Maternal psychosis and stress as risks for offspring behavioral impairment

项目概要/摘要-与母公司赠款保持不变 该项目旨在改善患有精神病的妇女及其子女的生活， 尽管这些妇女在围产期经历了压力和逆境， 有记录的生物和心理社会风险对他们的孩子的广泛的行为和认知 问题有希望的是通过以下方式潜在地识别这些损伤的早期迹象的方法 研究母亲和孩子在怀孕初期的情况。本次K奖申请旨在帮助刘欣博士 成为一名独立的临床研究人员，并在妇女面临的许多问题上发展专业知识， 精神病及其家庭;特别是，在产妇压力经历的后果的专业知识 以及最终开发干预措施的能力，这些干预措施可以减轻压力及其对 孩子为了实现这一目标，拟议的研究战略将该领域内两个高度相关的领域联系起来： 熟悉的精神病高风险（HR）研究和基于生物学的早期应激模型， 通过两项研究互补的科学。通过研究1，一个大型的二级数据分析， 纵向出生队列数据集，早期生物和环境风险以及早期行为障碍 从出生到7岁，将在患有精神病的父母的后代（n = 208）和匹配的 对照组（n = 132）。在研究2中，刘博士将确定不良结局的行为和生理标志物， 一个新的样本的儿童和他们的母亲与精神病（n = 25），和匹配的对照组，母亲 患有非精神病性情绪障碍的母亲（n = 25），以及没有精神疾病的对照母亲（n = 25） 主要数据收集，通过评估母亲和儿童的行为和生理反应， 怀孕至产后4个月。这两项研究提供了调查产前压力的机会 在不同的时间框架，并利用发育适当的生物和行为措施， 对这个人群的压力。这样做可能会回答有关导致发展的机制的问题。 这些高危儿童的障碍，并将准备刘博士制定一个R01的建议，告知如何 围产期的紧张经历影响到4岁高危儿童的社会情感发展。 总之，即将实施的培训计划将支持刘博士向独立过渡。两 研究将提供一系列独特的宏观到微观技能发展，目标是强调 高危儿童在特定发育时间点的行为和生理反应。而且 项目重点是通过早期生物和行为模型评估风险的纵向轨迹， 压力推进了NIMH优先发展转化研究。它准备做出一个有意义的 有助于了解精神疾病的发展并为有针对性的预防提供信息 和治疗干预受精神病影响的家庭。

Project Summary/Abstract - Unchanged from parent grant This project is designed to improve the lives of women with psychosis and their children, an ”ignored” population, despite the stress and adversity experienced by these women during the perinatal period, and the documented biological and psychosocial risks on their children for a wide range of behavioral and cognitive problems. What is promising are the ways to potentially identify the early signs for these impairments by studying mothers and offspring as early as pregnancy. This K-award application aims to prepare Dr. Cindy Liu to become an independent clinical researcher and to develop expertise in many of the issues that face women with psychosis and their families; specifically, expertise in the consequences of maternal stress experiences and the ability to ultimately develop interventions that ameliorate stress and its derailing consequences for children. To accomplish this, the proposed research strategy bridges two highly relevant areas within the field: familiar high-risk (HR) research in psychosis and biologically based early stress models from developmental science through complementary two studies. Through Study 1, a secondary data analysis of a large longitudinal birth cohort dataset, early biological and environmental risks and early behavioral impairments from birth to age 7 years will be identified in offspring of parents with psychosis (n=208) and in matched controls (n=132). In Study 2, Dr. Liu will identify behavioral and physiological markers of adverse outcomes in a new sample of children and their mothers with psychosis (n=25), and matched comparison groups, mothers with non-psychotic mood disorders (n=25), and control mothers without psychiatric disorders (n=25) through primary data collection, by assessing behavioral and physiological responses in mothers and children from pregnancy until 4 months postpartum. These two studies provide the opportunity to investigate prenatal stress across different time frames and to utilize developmentally appropriate biological and behavioral measures of stress with this population. Doing so may answer questions about the mechanisms leading to developmental impairments in these high-risk children and will prepare Dr. Liu to develop a R01 proposal that informs how perinatal stress experiences affect socio-emotional development in high-risk children at 4 years of age. In summary, the training plan to be implemented will support Dr. Liu's transition to independence. The two studies will provide a range of unique macro to micro skill development that targets the role of stress on behavioral and physiological reactivity in high-risk children at specific developmental time points. Moreover, the project focus of assessing longitudinal trajectories for risk through a biological and behavioral model of early stress advances the NIMH priority for developmental translational research. It is poised to make a meaningful contribution toward understanding the development of psychiatric conditions and to inform targeted prevention and treatment interventions for families affected by psychosis.