BIOMEDICAL ANALYSIS OF HUMAN BIOSPECIMENS FOR DIPHR
DIPHR 人体生物样本的生物医学分析
基本信息
- 批准号:8740710
- 负责人:
- 金额:$ 14.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-09 至 2014-09-08
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentAfrican AmericanAlbuminsAliquotAncillary StudyBehavioralBioinformaticsBiological MarkersBiometryBody fatBone Mineral ContentsCalciumChildChild health careChildhoodClinicContractsDual-Energy X-Ray AbsorptiometryEpidemiologic StudiesEpidemiologyHealth behaviorHumanHuman DevelopmentInfantInstitutesLaboratoriesLow Birth Weight InfantMeasuresMissionMothersNational Institute of Child Health and Human DevelopmentNeonatalNewborn InfantParticipantPerinatalPhysiologic calcificationPre-EclampsiaPregnancyPreventionPrevention ResearchProtein IsoformsRaceResearchRiskSamplingScanningSerumSeveritiesShippingShipsSiteSupplementationTask PerformancesTestingVitamin DVitamin D DeficiencyVitamin D-Binding ProteinWomandesignfetalpopulation healthrepositoryreproductive
项目摘要
The tasks to utilize this contract are to analyze samples from the Calcium for Preeclampsia
Prevention trial (CPEP) to measure total 25(0H)D, its isoforms (25(0H)D2 and 25(0H)D3),
Vitamin D binding protein (VDBP), albumin, and total calcium in up to 992 serum samples from
the CPEP trial. Period of performance for this task is estimated to be 6 months.
The Division of lntramural Population Health Research of the Eunice Kennedy Shriver National
Institute of Child Health and Human Development encompasses three branches: 1)
Epidemiology Branch; 2) Biostatistics and Bioinformatics Branch and 3) Prevention Research
Branch [http://www.nichd.nih.gov/about/org/despr/]. Central to the Division's mission is to
design, implement, and direct epidemiologic, behavioral and biostatistical research which
focuses on reproductive, perinatal and pediatric epidemiologic research as well as research
addressing child and adolescent health behaviors.
The Division previously conducted the Calcium for Preeclampsia Prevention (CPEP) trial from
1992-1995 across 5 clinics in the US testing the effect of calcium supplementation on risk and
severity of preeclampsia (PE). One of the CPEP study sites (Memphis, TN) conducted an
ancillary study of' Fetal bone mineralization' whereby both the mother and her newborn could
receive a dual-energy X-ray absorptiometry (DXA) scan. Several studies have shown that .
women with vitamin D deficiency during pregnancy tend to have infants with lower birth weight,
although the evidence is still controversial. To build on previous findings, we will measure
maternal CPEP serum samples for vitamin D biomarkers to investigate maternal vitamin D status
in association with neonatal body fat and neonatal bone mineral content. Maternal vitamin D
status will also be examined in association with maternal bone mineral content. Serum samples
collected longitudinally in this trial will offer several measures of vitamin D status throughout
gestation enabling us to better characterize the vitamin D profile of these women. These
measures will also be used to characterize the trajectories of vitamin D biomarkers across
gestation stratifying by two racial groups namely Whites and African-Americans. Serum samples
from the trial have been stored in the NICHD Bio-repository at -70¿C. Aliquots of the
participants will be shipped to the laboratory
利用该合同的任务是分析先兆子痫钙的样本
预防试验(CPEP),测量总25(OH)D及其亚型(25(OH)D2和25(OH)D3),
维生素D结合蛋白(VDBP)、白蛋白和总钙在多达992份来自
CPEP试验此任务的执行期预计为6个月。
Eunice Kennedy Shriver国家大学校内人口健康研究部
儿童健康和人类发展研究所包括三个分支机构:
流行病学分支; 2)生物统计学和生物信息学分支和3)预防研究
分支[http://www.nichd.nih.gov/about/org/despr/]。该司的核心使命是
设计、实施和指导流行病学、行为学和生物统计学研究,
侧重于生殖、围产期和儿科流行病学研究以及研究
解决儿童和青少年健康行为问题。
该司以前进行了钙预防先兆子痫(CPEP)试验,
1992-1995年,在美国5家诊所测试补钙对风险和
先兆子痫(PE)的严重程度。其中一个CPEP研究中心(孟菲斯,TN)进行了
“胎儿骨矿化”的辅助研究,母亲和新生儿都可以
接受双能X线吸收测定法(DXA)扫描。几项研究表明。
怀孕期间缺乏维生素D的妇女往往会生下体重较轻的婴儿,
尽管证据仍有争议。为了建立在以前的研究结果,我们将衡量
用于维生素D生物标志物的母体CPEP血清样本,以研究母体维生素D状态
与新生儿体脂和新生儿骨矿物质含量相关。母体维生素D
还将检查与母体骨矿物质含量相关的状态。血清样品
在这项试验中纵向收集的数据将提供几种维生素D状态的测量方法,
使我们能够更好地描述这些妇女的维生素D谱。这些
还将使用测量来表征维生素D生物标志物的轨迹,
妊娠期分为两个种族群体,即白人和非裔美国人。血清样品
已在-70 ° C下储存在NICHD生物储存库中。的等分试样
参与者将被运送到实验室
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('ERIN ALLEN', 18)}}的其他基金
EVALUATION OF THE PHARMACOKINETIC PROFILE, EFFECTS ON THE MECHANISMS
药代动力学特征的评估以及对机制的影响
- 批准号:
8755662 - 财政年份:2013
- 资助金额:
$ 14.66万 - 项目类别:
CCTN - CONTRACEPTIVE EFFICACY AND SAFETY OF DAILY ORAL ULIPRISTAL ACETATE
CCTN - 每日口服醋酸乌利司他的避孕功效和安全性
- 批准号:
8730338 - 财政年份:2013
- 资助金额:
$ 14.66万 - 项目类别:
CCTN - CONTRACEPTIVE CLINICAL TRIALS NETWORK - CORE - MALE
CCTN - 避孕临床试验网络 - 核心 - 男性
- 批准号:
8749805 - 财政年份:2013
- 资助金额:
$ 14.66万 - 项目类别:
CCTN - EVALUATION OF THE PHARMACOKINETIC PROFILE, EFFECTS ON THE MECHANISMS
CCTN - 药代动力学特征的评估,对机制的影响
- 批准号:
10923774 - 财政年份:2013
- 资助金额:
$ 14.66万 - 项目类别:
CCTN - CONTRACEPTIVE EFFICACY AND SAFETY OF DAILY ORAL ULIPRISTAL ACETATE
CCTN - 每日口服醋酸乌利司他的避孕功效和安全性
- 批准号:
10078224 - 财政年份:2013
- 资助金额:
$ 14.66万 - 项目类别:
CCTN - EVALUATION OF THE PHARMACOKINETIC PROFILE, EFFECTS ON THE MECHANISMS
CCTN - 药代动力学特征的评估,对机制的影响
- 批准号:
10710521 - 财政年份:2013
- 资助金额:
$ 14.66万 - 项目类别:
MATERNAL VITAMIN D STATUS AND MEASURES OF NEONATAL BONE MINERAL CONT
母体维生素 D 状况和新生儿骨矿物质含量测量
- 批准号:
8749653 - 财政年份:2013
- 资助金额:
$ 14.66万 - 项目类别:
CCTN - CONTRACEPTIVE EFFICACY AND SAFETY OF DAILY ORAL ULIPRISTAL ACETATE
CCTN - 每日口服醋酸乌利司他的避孕功效和安全性
- 批准号:
8744409 - 财政年份:2013
- 资助金额:
$ 14.66万 - 项目类别:
CCTN - EVALUATION OF THE PHARMACOKINETIC PROFILE, EFFECTS ON THE MECHANISMS
CCTN - 药代动力学特征的评估,对机制的影响
- 批准号:
9915804 - 财政年份:2013
- 资助金额:
$ 14.66万 - 项目类别:
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