Maternal psychosis and stress as risks for offspring behavioral impairment

项目摘要/摘要-未更改上级拨款 该项目旨在改善患有精神病的妇女及其子女的生活，这是一个被忽视的问题 人口，尽管这些妇女在围产期经历了压力和逆境，而且 记录了他们的孩子在各种行为和认知方面的生物和心理社会风险 有问题。有希望的是通过以下方式潜在地识别这些损害的早期迹象 早在怀孕的时候就研究母亲和后代。此K奖申请旨在为刘欣迪博士做好准备 成为一名独立的临床研究人员，并在妇女面临的许多问题上发展专业知识 患有精神病及其家人；具体地说，是关于母亲应激经历后果的专业知识 以及最终开发干预措施以缓解压力及其脱轨后果的能力 孩子们。为了实现这一目标，拟议的研究战略在该领域内的两个高度相关的领域之间架起了桥梁： 精神病的常见高危(HR)研究和发育早期基于生物学的应激模型 科学通过两项互补的研究。通过研究一、二次数据分析对某大型 纵向出生队列数据集、早期生物和环境风险以及早期行为损害 从出生到7岁将在患有精神病的父母(n=208)和配对的父母的子女中确定 对照组(n=132)。在研究2中，刘博士将确定不良后果的行为和生理标志 一个新的精神病儿童及其母亲样本(n=25)，以及匹配的对照组母亲 有非精神病性情绪障碍的母亲(n=25)，并通过以下方式控制母亲(n=25) 初步数据收集，通过评估母亲和儿童的行为和生理反应 怀孕至产后4个月。这两项研究为研究产前应激提供了机会。 在不同的时间范围内，并利用发育适当的生物和行为措施 对这群人的压力。这样做可能会回答有关导致发育迟缓的机制的问题 并将使刘博士做好准备，制定一份R01提案，说明如何 围产期应激经历会影响4岁高危儿童的社会情绪发育。 总而言之，即将实施的培训计划将支持刘博士向独立的过渡。两个人 研究将提供一系列针对压力作用的从宏观到微观的独特技能发展 高危儿童在特定发育时间点的行为和生理反应。此外， 通过早期的生物和行为模型评估风险纵向轨迹的项目重点 压力促进了NIMH在发展性翻译研究中的优先地位。它将使一个有意义的 有助于了解精神疾病的发展和提供有针对性的预防 以及对受精神病影响的家庭进行治疗干预。

Project Summary/Abstract - Unchanged from parent grant This project is designed to improve the lives of women with psychosis and their children, an ”ignored” population, despite the stress and adversity experienced by these women during the perinatal period, and the documented biological and psychosocial risks on their children for a wide range of behavioral and cognitive problems. What is promising are the ways to potentially identify the early signs for these impairments by studying mothers and offspring as early as pregnancy. This K-award application aims to prepare Dr. Cindy Liu to become an independent clinical researcher and to develop expertise in many of the issues that face women with psychosis and their families; specifically, expertise in the consequences of maternal stress experiences and the ability to ultimately develop interventions that ameliorate stress and its derailing consequences for children. To accomplish this, the proposed research strategy bridges two highly relevant areas within the field: familiar high-risk (HR) research in psychosis and biologically based early stress models from developmental science through complementary two studies. Through Study 1, a secondary data analysis of a large longitudinal birth cohort dataset, early biological and environmental risks and early behavioral impairments from birth to age 7 years will be identified in offspring of parents with psychosis (n=208) and in matched controls (n=132). In Study 2, Dr. Liu will identify behavioral and physiological markers of adverse outcomes in a new sample of children and their mothers with psychosis (n=25), and matched comparison groups, mothers with non-psychotic mood disorders (n=25), and control mothers without psychiatric disorders (n=25) through primary data collection, by assessing behavioral and physiological responses in mothers and children from pregnancy until 4 months postpartum. These two studies provide the opportunity to investigate prenatal stress across different time frames and to utilize developmentally appropriate biological and behavioral measures of stress with this population. Doing so may answer questions about the mechanisms leading to developmental impairments in these high-risk children and will prepare Dr. Liu to develop a R01 proposal that informs how perinatal stress experiences affect socio-emotional development in high-risk children at 4 years of age. In summary, the training plan to be implemented will support Dr. Liu's transition to independence. The two studies will provide a range of unique macro to micro skill development that targets the role of stress on behavioral and physiological reactivity in high-risk children at specific developmental time points. Moreover, the project focus of assessing longitudinal trajectories for risk through a biological and behavioral model of early stress advances the NIMH priority for developmental translational research. It is poised to make a meaningful contribution toward understanding the development of psychiatric conditions and to inform targeted prevention and treatment interventions for families affected by psychosis.