New Biospecimens to Enhance Research in the California Teachers Study Cohort

描述(由申请人提供)：前瞻性癌症流行病学队列(CEC)可以同时调查基因、生物标记物、环境和生活方式如何共同影响癌症发病率、死亡率和临床结果。加州未来教师研究(CTS)始于1995年，当时有133,479名公立学校的女性专业人员完成了一份自填式问卷。自那以后，参与者又完成了三份关于生活方式和环境暴露的问卷。CTS数据定期与加州数据库链接，以识别基本上所有的偶发癌症、住院和死亡。到目前为止，CTS参与者在有针对性的项目中捐献了5428份血液和7549份唾液样本。实现对遗传、分子和环境预测因素的更广泛的病因学、临床和翻译研究 关于癌症发病率、死亡率和预后，该项目将收集27,625名CTS参与者的诊断前生物标本，这些参与者以前没有捐献过生物标本。其具体目标是收集、处理和存储1)静脉血液或唾液样本和2)70岁以上居住在加利福尼亚州的参与者的过夜尿样。由三个CTS中心(希望之城、加州癌症预防研究所和加州大学欧文分校)的经验丰富的现场工作人员组成的协调团队将亲自拜访参与者，并使用经过验证和标准化的协议收集、处理和存储生物标本。将这一大组诊断前生物样本添加到广泛的现有和未来CTS风险因素、癌症、住院和死亡率数据中，将直接促进CTS和现有大型财团中的许多高影响力研究项目。这是收集新生物检疫药物的最佳时机，因为这些参与者很快就会达到癌症发病率最高的年龄段。将CTS自1995年以来收集的广泛暴露和生活方式数据与血液、尿液和唾液中的遗传、表观遗传和其他生物标记物相结合，将直接促进未来癌症研究中基因-环境相互作用、自然历史和进展、早期发现、风险预测模型、影响治疗反应的因素以及其他新兴领域的研究。

DESCRIPTION (provided by applicant): Prospective cancer epidemiology cohorts (CECs) can simultaneously investigate how genes, biomarkers, the environment, and lifestyle together affect cancer incidence, mortality, and clinical outcomes. The prospective California Teachers Study (CTS) began in 1995, when 133,479 female public school professionals completed a self-administered questionnaire. Participants have since completed three more questionnaires on lifestyle and environmental exposures. CTS data are regularly linked with California databases to identify essentially all incident cancers, hospitalizations, and deaths. CTS participants have donated 5,428 blood and 7,549 saliva samples in targeted projects to date. To enable broader etiologic, clinical, and translational research on genetic, molecular, and environmental predictors of cancer incidence, mortality, and outcomes, this project will collect pre diagnostic biospecimens from 27,625 CTS participants who have not previously donated a biospecimen. The specific aim is to collect, process, and store 1) a venous blood or saliva sample and 2) an overnight urine specimen from participants who are <70 years old and living in California. Coordinated teams of experienced field staff based at three CTS centers (City of Hope, Cancer Prevention Institute of California, and University of California, Irvine) will visit participants i person and collect, process, and store biospecimens using proven and standardized protocols. Adding this large group of pre diagnostic biospecimens to the extensive existing and future CTS risk-factor, cancer, hospitalization, and mortality data will directly facilitate numerous high-impact research projects in the CTS and in established large-scale consortia. This is an optimal time to collect new biospecimens because these participants will soon reach the age groups of peak cancer incidence. Combining the extensive exposure and lifestyle data collected in the CTS since 1995 with genetic, epigenetic, and other biomarkers in blood, urine, and saliva will directly facilitate future research on gene-environment interactions, natural history and progression, early detection, risk-prediction models, factors that affect response to treatment, and other emerging areas in cancer research.