New Biospecimens to Enhance Research in the California Teachers Study Cohort

描述（由申请人提供）：前瞻性癌症流行病学队列（CEC）可以同时研究基因、生物标志物、环境和生活方式如何共同影响癌症发病率、死亡率和临床结局。加州未来教师研究（CTS）始于1995年，当时133 479名女性公立学校专业人员完成了一份自填问卷。此后，参与者又完成了三份关于生活方式和环境暴露的问卷。CTS数据定期与加州数据库链接，以确定基本上所有的癌症、住院和死亡事件。迄今为止，CTS参与者已在目标项目中捐赠了5，428份血液和7，549份唾液样本。使遗传、分子和环境预测因子的病因学、临床和转化研究更加广泛 癌症发病率，死亡率和结果，该项目将从27，625名以前没有捐赠过生物标本的CTS参与者中收集诊断前生物标本。具体目标是收集、处理和储存1）静脉血或唾液样本和2）来自年龄<70岁且居住在加州的参与者的过夜尿液样本。来自三个CTS中心（City of Hope、加州癌症预防研究所和加州大学欧文分校）的经验丰富的现场工作人员协调小组将亲自访问参与者，并使用经过验证的标准化方案收集、处理和储存生物标本。将这一大组诊断前生物样本添加到广泛的现有和未来CTS风险因素、癌症、住院和死亡率数据中，将直接促进CTS和已建立的大型联盟中的众多高影响力研究项目。这是收集新生物样本的最佳时间，因为这些参与者将很快达到癌症发病率高峰的年龄组。将自1995年以来CTS收集的广泛暴露和生活方式数据与血液，尿液和唾液中的遗传，表观遗传和其他生物标志物相结合，将直接促进未来对基因-环境相互作用，自然史和进展，早期检测，风险预测模型，影响治疗反应的因素以及癌症研究中的其他新兴领域的研究。

DESCRIPTION (provided by applicant): Prospective cancer epidemiology cohorts (CECs) can simultaneously investigate how genes, biomarkers, the environment, and lifestyle together affect cancer incidence, mortality, and clinical outcomes. The prospective California Teachers Study (CTS) began in 1995, when 133,479 female public school professionals completed a self-administered questionnaire. Participants have since completed three more questionnaires on lifestyle and environmental exposures. CTS data are regularly linked with California databases to identify essentially all incident cancers, hospitalizations, and deaths. CTS participants have donated 5,428 blood and 7,549 saliva samples in targeted projects to date. To enable broader etiologic, clinical, and translational research on genetic, molecular, and environmental predictors of cancer incidence, mortality, and outcomes, this project will collect pre diagnostic biospecimens from 27,625 CTS participants who have not previously donated a biospecimen. The specific aim is to collect, process, and store 1) a venous blood or saliva sample and 2) an overnight urine specimen from participants who are <70 years old and living in California. Coordinated teams of experienced field staff based at three CTS centers (City of Hope, Cancer Prevention Institute of California, and University of California, Irvine) will visit participants i person and collect, process, and store biospecimens using proven and standardized protocols. Adding this large group of pre diagnostic biospecimens to the extensive existing and future CTS risk-factor, cancer, hospitalization, and mortality data will directly facilitate numerous high-impact research projects in the CTS and in established large-scale consortia. This is an optimal time to collect new biospecimens because these participants will soon reach the age groups of peak cancer incidence. Combining the extensive exposure and lifestyle data collected in the CTS since 1995 with genetic, epigenetic, and other biomarkers in blood, urine, and saliva will directly facilitate future research on gene-environment interactions, natural history and progression, early detection, risk-prediction models, factors that affect response to treatment, and other emerging areas in cancer research.