Hair cortisol as a biomarker of chronic stress in mother-infant dyads

头发皮质醇作为母婴二人慢性压力的生物标志物

• 批准号: 8448073
• 负责人: CINDY H LIU
• 金额: $ 18.09万
• 依托单位: UNIVERSITY OF MASSACHUSETTS BOSTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8448073
• 关键词: Adult; Adverse effects; Anxiety; Behavioral; Biological; Biological Assay; Biological Markers; Birth; Blood; Calendar; Chronic; Chronic stress; Data; Development; Ethnic Origin; Exhibits; Future; Goals; Hair; Hydrocortisone; Infant; Infant Development; Intervention; Interview; Knowledge; Measurement; Measures; Mental Depression; Methods; Mood Disorders; Mothers; Participant; Patient Self-Report; Pattern; Physiological; Population; Postpartum Period; Problem behavior; Procedures; Questionnaires; Race; Recruitment Activity; Reporting; Research Personnel; Risk; Saliva; Sampling; Socioeconomic Status; Source; Stress; Structure; Symptoms; System; Time; Trauma; Urine; Visit; Woman; adverse outcome; base; cohort; experience; falls; high risk; high risk infant; infant monitoring; interest; longitudinal design; psychological outcomes; socioeconomics; stress related disorder; tool

DESCRIPTION (provided by applicant): The purpose of this study is to better understand the effects of chronic stress on mothers and their infants. Women are prone to chronic stress and stress-related disorders (e.g., depression, anxiety) within the first year of giving birth, and thee maternal experiences are known to have an adverse effect on infants' development including the organization of their HPA axis and other stress related systems. Unfortunately,, not only are there few studies pertaining to the effects of chronic stress on mothers and infants, but the measurement of chronic stress in any population is problematic. Assessing chronic stress is particularly difficult in populations such as infants, since subjective report from others falls shrt of identifying the infants' experience. Biological measures of chronic stress often rely on measures of basal levels of cortisol. However, it is quite possible that assessments of cortisol from saliva, blood, and urine and the requirement with these measures to capture multiple time points do not adequately capture the chronic levels of stress that they purport to measure. The goal of this project is to evaluate the use of hair cortisol as a biomarker for chronic stress in mother-infant dyads. Hair cortisol is an emerging biomarker that may be an effective method for measuring HPA activity, as it can provide a longer retrospective calendar (e.g., 3- to 6-months) of chronic stress compared with measures of cortisol from other sources. From a practical standpoint, the sampling and storage of hair cortisol may be less cumbersome than the current procedures required from cortisol collected from saliva, blood, or urine. Hair cortisol may provide an effective marker for such stress related disorders and be an important tool for determining risk of later developmental problems among infants. To accomplish our goal, we will use a longitudinal design that follows two cohorts "high risk" (n=80) and "low risk" (n=80) mother-infant dyads at 9 months (T1) and 12 months (T2) postpartum. By using up-to-date hair cortisol sampling and assay procedures, we expect that the hair sampled from mothers and infants at these time points will provide retrospective cortisol data from the previous 3 months (T1: 6-9 months, T2: 9-12 months). Reported chronic stress, depression and anxiety symptoms, and trauma exposure will also be collected from the mother through questionnaires and interviews. We plan to calculate differences in hair cortisol across groups, associations between mother and infant hair cortisol, and associations of hair cortisol levels with reported chronic stress. We expect the "high risk" group to have higher levels of cortisol than the "low risk" group, positive associations of the hair cortisol levels of mothers and infants, and positive associations of the hair cortisol and reported chronic stress. Because hair cortisol is a new measure and has never been used with mother-infant dyads, we will track participant recruitment rates. This project has the potential to establish a useful and efficient biomarker for chronic stress while propelling our understanding of the mechanisms (factors and moderators) that underlie chronic stress and adverse outcomes in mothers and infants.

描述（由申请人提供）：本研究的目的是更好地了解慢性压力对母亲及其婴儿的影响。妇女容易在分娩的第一年内患慢性压力和与压力有关的疾病（例如抑郁，焦虑），而众所周知，孕产妇经历对婴儿的发育有不利影响，包括其HPA轴和其他与压力相关的系统的组织。不幸的是，不仅很少有与慢性应激对母亲和婴儿的影响有关的研究，而且在任何人群中慢性压力的测量都是有问题的。在婴儿等人群中，评估慢性压力尤其困难，因为其他人的主观报告落在了识别婴儿的经历方面。慢性应激的生物学测量通常取决于皮质醇基础水平的度量。但是，很有可能对唾液，血液和尿液的皮质醇进行评估，并且这些措施捕获多个时间点的要求并不能充分捕获他们所主张的测量的慢性压力水平。该项目的目的是评估母蛋白蛋白质素作为母性二元组中慢性压力的生物标志物的使用。皮质醇是一种新兴的生物标志物，可能是测量HPA活性的有效方法，因为与其他来源的皮质醇测量相比，它可以提供更长的回顾性日历（例如3至6个月）的慢性应激。从实际的角度来看，皮质醇的采样和储存可能比从唾液，血液或尿液中收集的皮质醇所需的当前程序繁琐。皮质醇可能会提供 这是这种与压力相关疾病的有效标记，并且是确定婴儿以后发育问题风险的重要工具。为了实现我们的目标，我们将使用纵向设计，该设计遵循两个队列的“高风险”（n = 80）和“低风险”（n = 80）（n = 80） 9个月（T1）和12个月（T2）产后的二元组。通过使用最新的头发皮质醇采样和测定程序，我们预计在这些时间点，从母亲和婴儿中取样的头发将提供前3个月的回顾性皮质醇数据（T1：6-9个月，T2：9-12个月）。报告的慢性压力，抑郁症和焦虑症状以及外伤还将通过问卷调查和访谈从母亲那里收集。我们计划计算跨组的头发皮质醇的差异，母亲和婴儿头发皮质醇之间的关联，以及毛皮质醇水平与报告的慢性胁迫的关联。我们 预计“高风险”组的皮质醇水平要高于“低风险”群体，母亲和婴儿的皮质醇水平的正相关，以及毛皮质醇的正相关并报告的慢性压力。由于头发皮质醇是一种新措施，并且从未与母亲二元组一起使用，因此我们将跟踪参与者的招聘率。该项目有可能为慢性压力建立有用且有效的生物标志物，同时推动我们 了解母亲和婴儿的慢性压力和不良后果的机制（因素和主持人）。