Epidemiology of MRI parenchymal enhancement: A new marker of breast cancer risk

MRI实质增强的流行病学：乳腺癌风险的新标志

• 批准号: 8507632
• 负责人: Jennifer Dallas Brooks
• 金额: $ 8.6万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-09 至 2014-08-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8507632
• 关键词: Address; Age; Androstenedione; Area; Biological; Breast; Breast Cancer Risk Factor; Canada; Caring; Characteristics; Chemoprevention; Classification; Computer Assisted; Computer software; Contrast Media; Data; Development; Epidemiology; Estradiol; Estrone; Family; Foundations; Future; Goals; High Risk Woman; Hormonal; Hormones; Imagery; Kinetics; Magnetic Resonance Imaging; Malignant Neoplasms; Mammary Gland Parenchyma; Mammographic Density; Mammography; Measurement; Measures; Memorial Sloan-Kettering Cancer Center; Menopause; Menstrual cycle; Methods; Normal tissue morphology; Postmenopause; Premenopause; Preventive; Public Health; Recording of previous events; Relative Risks; Reproducibility; Research; Risk; Risk Marker; Serum; Sex Hormone-Binding Globulin; Tamoxifen; Testing; Time; Tissues; Treatment Protocols; Woman; Women' s Group; breast density; cancer risk; density; design; follow-up; high risk; hormone therapy; improved; malignant breast neoplasm; novel marker; radiologist; reproductive; response; response marker; screening; tumor

DESCRIPTION (provided by applicant): During breast MRI screening a contrast agent is administered to aid in the visualization of tumors, which enhances (becomes brighter). Normal breast tissue also enhances on MRI (termed background parenchymal enhancement [BPE]) and we have shown that the degree to which this normal tissue enhances is strongly associated with breast cancer risk. It is not clear why this would be the case and the biological underpinnings of what this enhancement represents are not known. The objective of the current study is to determine the relationship between known breast cancer risk factors and BPE and to develop and validate a computer-assisted quantitative approach to the measurement of BPE. It is hypothesized that BPE may represent the breast tissue response to the hormonal profile of a woman, making it a good indicator of breast cancer risk. This will be the largest study of BPE measurements in any group of women to date and the first to address the need for a quantitative method of measurement. Three specific aims will be addressed to test our primary hypothesis and to address the overall objective of this application: 1) Develop and validate an objective quantitative measure of BPE using software for analyzing breast MRIs available at Memorial Sloan-Kettering Cancer Center (MSKCC), 2) Explore the relationship between BPE on MRI and known breast cancer risk factors in healthy high-risk pre- and post-menopausal women and 3) Determine the relationship between serum hormone levels at the time of MRI and degree of BPE in healthy high-risk postmenopausal women. The results of this study will provide crucial information regarding the relationship between BPE, a new highly predictive indicator of breast cancer risk, and known breast cancer risk factors including circulating levels of hormones. Additionally, the quantitative method developed here will yield a continuous measure of BPE, one that is expected to provide a more accurate picture of the relationship between BPE and breast cancer risk than the four-point categorical scale used by radiologists. This will allow for better classification of already high-risk women (i.e., those with a family or personal history of breast cancer). The proposed research is significant because it will begin to characterize this novel marker of risk, providing the foundation necessary for future studies exploring the relationship between BPE and breast cancer risk.

描述(申请人提供)：在乳腺MRI筛查期间，使用造影剂来帮助显示肿瘤，增强(变得更亮)。正常乳腺组织也会在MRI上增强(称为背景实质增强[BPE])，我们已经表明，这种正常组织增强的程度与乳腺癌风险密切相关。目前尚不清楚为什么会出现这种情况，这种增强所代表的生物学基础也不清楚。本研究的目的是确定已知的乳腺癌危险因素与BPE之间的关系，并开发和验证一种计算机辅助的定量方法来测量BPE。据推测，BPE可能代表了乳腺组织对女性荷尔蒙水平的反应，使其成为乳腺癌风险的良好指标。这将是迄今为止在所有妇女群体中对BPE测量进行的最大规模的研究，也是第一次解决对定量测量方法的需求。我们将致力于三个具体目标来验证我们的主要假设并解决这一应用的总体目标：1)使用纪念斯隆-凯特琳癌症中心(MSKCC)提供的用于分析乳腺MRI的软件来开发和验证BPE的客观定量测量；2)在健康的高危绝经前后探索MRI上的BPE与已知乳腺癌风险因素的关系；以及3)确定健康的高危绝经后妇女在进行MRI检查时的激素水平与BPE程度的关系。这项研究的结果将提供关于BPE(一种新的高度预测乳腺癌风险的指标)与已知的乳腺癌风险因素(包括循环激素水平)之间的关系的关键信息。此外，这里开发的定量方法将产生BPE的连续测量，与放射科医生使用的四分分类标准相比，这种方法有望更准确地描述BPE和乳腺癌风险之间的关系。这将有助于对已经处于高危状态的妇女(即有乳腺癌家族或个人病史的妇女)进行更好的分类。这项拟议的研究意义重大，因为它将开始描述这种新的风险标记物，为未来探索BPE和乳腺癌风险之间的关系提供必要的基础。

项目成果

MRI background parenchymal enhancement, breast density and breast cancer risk factors: A cross-sectional study in pre- and post-menopausal women.

• DOI: 10.1038/s41523-022-00458-2
• 发表时间: 2022-08-25
• 期刊: NPJ BREAST CANCER
• 影响因子: 5.9
• 作者: Brooks, Jennifer D.;Christensen, Rebecca A. G.;Sung, Janice S.;Pike, Malcolm C.;Orlow, Irene;Bernstein, Jonine L.;Morris, Elizabeth A.
• 通讯作者: Morris, Elizabeth A.