Transition Support for ZEBrA, A Gene Expression Brain Atlas of the Zebra Finch
Transition Support for ZEBrA, A Gene Expression Brain Atlas of the Zebra Finch
批准号:
9164865
负责人:
Claudio V Mello
金额:
$19.41万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-16 至 2019-08-31
关键词:
AddressAdultAffectAnimal ModelAreaAtlasesBase of the BrainBehaviorBirdsBrainCell NucleusChickensCognitionCognitiveCollectionColumbidaeCommunitiesComparative StudyComplexCountryCustomDataDatabasesDevelopmentDiseaseEnsureEvaluationEvolutionFundingFunding AgencyFutureGene ExpressionGene StructureGenesGeneticGenetic ProgrammingGoalsGonadal Steroid HormonesGrantGuineaHealthHistologyHumanImageIn SituIn Situ HybridizationIndividualInstitutesInternetInvestigationLanguageLearningLinkMaintenanceMammalsMental disordersMissionModelingMolecularMolecular ProfilingMonoclonal Antibody R24MusNational Institute of Child Health and Human DevelopmentNational Institute of General Medical SciencesNational Institute of Mental HealthNational Institute of Neurological Disorders and StrokeNational Institute on Deafness and Other Communication DisordersNeurobiologyNeuronsOperating SystemOrganismPathway interactionsPatternPhase TransitionPhenotypePhysiologyPlayPreparationProcessProcessed GenesProductionProtocols documentationQuailResearch PersonnelResolutionResourcesRodentRoleSerinusServicesSongbirdsSourceSpeechStructureStructure-Activity RelationshipSturnus vulgarisSynapsesSystemUnited States National Institutes of HealthUpdateVisitWorkadult neurogenesisbasebird songbrain healthcognitive skillcomparativecostdifferential expressiondigital imagingexperiencehuman diseaseimprovedinsightinterestlearned behaviormalemeetingsnervous system disorderneurodevelopmentneuronal excitabilityneuronal replacementnonhuman primatenovelselective expressionsexual dimorphismtooltraitusabilityvocal controlvocal learningweb sitezebra finch
中文摘要
项目总结
英文摘要
Project Summary
Avian model organisms, including songbirds (zebra finch, canaries, starlings), chicken, quail, and pigeon have
contributed much to our understanding of brain function and of disorders that affect neural development,
function, and cognition. However, we still lack a clear understanding of how avian brain structures, particularly
those that subserve complex learned behaviors and cognition, relate to brain structures in mammals, including
humans. It is also unclear how molecular brain specializations of birds relate to those of mammals. To address
these gaps, we used funding from the NINDS (R03) and NIGMS (R24) to develop the Zebra finch Brain
Expression Atlas (ZEBrA), currently the only in situ hybridization database of brain gene expression for any
avian species. ZEBrA is a publicly accessible website that contains >2,200 high resolution digital images of
brain sections from adult male zebra finches that are aligned to a reference histological atlas, and hybridized to
reveal the expression of >500 genes of relevance for brain development, physiology, plasticity, and learning,
including numerous linked to human diseases or to lethal or deleterious phenotypes in rodents. Many of the
patterns in ZEBrA reveal differential expression across broad brain subdivisions, previously unsuspected
subdomains that cannot be visualized with conventional histology, and high enrichment in nuclei within circuits
underlying specific behaviors (e.g., the system that controls vocal production and learning). These patterns
have yielded novel insights into molecular specializations of major regions and of specific nuclei, including the
discovery of convergent molecular specializations of vocal areas that are shared between songbirds and
humans. The availability of ZEBrA has had a large impact (>4,000 users, and 35,000 page views), providing an
important source of genetic and neuroanatomical data for a large number of songbird and avian researchers,
many funded by the NIDCD, NIMH, NINDS or NICHD. The present proposal aims to use NIGMS's Legacy
mechanism to maintain ZEBrA during a transition phase where further funding is sought to ensure the long-
term availability, maintenance, and possible future expansion of this unique resource. Such studies will help to
further validate the use of avian model organisms for understanding the molecular basis of brain function and
disorders. Planned activities consist of regular updates to ZEBrA to ensure links to important databases and
compatibility to browsers are kept up-to-date, and addition of 300 already processed genes whose images are
not yet available online. Included are also plans for broad dissemination of the resource, close interactions with
the community to ensure its needs are met, and evaluation to maximize ZEBrA's utility and impact. Legacy
funding will facilitate the transition effort, which includes the preparation of applications to an array of NIH
institutes whose stated missions are in line with ZEBrA's goals, and a more limited effort to generate brain
expression data for specific genes of interest to individual users but not yet on the database, on a pay for
service basis.
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Molecular profiling of the zebra finch brain
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批准号:10062755
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资助金额:$15.4万
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批准号:8245200
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资助金额:$38.5万
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批准号:8444464
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资助金额:$37.15万
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批准号:8052763
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资助金额:$38.5万
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财政年份:2010
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负责人:Claudio V Mello
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A Gene Expression Brain Atlas of the Zebra Finch.
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批准号:7873564
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项目类别:
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资助金额:$38.5万
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财政年份:2010
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负责人:Claudio V Mello
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依托单位:
Estrogens and Central Auditory Processing of Birdsong
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批准号:7599287
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项目类别:
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资助金额:$21.41万
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财政年份:2008
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负责人:Claudio V Mello
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依托单位:
Molecular Profiling of Song Nucleus HVC in the Zebra Finch
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批准号:7626809
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资助金额:$7.7万
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财政年份:2008
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负责人:Claudio V Mello
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依托单位:
Cellular and Synaptic Physiology of Auditory Processing
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批准号:7107951
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项目类别:
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资助金额:$3.44万
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财政年份:2005
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负责人:Claudio V Mello
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依托单位:
Cellular and Synaptic Physiology of Auditory Processing
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批准号:6989257
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项目类别:
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资助金额:$4.03万
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财政年份:2005
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负责人:Claudio V Mello
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依托单位:
Cellular and Synaptic Physiology of Auditory Processing
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批准号:7263981
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项目类别:
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资助金额:$3.34万
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财政年份:2005
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负责人:Claudio V Mello
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依托单位:
Gene Regulation in Auditory Learning
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批准号:6767830
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项目类别:
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资助金额:$32.03万
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财政年份:1996
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负责人:Claudio V Mello
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依托单位:
Gene Regulation in Auditory Learning
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批准号:6681528
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项目类别:
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资助金额:$33.19万
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财政年份:1996
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负责人:Claudio V Mello
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依托单位:
Gene Regulation in Auditory Learning
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批准号:7067612
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项目类别:
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资助金额:$26.84万
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财政年份:1996
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负责人:Claudio V Mello
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依托单位:
Gene Regulation in Auditory Learning
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批准号:7228575
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项目类别:
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资助金额:$26.06万
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财政年份:1996
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负责人:Claudio V Mello
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依托单位:
Gene Regulation in Auditory Learning
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批准号:6899358
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项目类别:
-
资助金额:$32.03万
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财政年份:1996
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负责人:Claudio V Mello
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依托单位:
GENE REGULATION IN AUDITORY LEARNING
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批准号:6175373
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项目类别:
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资助金额:$6.88万
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财政年份:1996
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负责人:Claudio V Mello
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依托单位:
GENE REGULATION IN AUDITORY LEARNING
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批准号:2128367
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项目类别:
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资助金额:$11.17万
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财政年份:1996
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负责人:Claudio V Mello
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依托单位:
GENE REGULATION IN AUDITORY LEARNING
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批准号:2749247
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项目类别:
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资助金额:$12.87万
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财政年份:1996
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负责人:Claudio V Mello
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依托单位:
GENE REGULATION IN AUDITORY LEARNING
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批准号:2458544
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项目类别:
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资助金额:$12.28万
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财政年份:1996
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负责人:Claudio V Mello
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依托单位:
海外基金