BIOMEDICAL ANALYSIS OF HUMAN BIOSPECIMENS FOR DIPHR

DIPHR 人体生物样本的生物医学分析

• 批准号: 8740710
• 负责人: ERIN ALLEN
• 金额: $ 14.66万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-09 至 2014-09-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8740710
• 关键词: Address; Adolescent; African American; Albumins; Aliquot; Ancillary Study; Behavioral; Bioinformatics; Biological Markers; Biometry; Body fat; Bone Mineral Contents; Calcium; Child; Child health care; Childhood; Clinic; Contracts; Dual-Energy X-Ray Absorptiometry; Epidemiologic Studies; Epidemiology; Health behavior; Human; Human Development; Infant; Institutes; Laboratories; Low Birth Weight Infant; Measures; Mission; Mothers; National Institute of Child Health and Human Development; Neonatal; Newborn Infant; Participant; Perinatal; Physiologic calcification; Pre-Eclampsia; Pregnancy; Prevention; Prevention Research; Protein Isoforms; Race; Research; Risk; Sampling; Scanning; Serum; Severities; Shipping; Ships; Site; Supplementation; Task Performances; Testing; Vitamin D; Vitamin D Deficiency; Vitamin D-Binding Protein; Woman; design; fetal; population health; repository; reproductive

The tasks to utilize this contract are to analyze samples from the Calcium for Preeclampsia Prevention trial (CPEP) to measure total 25(0H)D, its isoforms (25(0H)D2 and 25(0H)D3), Vitamin D binding protein (VDBP), albumin, and total calcium in up to 992 serum samples from the CPEP trial. Period of performance for this task is estimated to be 6 months. The Division of lntramural Population Health Research of the Eunice Kennedy Shriver National Institute of Child Health and Human Development encompasses three branches: 1) Epidemiology Branch; 2) Biostatistics and Bioinformatics Branch and 3) Prevention Research Branch [http://www.nichd.nih.gov/about/org/despr/]. Central to the Division's mission is to design, implement, and direct epidemiologic, behavioral and biostatistical research which focuses on reproductive, perinatal and pediatric epidemiologic research as well as research addressing child and adolescent health behaviors. The Division previously conducted the Calcium for Preeclampsia Prevention (CPEP) trial from 1992-1995 across 5 clinics in the US testing the effect of calcium supplementation on risk and severity of preeclampsia (PE). One of the CPEP study sites (Memphis, TN) conducted an ancillary study of' Fetal bone mineralization' whereby both the mother and her newborn could receive a dual-energy X-ray absorptiometry (DXA) scan. Several studies have shown that . women with vitamin D deficiency during pregnancy tend to have infants with lower birth weight, although the evidence is still controversial. To build on previous findings, we will measure maternal CPEP serum samples for vitamin D biomarkers to investigate maternal vitamin D status in association with neonatal body fat and neonatal bone mineral content. Maternal vitamin D status will also be examined in association with maternal bone mineral content. Serum samples collected longitudinally in this trial will offer several measures of vitamin D status throughout gestation enabling us to better characterize the vitamin D profile of these women. These measures will also be used to characterize the trajectories of vitamin D biomarkers across gestation stratifying by two racial groups namely Whites and African-Americans. Serum samples from the trial have been stored in the NICHD Bio-repository at -70¿C. Aliquots of the participants will be shipped to the laboratory

使用该合同的任务是分析钙的样本 预防试验（CPEP）测量总计25（0H）D，其同工型（25（0H）D2和25（0H）D3）， 维生素D结合蛋白（VDBP），白蛋白和总钙在多达992种血清样品中 CPEP试验。该任务的绩效期限估计为6个月。 Eunice Kennedy Shriver National的Lntramural人口健康研究部 儿童健康与人类发展研究所包括三个分支：1） 流行病学分支； 2）生物统计学和生物信息学分支机构和3）预防研究 分支[http://www.nichd.nih.gov/about/org/despr/]。该部门任务的中心是 设计，实施以及直接流行病学，行为和生物统计研究，这些研究 专注于生殖，围产期和小儿流行病学研究以及研究 解决儿童和青少年健康行为。 该部门先前从事预防钙预防钙（CPEP）试验 1992 - 1995年在美国5个诊所中 子痫前期（PE）的严重程度。 CPEP研究地点之一（孟菲斯，田纳西州）进行了 “胎儿骨矿化”的辅助研究，母亲和她的新生儿都可以 接受双能X射线绝对肽（DXA）扫描。几项研究表明。 怀孕期间维生素D缺乏症的妇女往往患有较低的出生体重， 尽管证据仍然存在争议。为基于以前的发现，我们将衡量 维生素D生物标志物研究母体维生素D状态的母体CPEP血清样品 与新生儿体内脂肪和新生儿骨矿物质含量有关。母体维生素d 还将与Mater骨矿物质含量有关检查状态。血清样品 在此试验中纵向收集将提供多种维生素D状态的措施 妊娠使我们能够更好地表征这些女性的维生素D特征。这些 措施也将用于表征跨维生素D生物标志物的轨迹 两个种族群体（即白人和非裔美国人）进行妊娠分层。血清样品 从试验中存储在-70�的NICHD生物re命名中。 参与者将被运送到实验室