New Biospecimens to Enhance Research in the California Teachers Study Cohort

新的生物样本将加强加州教师研究队列的研究

基本信息

  • 批准号:
    8917892
  • 负责人:
  • 金额:
    $ 275.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-09-24 至 2017-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Prospective cancer epidemiology cohorts (CECs) can simultaneously investigate how genes, biomarkers, the environment, and lifestyle together affect cancer incidence, mortality, and clinical outcomes. The prospective California Teachers Study (CTS) began in 1995, when 133,479 female public school professionals completed a self-administered questionnaire. Participants have since completed three more questionnaires on lifestyle and environmental exposures. CTS data are regularly linked with California databases to identify essentially all incident cancers, hospitalizations, and deaths. CTS participants have donated 5,428 blood and 7,549 saliva samples in targeted projects to date. To enable broader etiologic, clinical, and translational research on genetic, molecular, and environmental predictors of cancer incidence, mortality, and outcomes, this project will collect pre diagnostic biospecimens from 27,625 CTS participants who have not previously donated a biospecimen. The specific aim is to collect, process, and store 1) a venous blood or saliva sample and 2) an overnight urine specimen from participants who are <70 years old and living in California. Coordinated teams of experienced field staff based at three CTS centers (City of Hope, Cancer Prevention Institute of California, and University of California, Irvine) will visit participants i person and collect, process, and store biospecimens using proven and standardized protocols. Adding this large group of pre diagnostic biospecimens to the extensive existing and future CTS risk-factor, cancer, hospitalization, and mortality data will directly facilitate numerous high-impact research projects in the CTS and in established large-scale consortia. This is an optimal time to collect new biospecimens because these participants will soon reach the age groups of peak cancer incidence. Combining the extensive exposure and lifestyle data collected in the CTS since 1995 with genetic, epigenetic, and other biomarkers in blood, urine, and saliva will directly facilitate future research on gene-environment interactions, natural history and progression, early detection, risk-prediction models, factors that affect response to treatment, and other emerging areas in cancer research.
描述(由申请人提供):前瞻性癌症流行病学队列(CECs)可以同时研究基因、生物标志物、环境和生活方式如何共同影响癌症发病率、死亡率和临床结果。前瞻性的加州教师研究(CTS)开始于1995年,133479名公立学校的女性专业人员完成了一份自我管理的问卷。此后,参与者又完成了三份关于生活方式和环境暴露的调查问卷。CTS数据定期与加州数据库相关联,以确定基本上所有的癌症、住院和死亡事件。迄今为止,CTS参与者已在目标项目中捐赠了5428份血液和7549份唾液样本。使更广泛的病因学、临床和转化研究的遗传、分子和环境预测

项目成果

期刊论文数量(0)
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James V Lacey其他文献

Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction
欧洲血统人群多基因评分分布的差异:对乳腺癌风险预测的影响
  • DOI:
    10.1101/2024.02.12.24302043
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kristia Yiangou;N. Mavaddat;J. Dennis;M. Zanti;Qin Wang;M. Bolla;Mustapha Abubakar;T. Ahearn;I. Andrulis;H. Anton;N. Antonenkova;V. Arndt;K. Aronson;A. Augustinsson;Adinda Baten;S. Behrens;M. Bermisheva;Amy Berrington de González;K. Białkowska;N. Boddicker;C. Bodelón;N. Bogdanova;S. Bojesen;K. Brantley;H. Brauch;H. Brenner;Nicola J. Camp;F. Canzian;J. Castelao;Melissa H. Cessna;J. Chang;G. Chenevix;Wendy K. Chung;Sarah V Colonna;F. Couch;A. Cox;Simon S. Cross;K. Czene;M. Daly;P. Devilee;T. Dörk;A. Dunning;Diana M. Eccles;A. Eliassen;Christoph Engel;M. Eriksson;D. G. Evans;Peter A. Fasching;O. Fletcher;H. Flyger;L. Fritschi;M. Gago;A. Gentry;A. González;P. Guénel;E. Hahnen;C. Haiman;U. Hamann;Jaana M. Hartikainen;Vikki Ho;James M. Hodge;A. Hollestelle;E. Honisch;M. Hooning;Reiner Hoppe;J. Hopper;Sacha J. Howell;A. Howell;Simona Jakovchevska;A. Jakubowska;H. Jernström;N. Johnson;Rudolf Kaaks;Elza K. Khusnutdinova;C. Kitahara;Stella Koutros;V. Kristensen;James V Lacey;D. Lambrechts;F. Lejbkowicz;A. Lindblom;M. Lush;A. Mannermaa;Dimitrios Mavroudis;Usha Menon;Rachel Murphy;H. Nevanlinna;Nadia Obi;K. Offit;Tjoung;A. Patel;Cheng Peng;P. Peterlongo;G. Pita;D. Plaseska‐Karanfilska;K. Pylkäs;P. Radice;M. U. Rashid;Gadi Rennert;Eleanor Roberts;Juan Rodriguez;A. Romero;E. Rosenberg;E. Saloustros;Dale P. Sandler;E. Sawyer;Rita Schmutzler;C. Scott;X. Shu;M. Southey;Jennifer Stone;Jack A. Taylor;Lauren R. Teras;I. van de Beek;Walter Willett;R. Winqvist;W. Zheng;C. Vachon;M. Schmidt;Per Hall;R. MacInnis;R. Milne;Paul D. P. Pharoah;J. Simard;A. Antoniou;Douglas F. Easton;K. Michailidou
  • 通讯作者:
    K. Michailidou
Association of tea and coffee consumption and biliary tract cancer risk: The Biliary Tract Cancers Pooling Project
茶和咖啡消费与胆道癌风险的关联:胆道癌汇集项目
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    13.5
  • 作者:
    Yu;E. Loftfield;Ilona Argirion;Hans;D. Albanes;A. T. Chan;V. Fedirko;G.E. Fraser;Neal D. Freedman;Graham G. Giles;Patricia Hartge;Verena A. Katzke;S. Knutsen;James V Lacey;Linda M. Liao;Juhua Luo;R. Milne;K. O’Brien;Ulrike Peters;J. Poynter;M. Purdue;K. Robien;Sven Sandin;Dale P. Sandler;V. Setiawan;Jae H. Kang;Tracey G. Simon;Rashmi Sinha;T. VoPham;S. Weinstein;Emily White;Xuehong Zhang;Bin Zhu;K. McGlynn;P. Campbell;Mei;J. Koshiol
  • 通讯作者:
    J. Koshiol
A likelihood ratio approach for utilizing case-control data in the clinical classification of rare sequence variants: application to BRCA1 and BRCA2.
在罕见序列变异的临床分类中利用病例对照数据的似然比方法:应用于 BRCA1 和 BRCA2。
  • DOI:
    10.1155/2023/9961341
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    M. Zanti;Denise G. O’Mahony;Michael T. Parsons;Hongyan Li;J. Dennis;Kristiina Aittomäkkiki;I. Andrulis;H. Anton;K. Aronson;A. Augustinsson;Heiko Becher;S. Bojesen;M. Bolla;H. Brenner;Melissa A. Brown;S. Buys;F. Canzian;S. Caputo;J. Castelao;J. Chang;GC;K. Czene;M. Daly;Arcangela De Nicolo;P. Devilee;T. Dörk;A. Dunning;M. Dwek;D. Eccles;C. Engel;David Evans;P. Fasching;M. Gago;M. García;J. García;A. Gentry;Willemina R. R. Geurts ;G. Giles;G. Glendon;M. Goldberg;E. G. Gómez Garcia;Melanie Güendert;P. Guénel;E. Hahnen;C. Haiman;P. Hall;U. Hamann;E. Harkness;Frans B. L. Hogervorst;A. Hollestelle;Reiner Hoppe;J. Hopper;C. Houdayer;R. Houlston;A. Howell;ABCTB Investigators;M. Jakimovska;A. Jakubowska;H. Jernström;E. John;R. Kaaks;C. Kitahara;Stella Koutros;P. Kraft;V. Kristensen;James V Lacey;D. Lambrechts;M. Léoné;A. Lindblom;J. Lubiński;M. Lush;A. Mannermaa;M. Manoochehri;S. Manoukian;S. Margolin;M. E. Martinez;Usha Menon;R. Milne;A. Monteiro;R. A. Murphy;S. Neuhausen;H. Nevanlinna;W. G. Newman;K. Offit;Sue;P. James;P. Peterlongo;J. Peto;D. Plaseska‐Karanfilska;K. Punie;P. Radice;Muhammad Abo ul Hassan Rashid;G. Rennert;A. Romero;E. Rosenberg;E. Saloustros;D. Sandler;M. Schmidt;R. Schmutzler;X. Shu;J. Simard;M. Southey;J. Stone;D. Stoppa;R. Tamimi;W. Tapper;Jack A. Taylor;Soo;Lauren R. Teras;M. Terry;M. Thomassen;M. Troester;C. Vachon;Ana Vega;M. Vreeswijk;Qin Wang;B. Wappenschmidt;C. R. Weinberg;A. Wolk;W. Zheng;Bing;F. Couch;A. Spurdle;D. Easton;D. Goldgar;K. Michailidou
  • 通讯作者:
    K. Michailidou

James V Lacey的其他文献

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{{ truncateString('James V Lacey', 18)}}的其他基金

Genome-wide genotyping of existing samples from Asian American and Pacific Islander participants in the California Teachers Study cohort to facilitate broad and open future research
对加州教师研究队列中亚裔美国人和太平洋岛民参与者的现有样本进行全基因组基因分型,以促进广泛和开放的未来研究
  • 批准号:
    10408476
  • 财政年份:
    2015
  • 资助金额:
    $ 275.72万
  • 项目类别:
Innovative Infrastructure to Enhance and Sustain the California Teachers Study Cohort
创新基础设施,以增强和维持加州教师研究队伍
  • 批准号:
    10686141
  • 财政年份:
    2015
  • 资助金额:
    $ 275.72万
  • 项目类别:
Innovative Infrastructure to Enhance and Sustain the California Teachers Study Cohort
创新基础设施,以增强和维持加州教师研究队伍
  • 批准号:
    10259758
  • 财政年份:
    2015
  • 资助金额:
    $ 275.72万
  • 项目类别:
Genome-wide genotyping of existing samples in the California Teachers Study cohort from under-represented racial & ethnic minority groups to facilitate broad and open future research
对加州教师研究队列中代表性不足的种族的现有样本进行全基因组基因分型
  • 批准号:
    10629670
  • 财政年份:
    2015
  • 资助金额:
    $ 275.72万
  • 项目类别:
Innovative Infrastructure to Enhance and Sustain the California Teachers Study Cohort
创新基础设施,以增强和维持加州教师研究队伍
  • 批准号:
    10053181
  • 财政年份:
    2015
  • 资助金额:
    $ 275.72万
  • 项目类别:
Innovative Infrastructure to Enhance and Sustain the California Teachers Study Cohort
创新基础设施,以增强和维持加州教师研究队伍
  • 批准号:
    10478112
  • 财政年份:
    2015
  • 资助金额:
    $ 275.72万
  • 项目类别:
Oil and Gas as Drivers of Climate Change and Health: Developing unique resources to investigate multi-level and diverse effects of exposure to oil and gas wells
石油和天然气作为气候变化和健康的驱动因素:开发独特的资源来调查接触石油和天然气井的多层次和多样化的影响
  • 批准号:
    10839157
  • 财政年份:
    2015
  • 资助金额:
    $ 275.72万
  • 项目类别:
A More Perfect Union: Leveraging Clinically Deployed Models and Cancer Epidemiology Cohort Data to Improve AI/ML Readiness of NIH-Supported Population Sciences Resources
更完美的联盟:利用临床部署的模型和癌症流行病学队列数据来提高 NIH 支持的人口科学资源的 AI/ML 准备情况
  • 批准号:
    10594304
  • 财政年份:
    2015
  • 资助金额:
    $ 275.72万
  • 项目类别:
New Biospecimens to Enhance Research in the California Teachers Study Cohort
新的生物样本将加强加州教师研究队列的研究
  • 批准号:
    8550025
  • 财政年份:
    2012
  • 资助金额:
    $ 275.72万
  • 项目类别:
New Biospecimens to Enhance Research in the California Teachers Study Cohort
新的生物样本将加强加州教师研究队列的研究
  • 批准号:
    8374426
  • 财政年份:
    2012
  • 资助金额:
    $ 275.72万
  • 项目类别:

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Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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How age dependent molecular changes in T follicular helper cells affect their function
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