Maternal Psychosis and Stress as Risks for Offspring Behavioral Impairment

母亲精神病和压力是后代行为障碍的风险

• 批准号: 9180036
• 负责人: CINDY H LIU
• 金额: $ 16.97万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-04 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9180036
• 关键词: 4 year old; 7 year old; Accounting; Address; Adolescence; Adopted; Affect; Age-Months; Apgar Score; Area; Autonomic nervous system; Behavioral; Behavioral Model; Biological; Biological Models; Birth; Case-Control Studies; Child; Child Rearing; Childhood; Clinical; Clinical Research; Cognitive; Communities; Complex; Data; Data Analyses; Data Collection; Data Set; Development; Discipline of obstetrics; Disease; Emotional; Environment; Environmental Risk Factor; Equilibrium; Event; Exposure to; Face; Family; Family Study; Genetic; Goals; Hair; Healthcare; Heart Rate; Hydrocortisone; Hypoxia; Impairment; Infant; Infant Behavior; Infant Development; Infection; Intervention; Intervention Studies; K-Series Research Career Programs; Knowledge; Lead; Life; Life Stress; Maternal and Child Health; Measures; Mental disorders; Modeling; Mood Disorders; Moods; Mothers; National Institute of Mental Health; Neurologic; New England; Newborn Infant; Outcome; Parents; Patient Self-Report; Perinatal; Perinatal Exposure; Phase; Physiological; Physiology; Plant Roots; Play; Population; Postpartum Period; Poverty; Pre-Eclampsia; Pregnancy; Pregnant Women; Prevention; Preventive Intervention; Principal Investigator; Psychosocial Stress; Psychotic Disorders; Readiness; Research; Research Personnel; Risk; Risk Factors; Role; Running; Salivary; Sampling; Schizophrenia; Schools; Science; Skills Development; Stress; System; Time; Training; Translational Research; Woman; abstracting; adverse outcome; affective psychoses; base; behavior measurement; behavioral impairment; behavioral outcome; career; case control; cohort; comparison group; design; developmental neurobiology; disability; emerging adult; experience; fetal; heart rate variability; high risk; hypothalamic-pituitary-adrenal axis; improved; infancy; intergenerational; longitudinal analysis; maternal anxiety; maternal depression; maternal stress; neurobehavior; neurobehavioral; nutrition; offspring; population based; prenatal; prenatal experience; prenatal exposure; prenatal stress; prevent; prospective; psychobiologic; psychosocial; response; skill acquisition; skills; social; stressor; therapy development; transmission process

Project Summary/Abstract This project is designed to improve the lives of women with psychosis and their children, an ”ignored” population, despite the stress and adversity experienced by these women during the perinatal period, and the documented biological and psychosocial risks on their children for a wide range of behavioral and cognitive problems. What is promising are the ways to potentially identify the early signs for these impairments by studying mothers and offspring as early as pregnancy. This K-award application aims to prepare Dr. Cindy Liu to become an independent clinical researcher and to develop expertise in many of the issues that face women with psychosis and their families; specifically, expertise in the consequences of maternal stress experiences and the ability to ultimately develop interventions that ameliorate stress and its derailing consequences for children. To accomplish this, the proposed research strategy bridges two highly relevant areas within the field: familiar high-risk (HR) research in psychosis and biologically based early stress models from developmental science through complementary two studies. Through Study 1, a secondary data analysis of a large longitudinal birth cohort dataset, early biological and environmental risks and early behavioral impairments from birth to age 7 years will be identified in offspring of parents with psychosis (n=208) and in matched controls (n=132). In Study 2, Dr. Liu will identify behavioral and physiological markers of adverse outcomes in a new sample of children and their mothers with psychosis (n=25), and matched comparison groups, mothers with non-psychotic mood disorders (n=25), and control mothers without psychiatric disorders (n=25) through primary data collection, by assessing behavioral and physiological responses in mothers and children from pregnancy until 4 months postpartum. These two studies provide the opportunity to investigate prenatal stress across different time frames and to utilize developmentally appropriate biological and behavioral measures of stress with this population. Doing so may answer questions about the mechanisms leading to developmental impairments in these high-risk children and will prepare Dr. Liu to develop a R01 proposal that informs how perinatal stress experiences affect socio-emotional development in high-risk children at 4 years of age. In summary, the training plan to be implemented will support Dr. Liu's transition to independence. The two studies will provide a range of unique macro to micro skill development that targets the role of stress on behavioral and physiological reactivity in high-risk children at specific developmental time points. Moreover, the project focus of assessing longitudinal trajectories for risk through a biological and behavioral model of early stress advances the NIMH priority for developmental translational research. It is poised to make a meaningful contribution toward understanding the development of psychiatric conditions and to inform targeted prevention and treatment interventions for families affected by psychosis.

项目摘要/摘要 该项目旨在改善精神病及其子女的生活，这是一个“忽略” 人口，使命，这些妇女在围产期期间经历的压力和冒险， 对孩子的生物学和社会心理风险有记录的行为和认知范围 问题。承诺的方法是潜在地识别这些障碍的早期迹象的方法 早在怀孕就研究母亲和后代。这个K-award申请旨在准备Cindy Liu博士 成为一名独立的临床研究人员，并在面对女性的许多问题上发展专业知识 有精神病及其家人；具体而言，对母校压力体验的后果的专业知识 以及最终制定干预措施的能力，以减轻压力及其对脱轨的后果 孩子们。为此，拟议的研究策略桥接了该领域的两个高度相关领域： 熟悉的精神病和生物学上基于生物学的早期压力模型的高风险（HR）研究 通过完成两项研究科学。通过研究1，大型数据分析 纵向出生队列数据集，早期生物学和环境风险以及早期行为障碍 从出生到7岁，将在精神病的父母（n = 208）和匹配中确定 控件（n = 132）。在研究2中，刘博士将确定不良后果的行为和身体标记 一个新的儿童及其母亲患有精神病的样本（n = 25），并匹配比较组，母亲 患有非精神病情绪障碍（n = 25），以及没有精神疾病的对照母亲（n = 25） 主要数据收集，通过评估母亲和儿童的行为和身体反应 怀孕直到产后4个月。这两项研究提供了调查产前压力的机会 在不同的时间范围内，并利用开发的适当的生物学和行为度量 压力这一人群。这样做可能会回答有关导致发展的机制的问题 这些高风险儿童的损害，并将准备刘博士制定R01提案，以告知如何 围产期压力经历会影响4岁高风险儿童的社会情感发展。 总之，要实施的培训计划将支持刘博士向独立的过渡。两个 研究将为微技能开发提供一系列独特的宏观发展，以压力对压力的作用 在特定的发育时间点，高风险儿童的行为和身体反应性。而且， 通过早期的生物学和行为模型评估纵向轨迹的项目重点 压力提高了发展转化研究的NIMH优先级。有意义的 为理解精神病的发展并为有针对性的预防提供贡献 以及针对受精神病影响的家庭的治疗干预措施。