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Effects of Diet on Hormones, Metabolism and Body Weight

饮食对激素、新陈代谢和体重的影响

基本信息

批准号：
8634981
负责人：
DAVID S LUDWIG
金额：
$ 10.3万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-01-01 至 2019-09-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8634981
关键词：
Adolescent Anti-Inflammatory Agents Anti-inflammatory Area Asthma Award Behavioral Beverages Birth Weight Blood Glucose Blood Pressure Body Weight Body Weight decreased Body Weights and Measures Boston Carbohydrates Cereals Child Childhood Chronic Chronic Disease Clinical Clinical Research Clinical Trials Consumption Cross-Over Studies Diabetes Mellitus Diet Dietary Factors Dietary Fiber Disease remission Doctor of Philosophy Dual-Energy X-Ray Absorptiometry Effectiveness Energy Metabolism Environment Excretory function Faculty Family Fasting Fat-Restricted Diet Fatty acid glycerol esters Fiber Food Processing Forced expiratory volume function Genetic Glycemic Index Goals Grant Health Heart Diseases High Density Lipoprotein Cholesterol Home environment Human Hydrocortisone Illness Days Immunity Incidence Indirect Calorimetry Individual Infant Infection Inflammation Insulin Insulin Resistance Knowledge Life Expectancy Life Style Low-Density Lipoproteins Macronutrients Nutrition Maintenance Malignant Neoplasms Medical Students Mentors Metabolic syndrome Milk Non-Insulin-Dependent Diabetes Mellitus Nutrient OGTT Obesity Omega-3 Fatty Acids Outcome Outpatients Overnutrition Overweight Patients Pediatric Hospitals Pharmaceutical Preparations Phytochemical Postdoctoral Fellow Pregnancy Preparation Prevalence Prevention approach Principal Investigator Process Publishing Pulmonary Function Test/Forced Expiratory Volume 1 Recommendation Regulation Research Research Personnel Rest Risk Risk Factors Rotation Sampling Scanning Scientist Taste Perception Taxes Testing Time Training Triglycerides Water Weight Weight Gain Work arm career development catalyst clinical material conventional therapy cost design disorder prevention disorder risk electric impedance experience feeding graduate student hormone metabolism improved insulin secretion interest lifestyle intervention next generation novel novel strategies nutrition obesity in children obesity prevention obesity treatment offspring patient oriented patient oriented research preference premature prenatal prevent prospective public health relevance research study response stable isotope standard care sugar young adult

项目摘要

SUMMARY The prevalence of obesity in children has increased dramatically in recent years. However, conventional treatment has had poor long-term effectiveness. The short-term goal of this competitive renewal application is to provide protected time for the Principal Investigator, David Ludwig, MD, PhD, for an additional 5 years of mentoring and patient-oriented research. During the first period of support, Dr. Ludwig had primary responsibility for the training of 10 full-time graduate students, post-doctoral fellows and junior faculty. In addition, he supervised 14 other individuals for research rotations or career development. A total of 34 scientific articles (including 17 original research studies) were published during the first 4 years of the award period, with additional articles submitted or in preparation. Two new R01 grants were obtained during the initial award period that, together with other ongoing or available studies, provide outstanding opportunities for training junior investigators. The long-term mentoring goal of this project is to help train clinical scientists in the areas of pediatric obesity and nutrition by providing opportunities at all levels (undergraduate, medical student, resident, fellow and junior faculty) to work on state-of-the-art clinical research. The long-term scientific goals are to explore the effects of specific dietary factors on body weight regulation and risk for type 2 diabetes and heart disease, and use these findings to design more effective approaches to obesity treatment and chronic disease prevention. The specific dietary factors of interest include macronutrient composition, glycemic index, fiber, dairy, beverage consumption, food processing and prenatal diet. Toward this end, we will employ controlled feeding study (Specific Aim #1), behaviorally-oriented outpatient clinical trials (Specific Aim #2) and prospective observational analyses (Specific Aim #3). The research environment is ideal to support these goals, including the presence of the Harvard CTSA ("The Catalyst"), the recent establishment of the Obesity Prevention Center at Boston Children's Hospital, the existence of numerous institutional training grants, outstanding access to patients and clinical materials, and an exciting intellectual environment with clinical and basic investigators working in related areas.

总结