Innovative Infrastructure to Enhance and Sustain the California Teachers Study Cohort

项目摘要/摘要 加州教师研究(CTS)收集了高质量和详细的暴露、生物显微镜、癌症、 自1995年以来，跟踪了133,477名女性志愿者的临床终点数据。癌症，住院， 到目前为止，死亡人数还不到CTS预计在未来30年发生的终端总数的一半 好几年了。在接下来的5年里，CTS的随访将包括37,000多例癌症；455,000例住院治疗；以及 41000人死亡。这为利用这些独特的资源进行合作研究提供了坚实的基础。自.以来 2013年，CTS从14,674名参与者中收集了新的血液样本。云计算和集成移动 设备生成了丰富的表型数据和极低的分析前变异性488,000等分 随着CTS后续行动的继续进行。自2015年以来，CTS对其数据收集、存储和 通过实施安全的数据仓库和设计的灵活分析环境来分析基础架构 用于高质量和综合的流行病学分析。CTS包括安全用户身份验证和 授权；包含文档、数据可视化、工具和工作流的协作工作区；元数据； 应用程序编程接口(API)功能；以及可伸缩数据模型。CTS现在的定位是 精简资源，实现长期可持续发展。这种相互竞争的更新的目标是保护 支持研究的现有资源，并从战略上扩展创造高价值机会的领域。 首先，我们将维护现有的CTS数据，并通过有效的癌症、住院、 和死亡的联系。这些正在进行的联系将产生用于未来病因学的额外终点， 财团、老龄化和其他研究。第二，我们将存储收集的48.8万个高质量的生物标本 自2013年以来。这些标本目前对每个人都是可用的；持续的存储将确保它们 对所有人保持可用状态。第三，我们将通过整合更多的目标地理空间数据来扩大容量 关于气候、极端天气、建成环境、社区特征、健康通道、环境 暴露、社会脆弱性和社区复原力。新的CTS基础设施可高效实现 每个人，无论他们的GIS专业知识如何，都会严格地将个人级别的地理空间暴露合并到 他们的分析。第四，由于大多数参与者现在超过65岁，我们将把CTS与联邦医疗保险联系起来 门诊数据，以补充现有数据并扩展针对老龄化、存活率、共病和 健康服务研究。最近的CTS基础架构更新增加了可供研究使用的管理效率 并以帮助所有研究人员的方式处理复杂的地理空间、行政主张和其他CTS数据， 特别是CTS以外的机构，开展综合性、严谨和可重复的研究。CTS是一个 拥有基础资产和数十年未来研究潜力的创新领导者。这场竞争 续订将保持高价值的CTS资源，可以解决未被研究的研究领域，促进 整个科学界更广泛地使用，并简化CTS，以实现长期可持续性。

PROJECT SUMMARY / ABSTRACT The California Teachers Study (CTS) has collected high-quality and detailed exposure, biospecimens, cancer, and clinical endpoint data on 133,477 female volunteers followed since 1995. The cancers, hospitalizations, and deaths to date are less than half of the total endpoints projected to occur in the CTS over the next 30 years. In the next 5 years, CTS follow-up will include over 37,000 cancers; 455,000 hospitalizations; and 41,000 deaths. This provides a solid foundation for collaborative research using these unique resources. Since 2013, the CTS collected new blood samples from 14,674 participants. Cloud computing and integrated mobile devices generated rich phenotype data and exceptionally low pre-analytical variability for 488,000 aliquots that are being stored as CTS follow-up continues. Since 2015, the CTS modernized its data collection, storage, and analysis infrastructure by implementing a secure data warehouse and flexible analytics environment designed for high-quality and integrated epidemiologic analysis. The CTS includes secure user authentication & authorization; a collaborative workspace with documents, data visualizations, tools, and workflows; metadata; application programming interface (API) capabilities; and a scalable data model. The CTS is now positioned to streamline its resources for long-term sustainability. The goals of this competing renewal are to preserve existing resources that enable research and strategically expand areas that create high-value opportunities. First, we will maintain existing CTS data and extend passive follow-up through efficient cancer, hospitalization, and mortality linkages. These ongoing linkages will generate additional endpoints used for future etiologic, consortial, aging, and other research. Second, we will store the 488,000 high-quality biospecimens collected since 2013. These specimens are all currently available to everyone; ongoing storage will ensure that they remain available to everyone. Third, we will expand capacity by integrating additional targeted geospatial data on climate, extreme weather, built environment, community characteristics, health access, environmental exposures, social vulnerability, and community resilience. The new CTS infrastructure efficiently enables everyone, regardless of their GIS expertise, to rigorously incorporate individual-level geospatial exposures into their analyses. Fourth, because most participants are now over age 65, we will link the CTS with Medicare outpatient data to complement existing data and expand infrastructure for aging, survivorship, comorbidity, and health services research. The recent CTS infrastructure updates added research-ready efficiencies to manage and process complex geospatial, administrative claims, and other CTS data in ways that help all researchers, especially those outside the CTS, conduct integrative, rigorous, and reproducible research. The CTS is an innovation leader with primed assets and decades of promising future research potential. This competing renewal will maintain high-value CTS resources that can address understudied research areas, facilitate broader use by the entire scientific community, and streamline the CTS for long-term sustainability.