A Gene Expression Brain Atlas of the Zebra Finch.
斑胸草雀的基因表达脑图谱。
基本信息
- 批准号:8444464
- 负责人:
- 金额:$ 37.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-04-01 至 2015-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAgeAnimal ModelApoptosisAreaAtlasesBehaviorBioinformaticsBirdsBrainBrain MappingBrain regionCell Cycle RegulationCell NucleusCell divisionChickensComparative Genomic AnalysisComplexConsultationsDataDatabasesDevelopmentDiseaseEndogenous FactorsEnvironmental Risk FactorEnzymesExpressed Sequence TagsFundingFutureGene ExpressionGene Expression ProfileGene Expression RegulationGene FamilyGene StructureGene Transfer TechniquesGenesGeneticGenomeGenomicsGoalsGonadal Steroid HormonesGrantGrowthGrowth FactorHealthHormonalHormonesHumanImpairmentIndividualIon ChannelKnock-outKnowledgeLanguage DevelopmentLearningLibrariesLinkLiteratureMammalsMapsModelingMolecularMolecular GeneticsMolecular ProfilingMusNational Human Genome Research InstituteNational Institute of Neurological Disorders and StrokeNerve Growth Factor ReceptorsNeurobiologyNeuromodulatorNeuronsNeurosecretory SystemsNeurotransmitter ReceptorNeurotransmittersNuclearNutritionalOnline SystemsOrganismPhysiological ProcessesPlayProductionPropertyReceptor CellReceptor GeneRegulationReproductive BehaviorResearchResearch PersonnelResourcesRoleSeriesShapesSiteSleepSocial BehaviorSongbirdsSpeechStructureSynapsesSystemUnited States National Institutes of Healthbasebird songcDNA Librarycomparativecomparative genomicsdeafnessdeep sequencingdigitalhigh throughput analysisimprovedinsightinterestmalemolecular markerneurochemistryneurogenesisneuronal excitabilityneuronal replacementnovelphotoperiodicitypromoterpublic health relevancereceptorrelating to nervous systemresearch studyscreeningsexsexual dimorphismtooltraittranscription factortransgene expressionvocal learningvocalizationzebra finch
项目摘要
DESCRIPTION (provided by applicant): Songbirds are a leading model of neurobiological research with wide implications for understanding issues of human health and disease. They are among the few organisms that have evolved vocal learning, a complex trait that provides the basis of spoken language acquisition in humans. Studies of the ontogeny of songbird vocalizations and the organization of the brain circuitry that controls song learning and production have provided unique opportunities for uncovering the neural bases of vocal learning. Songbird research has also contributed novel insights into a broad range of fundamental questions in neurobiology, such as behaviorally- regulated gene expression, sex dimorphisms and the effects of sex steroids on brain structure and function, photoperiodicity and the regulation of seasonal brain plasticity, the role of sleep in learning, the neuroendocrine regulation of reproductive and social behaviors, and neurogenesis and neuronal replacement in adulthood. To help understand how the song control circuitry and birdsong behavior are shaped by genetic mechanisms, a wide set of modern molecular and genomic resources have recently become available to songbird researchers through NIH-funded initiatives; such resources include normalized brain cDNA libraries, comprehensive annotated EST databases, microarrays, a BAC library and the completed the zebra finch genome. Such resources have been instrumental in the rapid identification of genes and gene families of neurobiological interest, the study of gene structure and regulatory domains, high- throughput analysis of gene regulation through molecular profiling studies, and comparative genomics across the major higher vertebrate groups. A key next step in making full use of these genomic resources and understanding how genes relate to brain function and behavior in songbirds is to map gene expression in the context of functional brain circuits. To achieve this goal, we propose a single Specific Aim, namely to generate a Gene Expression Brain Atlas of the Zebra Finch. Specifically we propose to map the brain expression of a large set of genes (~2,500) that are of key importance to songbird and avian brain researchers, in register with a histological atlas, and make the data available as a web-based resource.
描述(由申请人提供):鸣禽是神经生物学研究的领先模型,对理解人类健康和疾病问题具有广泛意义。它们是少数几种进化出声音学习的生物之一,声音学习是一种复杂的特征,为人类的口语习得提供了基础。对鸣禽发声的个体发育和控制歌曲学习和产生的大脑回路组织的研究为揭示声乐学习的神经基础提供了独特的机会。鸣禽研究还为神经生物学中广泛的基本问题提供了新的见解,例如行为调控的基因表达,性别二型和性类固醇对大脑结构和功能的影响,光周期性和季节性大脑可塑性的调节,睡眠在学习中的作用,生殖和社会行为的神经内分泌调节,以及成年期的神经发生和神经元替代。为了帮助理解鸣禽的鸣唱控制电路和鸣禽的鸣唱行为是如何通过遗传机制形成的,通过NIH资助的计划,鸣禽研究人员最近可以获得一系列现代分子和基因组资源;这些资源包括标准化的大脑cDNA文库,全面注释的EST数据库,微阵列,BAC文库和完整的斑胸草雀基因组。这些资源有助于快速鉴定神经生物学感兴趣的基因和基因家族、研究基因结构和调控结构域、通过分子谱研究进行基因调控的高通量分析以及跨主要高等脊椎动物群体的比较基因组学。充分利用这些基因组资源并了解基因如何与鸣禽的大脑功能和行为相关的关键下一步是在功能性大脑回路的背景下绘制基因表达图。为了实现这一目标,我们提出了一个单一的具体目标,即产生一个基因表达大脑图谱的斑胸草雀。具体来说,我们建议绘制一组对鸣禽和鸟类大脑研究人员至关重要的基因(约2,500个)的大脑表达,与组织学图谱相结合,并将数据作为基于网络的资源提供。
项目成果
期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Proper care, husbandry, and breeding guidelines for the zebra finch, Taeniopygia guttata.
- DOI:10.1101/pdb.prot084780
- 发表时间:2014-10-23
- 期刊:
- 影响因子:0
- 作者:Olson CR;Wirthlin M;Lovell PV;Mello CV
- 通讯作者:Mello CV
An optimized protocol for high-throughput in situ hybridization of zebra finch brain.
- DOI:10.1101/pdb.prot084582
- 发表时间:2014-10-23
- 期刊:
- 影响因子:0
- 作者:Carleton JB;Lovell PV;McHugh A;Marzulla T;Horback KL;Mello CV
- 通讯作者:Mello CV
Living without DAT: Loss and compensation of the dopamine transporter gene in sauropsids (birds and reptiles).
- DOI:10.1038/srep14093
- 发表时间:2015-09-14
- 期刊:
- 影响因子:4.6
- 作者:Lovell PV;Kasimi B;Carleton J;Velho TA;Mello CV
- 通讯作者:Mello CV
No small feat: microRNA responses during vocal communication in songbirds.
这是一项不小的壮举:鸣禽声音交流过程中的 microRNA 反应。
- DOI:10.1186/1741-7007-9-35
- 发表时间:2011
- 期刊:
- 影响因子:5.4
- 作者:Mello,ClaudioV;Lovell,PeterV
- 通讯作者:Lovell,PeterV
The opportunities and challenges of large-scale molecular approaches to songbird neurobiology.
鸣禽神经生物学大规模分子方法的机遇和挑战。
- DOI:10.1016/j.neubiorev.2014.09.017
- 发表时间:2015
- 期刊:
- 影响因子:8.2
- 作者:Mello,CV;Clayton,DF
- 通讯作者:Clayton,DF
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Claudio V Mello其他文献
Automatic recognition and statistical quantification of spatial patterns of gene expression in zebra finch brain in response to auditory stimulation
- DOI:
10.1186/1471-2202-9-s1-p68 - 发表时间:
2008-07-11 - 期刊:
- 影响因子:2.300
- 作者:
Ovidiu D Iancu;Tarciso Velho;Patrick Roberts;Claudio V Mello - 通讯作者:
Claudio V Mello
Claudio V Mello的其他文献
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{{ truncateString('Claudio V Mello', 18)}}的其他基金
Transition Support for ZEBrA, A Gene Expression Brain Atlas of the Zebra Finch
对斑胸草雀基因表达脑图谱 ZEBrA 的过渡支持
- 批准号:
9164865 - 财政年份:2016
- 资助金额:
$ 37.15万 - 项目类别:
A Gene Expression Brain Atlas of the Zebra Finch.
斑胸草雀的基因表达脑图谱。
- 批准号:
8245200 - 财政年份:2010
- 资助金额:
$ 37.15万 - 项目类别:
A Gene Expression Brain Atlas of the Zebra Finch.
斑胸草雀的基因表达脑图谱。
- 批准号:
8052763 - 财政年份:2010
- 资助金额:
$ 37.15万 - 项目类别:
A Gene Expression Brain Atlas of the Zebra Finch.
斑胸草雀的基因表达脑图谱。
- 批准号:
7873564 - 财政年份:2010
- 资助金额:
$ 37.15万 - 项目类别:
Estrogens and Central Auditory Processing of Birdsong
雌激素与鸟鸣的中枢听觉处理
- 批准号:
7599287 - 财政年份:2008
- 资助金额:
$ 37.15万 - 项目类别:
Molecular Profiling of Song Nucleus HVC in the Zebra Finch
斑胸草雀宋核 HVC 的分子分析
- 批准号:
7626809 - 财政年份:2008
- 资助金额:
$ 37.15万 - 项目类别:
Cellular and Synaptic Physiology of Auditory Processing
听觉处理的细胞和突触生理学
- 批准号:
7107951 - 财政年份:2005
- 资助金额:
$ 37.15万 - 项目类别:
Cellular and Synaptic Physiology of Auditory Processing
听觉处理的细胞和突触生理学
- 批准号:
6989257 - 财政年份:2005
- 资助金额:
$ 37.15万 - 项目类别:
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