Water Intake and Weight Control in Older Adults

老年人的饮水量和体重控制

• 批准号: 10582833
• 负责人: BRENDA M DAVY
• 金额: $ 69.18万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582833
• 关键词: Acute; Address; Adherence; Adult; American; Appetite Regulation; Area; Attention; Behavior; Behavioral Mechanisms; Body Weight decreased; Clinical; Clinical Practice Guideline; Cognition; Cognitive; Consumption; Control Groups; Dehydration; Desire for food; Diet; Disease; Elderly; Energy Intake; Esthesia; Evaluation; Face; Goals; Health Benefit; High Prevalence; Hormones; Hunger; Hydration status; Impaired cognition; Impairment; Instruction; Insulin; Intervention; Intervention Trial; Kidney Calculi; Link; Maintenance; Measures; Mediating; Mediator; Medical; Nutritional Study; Obesity; Osmolalities; Outcome; Overweight; Participant; Performance; Phase; Population; Randomized, Controlled Trials; Recommendation; Research; Satiation; Serum; Stomach; Strategic Planning; Time; United States National Institutes of Health; Urinary tract infection; Urine; Water; Water consumption; Weight; Weight Gain; Weight maintenance regimen; Woman; adult obesity; aged; attentional control; cognitive function; comparison control; cost; dietary; dietary adherence; dietary guidelines; disability risk; drinking water; efficacy study; evidence base; evidence based guidelines; executive function; fasting glucose; healthy lifestyle; improved; lifestyle intervention; men; middle age; obesity risk; obesity treatment; overweight adults; prevent; randomized controlled design; success; treatment as usual; trial design; usual care arm; weight maintenance; working group

Project Summary/Abstract The lack of practical and effective strategies to manage hunger and adhere to a weight management intervention represents a critical barrier to the weight management field. In proof-of-concept efficacy studies, we have demonstrated that premeal water consumption (500 ml) acutely reduced perceived hunger and meal energy intake among middle-aged and older adults, and that premeal water consumption (500 ml, 3 times per day) increased the amount of weight lost (i.e., 2 kg greater loss) after 12 weeks among middle-aged and older adults with overweight or obesity. However, water consumption may be important for weight management regardless of when it is consumed. To address this possibility, we propose a rigorously-designed randomized controlled intervention trial in adults aged 50+ years with overweight or obesity comparing three groups with different diet prescriptions: 1) pre-meal water consumption (500 ml, before each main meal) with a hypocaloric diet; 2) 1500 ml water consumed throughout the day with a hypocaloric diet; 3) hypocaloric diet with no instructions regarding water consumption. Smart water bottles will objectively assess water intake timing and volume. Urine osmolality, urine volume, and serum osmolality will be used as objective indicators of compliance with the water intake prescription. We will investigate changes in perceived hunger and fullness and appetite-regulating hormones as potential mechanisms by which premeal water could improve appetite regulation. We will also investigate the impact of water consumption and hydration on executive function capabilities, which may influence intervention adherence. We hypothesize that weight loss at 12 weeks, and weight loss maintenance at 12 months, will be greater in the premeal water group compared to the daily water volume and control groups. Furthermore, when combined with a hypocaloric diet, premeal water will reduce hunger and increase fullness; these changes will mediate adherence to the hypocaloric diet and weight loss outcomes. Although increasing water intake could be an effective weight management strategy, no evidence-based recommendations exist for the timing of water intake needed for this benefit. Our findings could identify a low-cost, actionable dietary strategy that could be incorporated into clinical practice guidelines for obesity treatment, and improve adherence to a hypocaloric diet prescription through reduced hunger, increased fullness, and improved attention and inhibitory control. This proposal is aligned with the 2020-2030 NIH Strategic Plan for Nutrition Research (Objective 3.5) and the Dietary Guidelines for Americans 2020-2025 due to its focus on older adults, an understudied population at increased risk for obesity and inadequate hydration. If effective, this hydration/weight control intervention approach could be applied to clinical populations such as adults with obesity who are prescribed increased water intake to prevent or treat kidney stone disease or urinary tract infections, which are common in older adults.

项目概要/摘要 缺乏实用有效的策略来管理饥饿和坚持体重管理干预措施 是体重管理领域的一个关键障碍。在概念验证功效研究中，我们有 研究表明，餐前饮水（500 毫升）可显着降低感知饥饿感和膳食能量 中老年人摄入量及餐前饮水量（500毫升，每日3次） 12周后中老年人的体重减轻量增加（即增加2公斤） 超重或肥胖。然而，无论怎样，水的消耗对于体重管理可能很重要 消耗的时间。为了解决这种可能性，我们提出了严格设计的随机对照 对 50 岁以上超重或肥胖成年人进行的干预试验，比较三组不同饮食的人 处方：1）餐前饮水（每顿主餐前500毫升）配合低热量饮食； 2）1500 低热量饮食全天消耗的毫升水； 3）低热量饮食，没有任何说明 耗水量。智能水瓶将客观地评估饮水时间和饮水量。尿液渗透压， 尿量和血清渗透压将作为水摄入依从性的客观指标 处方。我们将调查感知饥饿感和饱腹感以及食欲调节激素的变化 餐前水可以改善食欲调节的潜在机制。我们还将调查 水消耗和水合作用对执行功能的影响，这可能会影响干预 坚持。我们假设 12 周时减重和 12 个月时维持减重将是 与每日饮水量和对照组相比，餐前饮水组的饮水量更大。此外，当 与低热量饮食相结合，餐前喝水可以减少饥饿感并增加饱腹感；这些变化将 介导对低热量饮食的坚持和减肥结果。虽然增加饮水量可能会 有效的体重管理策略，对于喝水的时间没有基于证据的建议 此益处所需的摄入量。我们的研究结果可以确定一种低成本、可行的饮食策略 纳入肥胖治疗的临床实践指南，并提高对低热量饮食的依从性 通过减少饥饿、增加饱腹感以及改善注意力和抑制控制来进行处方。这 该提案与 2020-2030 年 NIH 营养研究战略计划（目标 3.5）和饮食保持一致 2020-2025 年美国人指南，因为它重点关注老年人，这是一个未得到充分研究的人群 肥胖和水分不足的风险。如果有效，这种水合/体重控制干预方法可以 适用于临床人群，例如患有肥胖症的成年人，他们被要求增加饮水量 预防或治疗老年人常见的肾结石病或尿路感染。