Effects of Diet on Hormones, Metabolism and Body Weight

饮食对激素、新陈代谢和体重的影响

• 批准号: 7574700
• 负责人: DAVID S LUDWIG
• 金额: $ 15.9万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7574700
• 关键词: Adolescent; Area; Arts; Body Weight; Body Weight decreased; Boston; Carbohydrates; Cardiovascular Diseases; Childhood; Clinic; Clinical; Clinical Research; Consumption; Country; Diet; Doctor of Philosophy; Effectiveness; Environment; Faculty; Fatty acid glycerol esters; Goals; Grant; Hormonal; Hospitals; Human; Intervention; Life Expectancy; Medical Students; Mentors; Metabolism; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Patients; Pediatric Hospitals; Prevalence; Prevention approach; Publications; Regulation; Research; Research Personnel; Risk; Scientist; Taxes; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Work; base; clinical material; conventional therapy; cost; feeding; hormone metabolism; medical schools; next generation; novel strategies; nutrition; obesity in children; obesity treatment; patient oriented research; prevent; programs; public health relevance; response; sugar; sweetened beverage; young adult

DESCRIPTION (provided by applicant): The prevalence of obesity in children and young adults has increased dramatically in recent years. However, conventional treatment has had poor long-term effectiveness. The short-term goal of this application is to provide David Ludwig, MD, PhD, a nationally-recognized expert in childhood obesity, protected time to mentor junior investigators in patient-oriented research. Dr. Ludwig has a track record of high quality scientific publications, completed and current NIH grants, and mentoring. He is founding director of one of the country's oldest and largest pediatric obesity clinics, and co-director of a new, hospital-wide translational research program in pediatric obesity. The long-term scientific goal of this project is to examine the effects of dietary composition on hormonal response, metabolism, body weight regulation and risk for type 2 diabetes and cardiovascular disease. The proposed research includes three Specific Aims: 1) a feeding study comparing low fat, very low carbohydrate and low glycemic load diets after weight loss; 2) a 2- year RCT of diet in the treatment of obesity in children; and 3) a 2-year RCT examining the effects of reducing sugar-sweetened beverage consumption on body weight in obese adolescents. The long-term mentoring goal of this project is to help train clinical scientists in the areas of pediatric obesity and nutrition by providing opportunities at all levels (undergraduate, medical student, resident, fellow and junior faculty) to work on state-of-the-art clinical research ranging from mechanistically oriented feeding studies to environmentally-based interventions. The research environment is ideal to support these goals, including the presence of a General Clinical Research Center at Children's Hospital Boston and a K30 training program at Harvard Medical School (with an application for CTSC pending), outstanding access to patients and clinical materials, and an exciting intellectual environment with numerous clinical and basic investigators working in related areas. PUBLIC HEALTH RELEVANCE: Childhood obesity threatens to shorten life-expectancy in the US and cost tax-payers many trillions of dollars over the next few decades. To prevent this potentially catastrophic fiscal and human toll, novel approaches to the prevention and treatment of obesity are needed, and the next generation of clinical scientists with expertise in pediatric obesity must be trained. This application will support the ability of Dr. Ludwig, a midcareer clinician-scientist with an outstanding track record, to contribute in these two areas.

描述（由申请人提供）： 近年来，儿童和年轻人肥胖症的患病率急剧增加。然而，常规治疗的长期效果不佳。本申请的短期目标是为全国公认的儿童肥胖症专家大卫路德维希医学博士提供受保护的时间，以指导以患者为导向的研究中的初级研究人员。路德维希博士有高质量的科学出版物，完成和当前NIH赠款和指导的跟踪记录。他是全国最古老、最大的儿童肥胖症诊所之一的创始主任，也是一个新的、全院范围的儿童肥胖症转化研究项目的联合主任。该项目的长期科学目标是研究饮食组成对激素反应，代谢，体重调节以及2型糖尿病和心血管疾病风险的影响。拟议的研究包括三个具体目标：1）一项喂养研究，比较减肥后的低脂、极低碳水化合物和低血糖负荷饮食; 2）一项为期2年的饮食治疗儿童肥胖的RCT; 3）一项为期2年的RCT，检查减少含糖饮料消费对肥胖青少年体重的影响。该项目的长期指导目标是通过提供各级（本科生，医科学生，居民，研究员和初级教师）的机会，帮助培训儿科肥胖和营养领域的临床科学家，从事最先进的临床研究，从机械导向的喂养研究到环境干预。研究环境是支持这些目标的理想选择，包括波士顿儿童医院的综合临床研究中心和哈佛医学院的K30培训计划（正在申请CTSC），优秀的患者和临床材料，以及令人兴奋的知识环境，众多临床和基础研究人员在相关领域工作。 公共卫生关系：儿童肥胖威胁着美国人的预期寿命，并在未来几十年内花费纳税人数万亿美元。为了防止这种潜在的灾难性的财政和人力损失，需要新的方法来预防和治疗肥胖症，并且必须培训具有儿科肥胖症专业知识的下一代临床科学家。Ludwig博士是一位职业生涯中期的临床科学家，拥有出色的业绩记录，他将在这两个领域做出贡献。