Vevo LAZR Photoacoustic and Ultrasound Imaging System

Vevo LAZR 光声和超声成像系统

• 批准号: 8447766
• 负责人: SANJIV S GAMBHIR
• 金额: $ 52.19万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-18 至 2014-06-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8447766
• 关键词: Acoustics; Animals; Applications Grants; Area; Basic Science; Biology; Biomedical Research; Cardiovascular Diseases; Cardiovascular system; Cerebral Neoplasm; Clinical; Communities; Contrast Media; Development; Diagnostic radiologic examination; Disease; Early Diagnosis; Frequencies; Goals; Gold; Health; Hemoglobin; Human; Image; Investigation; Laboratories; Melanins; Mission; Molecular; Molecular Probes; Neoplasm Metastasis; Optics; Patient Care; Patients; Public Health; Research; Resolution; Staging; System; Technology; Therapy Evaluation; Time; Ultrasonography; Universities; Visual; acoustic imaging; deoxyhemoglobin; imaging modality; imaging probe; insight; instrumentation; molecular imaging; multimodality; myocardial hypoxia; nanoparticle; photoacoustic imaging; single walled carbon nanotube; translational study; tumor microenvironment

DESCRIPTION (provided by applicant): The aim of this Shared Instrumentation Grant application is the acquisition of an upgrade of a Visual Sonics Vevo(R) 2100, to Vevo(R) LAZR Photo acoustic and Ultrasound Imaging System, allowing for the totally new imaging modality to be made available. This upgrade will have an enormous impact on the many projects, both basic science and translational, across Stanford University's diverse research community. The existing Vevo(R) 2100, a high frequency ultrasound, offers users the ability to view internal anatomical features with high spatial resolution. The proposed upgrade will allow photo acoustic imaging by contributing optical contrast, enabling real-time images possessing anatomical, functional and molecular information, extremely important for better understanding of underlying biology and for successful translational studies. Major research applications of the Vevo(R) photo acoustic technology are envisioned to be in the areas of oncological, cardiovascular and neuro- imaging. This technology allows imaging of both endogenous (hemoglobin, deoxyhemoglobin, melanin) and exogenous contrast agents and molecular probes (single walled carbon nanotubes, gold nanoparticles etc.) and as such will provide for our research community a unique insight into diverse studies, including investigations of the tumor microenvironment, metastases, cerebral and tumor hypoxia, and myocardial strain. In the long run, we believe these studies will have a profound impact on early detection of a range of disorders as well as on the improvement of various areas of patient care such as staging, therapy evaluation and overall patient management. Since clinical photo acoustic systems are under development by several groups, the small animal studies described herein are highly relevant to public health and support not only the biomedical research goals set at Stanford University but align well with NIH's mission of advancing human health through fundamental scientific discoveries. The investigations will take place at interdisciplinary laboratories directd by recognized leaders in biomedical research: multimodality molecular imaging (Dr. Sanjiv Sam Gambhir), molecular imaging probe development (Drs. Jianghong Rao and Zhen Cheng), cardiovascular disease (Drs. Euan Ashley, Joseph Wu and Ching-Pin Chang), and diagnostic radiology (Drs. Juergen Willmann, Amelie Lutz and Aya Kamaya).

描述（由申请人提供）：本共享仪器补助金申请的目的是将Visual Sonics Vevo（R）2100升级为Vevo（R）LAZR光声和超声成像系统，从而实现全新的成像模式。这一升级将对斯坦福大学多元化研究社区的许多项目产生巨大影响，包括基础科学和转化科学。现有的Vevo（R）2100是一种高频超声，为用户提供了以高空间分辨率查看内部解剖特征的能力。拟议的升级将通过提供光学对比度实现光声成像，从而实现具有解剖学、功能和分子信息的实时图像，这对于更好地理解基础生物学和成功的转化研究至关重要。设想Vevo（R）光声技术的主要研究应用是在肿瘤学、心血管和神经成像领域。该技术允许对内源性（血红蛋白、脱氧血红蛋白、黑色素）和外源性造影剂和分子探针（单壁碳纳米管、金纳米颗粒等）进行成像。因此，将为我们的研究团体提供对不同研究的独特见解，包括肿瘤微环境、转移、脑和肿瘤缺氧以及心肌应变的研究。从长远来看，我们相信这些研究将对一系列疾病的早期发现以及改善患者护理的各个领域产生深远的影响，例如分期，治疗评估和整体患者管理。由于临床光声系统正在由几个小组开发，本文所述的小动物研究与公共卫生高度相关，不仅支持斯坦福大学设定的生物医学研究目标，而且与NIH通过基础科学发现促进人类健康的使命保持一致。这些研究将在生物医学研究领域公认的领导者指导的跨学科实验室进行：多模态分子成像（Sanjiv Sam Gambhir博士），分子成像探针开发（Jianghong Rao博士和Zhen Cheng博士），心血管疾病（Euan阿什利博士，Joseph Wu博士和Ching-Pin Chang博士）以及诊断放射学（Juergen Willmann博士，Amelie Lutz博士和Aya Kamaya博士）。