突触的遗传学研究-猫眼课题宝

突触的遗传学研究

批准号：

8461652

负责人：

LILY Y JAN

金额：

$36.44万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

依托单位国家：

美国

项目类别：

财政年份：

2001

资助国家：

美国

项目状态：

已结题

起止时间：

2001-09-01 至 2016-04-30

来源：

https://reporter.nih.gov/project-details/8461652

关键词：

1-Phosphatidylinositol 3-Kinase Action Potentials Adopted Ankyrins Area Autistic Disorder Award Axon Binding Binding Proteins Brain COX7A2L Protein Calcium Calcium Spikes Cell membrane Chloride Channels Convulsions Coupling Dendrites Distal Endoplasmic Reticulum Epilepsy Family Feedback Fluorescence Freedom Generations Genes Genetic Genetic Translation Glutamate Receptor Goals Golgi Apparatus Grant Growth Hippocampus (Brain)Inherited Instruction Ion Channel KRP protein Kinesin Kinetics Learning Legal patent Mammalian Cell Mediating Membrane Membrane Potentials Mental Retardation Mental disorders Messenger RNA Microtubule Bundle Microtubule-Associated Proteins Microtubules Modeling Motor Movement Mutant Strains Mice Mutation Myokymia N-Methyl-D-Aspartate Receptors N-Methylaspartate Neonatal Neurons Paper Phosphotransferases Physiological Plants Plus End of the Microtubule Positioning Attribute Potassium Potassium Channel Property Protein Binding Proteins Publications Publishing Regulation Reporter Research Design Research Peer Review Risk Role Signal Pathway Signal Transduction Sirolimus Site Structure Suppressor Mutations Surface Synapses Synaptic Potentials Synaptic plasticity TSC1 gene TSC2 gene Testing Translations Tuberous Sclerosis Tuberous sclerosis protein complex Varicosity Vesicle Voltage-Gated Potassium Channel Xenopus oocyte Yeasts base density dimer experience expression cloning follow-up genetic regulatory protein information processing inhibitor/antagonist insight mTOR protein meetings mutant neuronal excitability novel response sensor synaptic function synaptic inhibition trafficking voltage

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英文摘要

The long-term objectives are to study how potasslunn channels regulation contributes to neuronal signaling. The specific aims are to understand how the dendritic voltage-gated potassium channels and G proteinactivated inwardly rectifying potassium (GIRK) channels are regulated in hippocampal neurons, and how these potassium channels contribute to neuronal signaling and synaptic plasticity. The research design involves examination of mutant mice with altered or deleted potassium channel regulatory proteins, for regulation of either the local synthesis of channels in the dendrite or the activity or kinetic properties of the channel on the cell membrane. Because the Kv1 voltage-gated potassium channels reside on both dendrites and axons, the mosaic analysis with double markers (MADM) approach will be employed to study the physiological role of dendritic Kv1 channels.

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