Maintaining Resistance Training in Older Prediabetic Adults: Theoretical Approach
老年糖尿病前期患者维持阻力训练:理论方法
基本信息
- 批准号:8531226
- 负责人:
- 金额:$ 56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-01 至 2015-07-31
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAdherenceAdultAerobicAffectAgingAreaBehavior TherapyBehavioralBeta CellBody Weight decreasedC-PeptideCellsClinical TrialsCommunitiesDataDiabetes MellitusDiabetes preventionDigestive System DisordersDiseaseElderlyExerciseExhibitsFamilyFatty acid glycerol estersGeneric DrugsGlucoseGlycogen (Starch) SynthaseHealthHealth BenefitHealthy People 2010HomeostasisImpaired fasting glycaemiaIndividualInformal Social ControlInstitutesInsulinInterventionInvestmentsKidney DiseasesMaintenanceMeasuresMediatingMetabolicModalityModelingMuscleNational Institute of Diabetes and Digestive and Kidney DiseasesNon-Insulin-Dependent Diabetes MellitusOralOutcomeOutcome MeasurePhasePhase II Clinical TrialsPhysical activityPopulationPrediabetes syndromePrevalencePrevention ResearchPrevention strategyPropertyProtocols documentationPublic HealthRandomizedReportingResearchResistanceRiskSLC2A1 geneSelf EfficacySpecificitySupervisionTimeTrainingWomanWorkagedbaseblood glucose regulationdensitydisabilitydisorder preventionfasting glucosefitnessglucose toleranceimpaired glucose toleranceimprovedinclusion criteriaindexinginsulin sensitivitymeetingsmenprimary outcomeprogramssarcopeniaskillssocial cognitive theorystrength trainingtheories
项目摘要
DESCRIPTION (provided by applicant): The aim of this Phase II Clinical Trial is to demonstrate the efficacy of social cognitive theory (SCT) based intervention for initiating, and most importantly, maintaining resistance training in older adults with pre-diabetes (i.e., impaired glucose tolerance or impaired fasting glucose) to improve glucose homeostatis. The overall aim is consistent with NIDDK's Behavioral/Prevetion Research Program's forcus on individual, family, and community-based strategies for prevention of diabetes and its complications. Resistance training is particularly applicable to older, prediabeteic adults given the loss of lean body mass and worsening of glucose tolerance with aging. The proposed research program evaluates a 15-month SCT based intervention for maintenance of resistance training with older adults. Men and women 50-69 (N=220) with pre-diabetes, defined as exhibiting either impaired glucose tolerance (IGT; 2-h glucose 140-199 mg/dl) or impaired fasting glucose (IFG; 100-125 mg/dl), will first follow the same standard, supervised 3-month initiation period with resistance training. All people completing the Initial Phase will be randomly assigned to 1 of 3 maintenance conditions: 1. a long-term SCT based, ASPIRE intervention, emphasizing self-regulation and other SCT strategies to optimize training, with faded contact; 2. a long-term Generic intervention lacking a number of SCT components but with the same faded contact, or, 3. a Standard intervention with more minimal contact. The primary outcome measures are indices of pre-diabetes (glucose tolerance and fasting glucose concentration) and strength. Secondary measures include adherence; ss-cell responsivity, insulin sensitivity, and disposition index, as determined by the oral glucose and C-peptide minimal model; fat free mass, other indicators of health and metabolic fitness, and SCT measures. Assessments will occur at baseline, at the end of the Initiation Phase (3 months), at the end of the different interventions (9 months) and 6 months after all contact has ended (15 months from baseline). It is hypothesized that SCT based resistance training with faded contact will produce better outcomes than Generic based training with faded contact, which in turn, will produce better outcomes than Standard-based resistance training at 9 month and 15 month assessments. It also is hypothesized that improvements in glucose homeostasis and in strength from resistance training will be mediated by adherence, self-efficacy, and use of self-regulation strategies. Resistance training has become an important component in the treatment and prevention of diseases and disabilites, and especially so for Type 2 diabetes. Critical to public health and a focus of NIDDK are theory-based interventions that enable, effective long-term resistance training with minimal supervision after an initiation phase and where improvements in adherence and outcomes are facilitated by theoretical constructs.
描述(由申请人提供):本II期临床试验的目的是证明基于社会认知理论(SCT)的干预在糖尿病前期老年人(即,葡萄糖耐量受损或空腹葡萄糖受损)以改善葡萄糖稳态。总体目标与NIDDK的行为/预防研究计划的重点是预防糖尿病及其并发症的个人,家庭和社区为基础的战略是一致的。鉴于随着年龄的增长,瘦体重会减少,葡萄糖耐量会恶化,阻力训练特别适用于老年糖尿病前期成年人。拟议的研究计划评估了一个15个月的SCT为基础的干预维持阻力训练与老年人。患有糖尿病前期的男性和女性50-69(N=220),定义为表现出葡萄糖耐量受损(IGT; 2-h葡萄糖140-199 mg/dl)或空腹葡萄糖受损(IFG; 100-125 mg/dl),将首先遵循相同的标准,监督3个月的抗阻训练起始期。所有完成初始阶段的人将被随机分配到3个维护条件之一:1。基于长期SCT的ASPIRE干预,强调自我调节和其他SCT策略,以优化培训,淡化接触; 2.长期的一般干预缺乏一些SCT组件,但具有相同的褪色接触,或,3. a标准干预,接触更少。主要的结果指标是糖尿病前期(葡萄糖耐量和空腹血糖浓度)和力量指数。次要指标包括依从性; ss细胞反应性、胰岛素敏感性和处置指数,如通过口服葡萄糖和C肽最小模型确定的;去脂质量、健康和代谢适应性的其他指标以及SCT指标。将在基线、启动阶段结束时(3个月)、不同干预结束时(9个月)和所有联系结束后6个月(自基线起15个月)进行评估。假设在9个月和15个月的评估中,基于SCT的阻力训练和褪色接触将产生比基于通用的阻力训练和褪色接触更好的结果,而基于通用的阻力训练和褪色接触将产生比基于标准的阻力训练更好的结果。也有人假设,葡萄糖稳态和阻力训练的力量的改善将介导的坚持,自我效能和自我调节策略的使用。阻力训练已成为治疗和预防疾病和残疾的重要组成部分,尤其是2型糖尿病。对公共卫生至关重要,NIDDK的重点是基于理论的干预措施,这些干预措施能够在初始阶段后进行有效的长期阻力训练,并在理论结构的促进下改善依从性和结果。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Questionnaires for outcome expectancy, self-regulation, and behavioral expectation for resistance training among young-old adults: development and preliminary validity.
年轻老年人阻力训练的结果预期、自我调节和行为预期问卷:发展和初步有效性。
- DOI:10.1123/japa.2013-0184
- 发表时间:2015
- 期刊:
- 影响因子:1.5
- 作者:Williams,DavidM;Savla,Jyoti;Davy,BrendaM;Kelleher,SarahA;Marinik,ElainaL;Winett,RichardA
- 通讯作者:Winett,RichardA
Uncomplicated resistance training and health-related outcomes: evidence for a public health mandate.
- DOI:10.1249/jsr.0b013e3181e7da73
- 发表时间:2010-07
- 期刊:
- 影响因子:1.8
- 作者:Phillips SM;Winett RA
- 通讯作者:Winett RA
Theory-based approach for maintaining resistance training in older adults with prediabetes: adherence, barriers, self-regulation strategies, treatment fidelity, costs.
用于维持老年糖尿病前期患者阻力训练的基于理论的方法:依从性、障碍、自我调节策略、治疗保真度、成本。
- DOI:10.1007/s13142-015-0304-5
- 发表时间:2015
- 期刊:
- 影响因子:3.6
- 作者:Winett,RichardA;Davy,BrendaM;Savla,Jyoti;Marinik,ElainaL;Kelleher,SarahA;Winett,SheilaG;Halliday,TanyaM;Williams,DavidM
- 通讯作者:Williams,DavidM
Adapting the "Resist Diabetes" Resistance Training Intervention for Veterans.
- DOI:10.1249/tjx.0000000000000118
- 发表时间:2020-03
- 期刊:
- 影响因子:0.9
- 作者:VanDerBrink E;Boshra S;Harden SM;Oursler KK;Winett R;Davy B
- 通讯作者:Davy B
Resistance training is associated with spontaneous changes in aerobic physical activity but not overall diet quality in adults with prediabetes.
阻力训练与有氧运动的自发变化相关,但与糖尿病前期成人的整体饮食质量无关。
- DOI:10.1016/j.physbeh.2017.04.013
- 发表时间:2017
- 期刊:
- 影响因子:2.9
- 作者:Halliday,TanyaM;Savla,Jyoti;Marinik,ElainaL;Hedrick,ValisaE;Winett,RichardA;Davy,BrendaM
- 通讯作者:Davy,BrendaM
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BRENDA M DAVY其他文献
BRENDA M DAVY的其他文献
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{{ truncateString('BRENDA M DAVY', 18)}}的其他基金
Influence of ultra-processed foods on reward processing and energy intake
超加工食品对奖励加工和能量摄入的影响
- 批准号:
10670413 - 财政年份:2022
- 资助金额:
$ 56万 - 项目类别:
Influence of ultra-processed foods on reward processing and energy intake
超加工食品对奖励加工和能量摄入的影响
- 批准号:
10510728 - 财政年份:2022
- 资助金额:
$ 56万 - 项目类别:
Ultra-processed food consumption, gut microbiota, and glucose homeostasis in mid-life adults
中年成年人的超加工食品消费、肠道微生物群和葡萄糖稳态
- 批准号:
10618337 - 财政年份:2022
- 资助金额:
$ 56万 - 项目类别:
Ultra-processed food consumption, gut microbiota, and glucose homeostasis in mid-life adults
中年成年人的超加工食品消费、肠道微生物群和葡萄糖稳态
- 批准号:
10431451 - 财政年份:2022
- 资助金额:
$ 56万 - 项目类别:
d13C Added Sugar Intake Biomarker: Determining Validity in Children
d13C 添加糖摄入生物标志物:确定儿童的有效性
- 批准号:
8768638 - 财政年份:2014
- 资助金额:
$ 56万 - 项目类别:
Maintaining Resistance Training in Older Prediabetic Adults: Theoretical Approach
老年糖尿病前期患者维持阻力训练:理论方法
- 批准号:
8117501 - 财政年份:2009
- 资助金额:
$ 56万 - 项目类别:
Maintaining Resistance Training in Older Prediabetic Adults: Theoretical Approach
老年糖尿病前期患者维持阻力训练:理论方法
- 批准号:
8305745 - 财政年份:2009
- 资助金额:
$ 56万 - 项目类别:
Maintaining Resistance Training in Older Prediabetic Adults: Theoretical Approach
老年糖尿病前期患者维持阻力训练:理论方法
- 批准号:
7894584 - 财政年份:2009
- 资助金额:
$ 56万 - 项目类别:
Maintaining Resistance Training in Older Prediabetic Adults: Theoretical Approach
老年糖尿病前期患者维持阻力训练:理论方法
- 批准号:
7729633 - 财政年份:2009
- 资助金额:
$ 56万 - 项目类别:
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