Center for Cancer Nanotechnology Excellence and Translation (CCNE-T)

癌症纳米技术卓越与转化中心 (CCNE-T)

• 批准号: 8540368
• 负责人: SANJIV S GAMBHIR
• 金额: $ 233.45万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-26 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540368
• 关键词: Aftercare; Animal Model; Area; Biochemical Pathway; Biological Markers; Biopsy; Blood; Blood Proteins; Blood Tests; California; Cancer Biology; Cancer Center; Cancer Patient; Cell Separation; Cells; Chemistry; Clinical; Clinical Trials; Communities; Devices; Diagnostic; Diagnostic Neoplasm Staging; Early Diagnosis; Early Intervention; Early treatment; Engineering; Ensure; Five-Year Plans; Foundations; Funding; Future; Goals; Grant; Heterogeneity; Image; Imaging technology; In Vitro; Individual; Institutes; Link; Location; Los Angeles; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Massachusetts; Measures; Methods; Molecular Biology Techniques; Monitor; Nanotechnology; National Cancer Institute; Neoplasm Circulating Cells; Outcome; Ovarian; Patients; Phosphotransferases; Physicians; Positron-Emission Tomography; Protein Engineering; Proteins; Proteomics; Regimen; Research Project Grants; Research Proposals; Resources; Sampling; Science; Scientist; Screening for Ovarian Cancer; Screening for cancer; Serinus; Signal Transduction; Site; Staging; Survival Rate; TNFRSF5 gene; Technology; Testing; Therapeutic; Therapeutic Intervention; Time; Translating; Translations; Tumor Burden; Universities; Validation; Vision; anticancer research; base; cancer diagnosis; cancer therapy; cost; improved; in vivo; in vivo Cellular and Molecular Imaging Centers; innovation; mathematical model; meter; molecular imaging; multidisciplinary; nano; nanofabrication; nanoparticle; nanoscience; nanosensors; nanosystems; next generation; novel; oncology; outreach; physical science; programs; response; tumor

DESCRIPTION (provided by applicant): This Center for Cancer Nanotechnology Excellence and Translation (CCNE-T) brings together scientists and physicians from Stanford University, University of California Berkeley/Lawrence Berkeley National Lab, University of California Los Angeles, University of Southern California and the Massachusetts Institute of Technology. The grant also leverages on several activities in cancer biomarker discovery/validation with the Canary Foundation and the Fred Hutchinson Cancer Center. This research proposal is centered around our vision that in vitro diagnostics used in conjunction with in vivo diagnostics can markedly impact future cancer patient management. Furthermore, we believe that nanotechnology can significantly advance both in vitro diagnostics through proteomic nanosensors and in vivo diagnostics through nanoparticles for molecular imaging. The cancer-related biochemical pathways targeted will be the Her kinase axis with a focus on predicting and monitoring response to lung cancer therapy. An additional focus will be on the earlier detection of Ovarian Cancer. We have assembled a highly interdisciplinary team of scientists from the fields of chemistry, materials science and engineering, molecular imaging, oncology, cancer biology, protein engineering, and mathematical modeling in order to accomplish our goals. We highly leverage resources at the Stanford Bio-X and Nanoscale Science and Engineering Programs, the California Nanosystems Institute, and the Cancer Centers of Stanford/UCL/VUSC/Fred Hutchinson. We will utilize significant resources at several small companies we have started and General Electric. We have direct links to a Fred Hutchinson Ovarian SPORE, a recently funded Physical Sciences Oncology Center (PSOC), the ICMIC P50, ICBP, and NTR at Stanford. Furthermore, the Canary Foundation will provide more than $3M towards clinical trials to translate our nanotechnologies and help with outreach. Four research projects and three cores are proposed. Project #1 focuses on novel smart nanoparticles including Raman and self-assembling nanoparticles, Project #2 focuses on the use of magneto-nanotechnology for blood proteomics and cell sorting. Project #3 focuses on the use of multiple nano-platforms to interrogate single circulating tumor cells. Project #4 focuses on molecular imaging of ovarian cancer with photoacoustics and Raman nanoparticles, and monitoring response to therapy using imaging and magneto-nanosensors. Core #1 will facilitate Nanoinformatics, Core #2 will provide resources for nanocharacterization and nanofabrication, Core #3 will facilitate clinical translation by linking our nanotechnologies to existing patient samples and ongoing as well as new clinical trials. With our highly interactive and cohesive program focused on developing and validating nanotechnology for anti-cancer therapy response and earlier cancer detection, we will imagine, invent, and innovate for the benefit of cancer patients.

描述（由申请人提供）：该癌症纳米技术中心卓越和翻译（CCNE-T）汇集了斯坦福大学，加利福尼亚大学伯克利分校/劳伦斯大学伯克利大学，加利福尼亚大学洛杉矶分校，南加州大学，南加州大学和马萨诸塞州技术研究所。该赠款还利用了Canary Foundation和Fred Hutchinson癌症中心的癌症生物标志物发现/验证的几项活动。这项研究建议集中在我们的愿景中，即与体内诊断相结合使用的体外诊断可能会显着影响未来的癌症患者管理。此外，我们认为，纳米技术可以通过蛋白质组学纳米传感器和通过纳米颗粒进行分子成像的体外诊断来显着提高体外诊断。靶向癌症相关的生化途径将是她的激酶轴，重点是预测和监测对肺癌治疗的反应。额外的重点将放在较早发现卵巢癌的地方。我们已经组建了一个高度跨学科的科学家团队，来自化学，材料科学和工程，分子成像，肿瘤学，癌症生物学，蛋白质工程和数学建模领域，以实现我们的目标。我们高度利用斯坦福BIO-X和纳米级科学与工程计划，加利福尼亚纳米系统研究所以及斯坦福/UCL/UCL/VUSC/Fred Hutchinson的癌症中心的资源。我们将在已经创办的几家小公司和通用电气中利用大量资源。我们与弗雷德·哈钦森卵巢孢子（Fred Hutchinson Ovarian Spore）有直接的联系，这是一个最近资助的物理科学肿瘤学中心（PSOC），斯坦福大学的ICMIC P50，ICBP和NTR。此外，金丝雀基金会将为临床试验提供超过300万美元的范围，以翻译我们的纳米技术并帮助外展。提出了四个研究项目和三个核心。项目＃1专注于新的智能纳米颗粒，包括拉曼和自组装纳米颗粒，项目＃2着重于将磁纳米技术用于血液蛋白质组学和细胞分类。项目＃3的重点是使用多个纳米平台来询问单个循环肿瘤细胞。项目＃4专注于具有光声和拉曼纳米颗粒的卵巢癌的分子成像，并使用成像和磁纳米传感器监测对治疗的反应。 Core＃1将促进纳米信息学，Core＃2将为纳米饰面和纳米制作提供资源，Core＃3将通过将我们的纳米技术与现有患者样品以及正在进行的新临床试验联系起来，从而促进临床翻译。由于我们高度互动和凝聚力的计划着重于开发和验证纳米技术以进行抗癌治疗反应，并提前癌症检测，因此，我们会想象，发明和创新为癌症患者受益。