Pilot Projects

这个癌症纳米技术卓越与翻译中心(CCNE-T)汇集了科学家和 来自斯坦福大学、加州大学伯克利分校/劳伦斯·伯克利国家实验室的医生们， 加州大学洛杉矶分校、南加州大学和麻省理工学院 技术。这笔赠款还利用了癌症生物标记物发现/验证方面的几项活动 金丝雀基金会和弗雷德·哈钦森癌症中心。这项研究提案围绕着 我们的设想是，体外诊断与体内诊断结合使用可以显著影响 未来的癌症患者管理。此外，我们认为纳米技术可以显著地 通过蛋白质组纳米传感器进行体外诊断和通过在体诊断 用于分子成像的纳米粒子。与癌症相关的生化途径将成为Herkinase的目标 Axis专注于预测和监测肺癌治疗的反应。一个额外的焦点 将致力于卵巢癌的早期发现我们已经组建了一个高度跨学科的团队 来自化学、材料科学和工程、分子成像、肿瘤学、 癌症生物学、蛋白质工程和数学建模，以实现我们的目标。我们高度重视 利用加州斯坦福大学生物X和纳米科学与工程计划的资源 纳米系统研究所和斯坦福大学/UCL/VuSC/弗雷德·哈钦森癌症中心。我们将利用 我们已经创办的几家小公司和通用电气的大量资源。我们有直接联系 给弗雷德·哈钦森的卵巢孢子，最近资助的物理科学肿瘤学中心(PSOC)， 斯坦福大学的ICMIC P50、ICBP和NTR。此外，金丝雀基金会将提供超过 300万美元用于临床试验，以转化我们的纳米技术并帮助推广。四项研究 提出了项目和三个核心。项目1专注于新型智能纳米粒子，包括拉曼 和自组装纳米粒子，项目2重点是将磁纳米技术用于血液 蛋白质组学和细胞分类。项目3的重点是使用多个纳米平台来审问单个 循环中的肿瘤细胞。项目4的重点是卵巢癌的光声分子成像和 拉曼纳米粒子，以及使用成像和磁纳米传感器监测治疗反应。堆芯 #1将促进纳米信息学，核心#2将为纳米表征和 纳米制造，Core#3将通过将我们的纳米技术与现有患者联系起来，促进临床翻译 样本和正在进行的临床试验以及新的临床试验。随着我们高度互动和凝聚力的计划专注于 关于开发和验证用于抗癌治疗反应和早期癌症检测的纳米技术， 我们将为癌症患者的利益设想、发明和创新。

This Center for Cancer Nanotechnology Excellence and Translation (CCNE-T) brings together scientists and physicians from Stanford University, University of California Berkeley/Lawrence Berkeley National Lab, University of California Los Angeles, University of Southern California and the Massachusetts Institute of Technology. The grant also leverages on several activities in cancer biomarker discovery/validation with the Canary Foundation and the Fred Hutchinson Cancer Center. This research proposal is centered around our vision that in vitro diagnostics used in conjunction with in vivo diagnostics can markedly impact future cancer patient management. Furthermore, we believe that nanotechnology can significantly advance both in vitro diagnostics through proteomic nanosensors and in vivo diagnostics through nanoparticles for molecular imaging. The cancer-related biochemical pathways targeted will be the Herkinase axis with a focus on predicting and monitoring response to lung cancer therapy. An additional focus will be on the earlier detection of Ovarian Cancer We have assembled a highly interdisciplinary team of scientists from the fields of chemistry, materials science and engineering, molecular imaging, oncology, cancer biology, protein engineering, and mathematical modeling in order to accomplish our goals. We highly leverage resources at the Stanford Bio-X and Nanoscale Science and Engineering Programs, the California Nanosystems Institute, and the Cancer Centers of Stanford/UCL/VUSC/Fred Hutchinson. We will utilize significant resources at several small companies we have started and General Electric. We have direct links to a Fred Hutchinson Ovarian SPORE, a recently funded Physical Sciences Oncology Center (PSOC), the ICMIC P50, ICBP, and NTR at Stanford. Furthermore, the Canary Foundation will provide more than $3M towards clinical trials to translate our nanotechnologies and help with outreach. Four research projects and three cores are proposed. Project #1 focuses on novel smart nanoparticles including Raman and self-assembling nanoparticles, Project #2 focuses on the use of magneto-nanotechnology for blood proteomics and cell sorting. Project #3 focuses on the use of multiple nano-platforms to interrogate single circulating tumor cells. Project #4 focuses on molecular imaging of ovarian cancer with photoacoustics and Raman nanoparticles, and monitoring response to therapy using imaging and magneto-nanosensors. Core #1 will facilitate Nanoinformatics, Core #2 will provide resources for nanocharacterization and nanofabrication, Core #3 will facilitate clinical translation by linking our nanotechnologies to existing patient samples and ongoing as well as new clinical trials. With our highly interactive and cohesive program focused on developing and validating nanotechnology for anti-cancer therapy response and earlier cancer detection, we will imagine, invent, and innovate for the benefit of cancer patients.