据。将对已鉴定的代谢产物的代谢组分析和分子分析进行表征表征并探索潜在的生理机制。