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Maternal psychosis and stress as risks for offspring behavioral impairment

母亲精神病和压力是后代行为障碍的风险

基本信息

批准号：
10209406
负责人：
CINDY H LIU
金额：
$ 5.4万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-04 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10209406
关键词：
4 year old 7 year old Address Adolescence Adopted Affect Age-Months Apgar Score Area Autonomic nervous system Behavioral Behavioral Model Biological Biological Models Birth Case-Control Studies Child Child Rearing Childhood Clinical Clinical Research Cognitive Communities Complex Data Data Analyses Data Collection Data Set Development Disease Early Intervention Emotional Environment Environmental Risk Factor Equilibrium Event Exposure to Face Family Family Study Genetic Goals Hair Healthcare Heart Rate Hydrocortisone Hypoxia Impairment Infant Infant Behavior Infant Development Infection Intervention Intervention Studies K-Series Research Career Programs Knowledge Lead Life Life Stress Maternal and Child Health Measures Mental disorders Modeling Moods Mothers National Institute of Mental Health Neurologic New England Newborn Infant Outcome Parents Patient Self-Report Perinatal Perinatal Exposure Phase Physiological Physiology Plant Roots Play Population Population Study Postpartum Period Poverty Pre-Eclampsia Pregnancy Pregnant Women Prevention Preventive Intervention Principal Investigator Psychosocial Stress Psychotic Disorders Readiness Research Research Personnel Risk Risk Factors Role Running Salivary Sampling Schizophrenia Schools Science Second Pregnancy Trimester Stress System Third Pregnancy Trimester Time Training Translational Research Woman adverse outcome affective psychoses base behavior measurement behavioral impairment behavioral outcome career case control cohort comparison group design developmental neurobiology disability early life stress emerging adult experience fetal heart rate variability high risk high risk population hypothalamic-pituitary-adrenal axis improved infancy intergenerational longitudinal analysis maternal anxiety maternal depression maternal stress neurobehavior neurobehavioral nutrition obstetrical complication offspring parent grant perinatal period prenatal prenatal experience prenatal exposure prenatal stress prevent prospective psychobiologic psychosocial response secondary analysis skill acquisition skills social stressor therapy development transmission process

项目摘要

Project Summary/Abstract - Unchanged from parent grant This project is designed to improve the lives of women with psychosis and their children, an ”ignored” population, despite the stress and adversity experienced by these women during the perinatal period, and the documented biological and psychosocial risks on their children for a wide range of behavioral and cognitive problems. What is promising are the ways to potentially identify the early signs for these impairments by studying mothers and offspring as early as pregnancy. This K-award application aims to prepare Dr. Cindy Liu to become an independent clinical researcher and to develop expertise in many of the issues that face women with psychosis and their families; specifically, expertise in the consequences of maternal stress experiences and the ability to ultimately develop interventions that ameliorate stress and its derailing consequences for children. To accomplish this, the proposed research strategy bridges two highly relevant areas within the field: familiar high-risk (HR) research in psychosis and biologically based early stress models from developmental science through complementary two studies. Through Study 1, a secondary data analysis of a large longitudinal birth cohort dataset, early biological and environmental risks and early behavioral impairments from birth to age 7 years will be identified in offspring of parents with psychosis (n=208) and in matched controls (n=132). In Study 2, Dr. Liu will identify behavioral and physiological markers of adverse outcomes in a new sample of children and their mothers with psychosis (n=25), and matched comparison groups, mothers with non-psychotic mood disorders (n=25), and control mothers without psychiatric disorders (n=25) through primary data collection, by assessing behavioral and physiological responses in mothers and children from pregnancy until 4 months postpartum. These two studies provide the opportunity to investigate prenatal stress across different time frames and to utilize developmentally appropriate biological and behavioral measures of stress with this population. Doing so may answer questions about the mechanisms leading to developmental impairments in these high-risk children and will prepare Dr. Liu to develop a R01 proposal that informs how perinatal stress experiences affect socio-emotional development in high-risk children at 4 years of age. In summary, the training plan to be implemented will support Dr. Liu's transition to independence. The two studies will provide a range of unique macro to micro skill development that targets the role of stress on behavioral and physiological reactivity in high-risk children at specific developmental time points. Moreover, the project focus of assessing longitudinal trajectories for risk through a biological and behavioral model of early stress advances the NIMH priority for developmental translational research. It is poised to make a meaningful contribution toward understanding the development of psychiatric conditions and to inform targeted prevention and treatment interventions for families affected by psychosis.

项目摘要/摘要-与父母资助相同