Parvin Building Animal Resources Center Improvement Plan

帕尔文大楼动物资源中心改进计划

• 批准号: 8525901
• 负责人: RICHARD W ERMEL
• 金额: $ 48.06万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8525901
• 关键词: AIDS-Related Lymphoma; Accreditation; Achievement; Activities of Daily Living; Address; Animal Experimentation; Animal Housing; Animal Model; Animal Welfare; Animals; Antineoplastic Agents; Area; Avastin; Biomedical Research; Biotechnology; Breeding; Capital; Caring; Censuses; Cities; Clinical Services; Clinical Trials; Collaborations; Comprehensive Cancer Center; Development; Diabetes Mellitus; Disease; Division of Clinical Sciences; Duct (organ) structure; Ensure; Equipment; Extramural Activities; FDA approved; Faculty; Funding; Future; Genetic Engineering; Growth; Heart; Housing; Human; IACUC; Indoor Air Quality; Institution; Insulin; International; Laboratory Animals; Leadership; Life; Link; Los Angeles; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Medicine; Minor; Modification; Molecular Genetics; Monoclonal Antibodies; Mus; National Cancer Institute; Phase; Prevention; Principal Investigator; Process; Protocols documentation; RNA Interference; Recording of previous events; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Roche brand of rituximab; Roche brand of trastuzumab; Rodent; Science; Services; Strategic Planning; System; Translational Research; United States Department of Agriculture; United States National Institutes of Health; Water; animal care; animal facility; animal resource; base; cigarette smoking; comparative; density; design; diabetic; exhaust; falls; improved; innovation; meetings; novel therapeutics; pre-clinical research; preclinical study; programs

DESCRIPTION (provided by applicant): The Parvin Building Animal Resources Center Improvement Plan will significantly increase the animal holding capacity for animal models used in breeding and research activities at the Beckman Research Institute of City of Hope (COH/BRI) and will substantially optimize space utilization at the Division of Comparative Medicine within the centralized Animal Resources Center (ARC) animal facility. Over the past decade, COH/BRI has grown both in research staff (25%) and extramural funding (120%) through the direction of a purposeful, strategic plan to increase biomedical research in the areas of novel therapeutics for catastrophic diseases- mainly cancer and diabetes. This increase in funding has been accompanied by an increase in the number of IACUC-approved animal use protocols (from 118 to 230), and the average daily animal census has increased more than five-fold. As a result, the ARC has recently reached its functional operational capacity, and is facing a critical juncture, challenged with providing enough space and enhanced services to meet the current needs of animal-based research programs (short-term), as well as to plan for continued growth (long-term). COH/BRI has identified animal facility improvement and expansion as a strategic necessity, and is in the process of designing an expansion to the facility. Although the institution has moved forward with minor renovations and equipment acquisition, animal housing currently available is only able to meet current needs, and cannot accommodate new projects or our anticipated future growth in pre-clinical and translational research programs involving animal models. Unless the current ARC animal holding space shortage is addressed, potential disruptions, delays or curtailment of animal model-based research projects may occur. Therefore, the requested space efficient, high density, ventilated rodent housing systems and associated equipment are urgently needed to maintain and further develop our innovative institutional biomedical and translational research programs, while also facilitating new research initiatives, by increasing the animal facility holding capacity and improving operational efficiencies. The requested high density animal housing systems will be used to replace older, less space efficient, ventilated housing systems in two mouse breeding rooms in the animal facility. This will allow the ARC to optimize space utilization in the current facility, and after he facility expansion, while also increasing efficiencies in labor and energy and improving indoor air quality. The requested equipment will support the successful completion of 78 ($23.5M) active and 122 ($35.3M) pending projects involving animal model research, and will help to ensure COH/BRI continues its remarkable history of innovation and achievements in science and medical care.

描述（由申请人提供）：Parvin Building Animal Resources Center Improvement Plan将显著增加Beckman Research Institute of City of Hope（COH/BRI）用于育种和研究活动的动物模型的动物容纳能力，并将大大优化中央动物资源中心（ARC）动物设施内比较医学部门的空间利用率。在过去的十年中，COH/BRI通过有目的的战略计划的方向，增加了研究人员（25%）和校外资金（120%），以增加灾难性疾病（主要是癌症和糖尿病）新疗法领域的生物医学研究。随着资金的增加，IACUC批准的动物使用协议数量也有所增加（从118个增加到230个），平均每天的动物普查增加了五倍多。因此，ARC最近达到了其功能运营能力，并面临着一个关键时刻，面临着提供足够空间和增强服务的挑战，以满足动物研究项目的当前需求（短期），以及规划持续增长（长期）。COH/BRI已将动物设施的改善和扩建确定为战略必要性，并正在设计扩建设施。尽管该机构已经进行了小规模的翻新和设备购置，但目前可用的动物饲养只能满足当前的需求，无法容纳新项目或我们在涉及动物模型的临床前和转化研究项目中的预期未来增长。除非目前ARC动物饲养空间短缺的问题得到解决，否则可能会发生基于动物模型的研究项目的中断、延迟或缩减。因此，迫切需要所要求的空间有效、高密度、通风的啮齿动物住房系统和相关设备，以维持和进一步发展我们的创新机构生物医学和转化研究计划，同时还通过增加动物设施容纳能力和提高运营效率来促进新的研究计划。所要求的高密度动物饲养系统将用于替换动物设施中两个小鼠饲养室中较旧、空间效率较低的通风饲养系统。这将使ARC能够优化当前设施和设施扩建后的空间利用率，同时提高劳动力和能源效率并改善室内空气 质量.所要求的设备将支持78个（2350万美元）正在进行的项目和122个（3530万美元）悬而未决的项目的成功完成，这些项目涉及动物模型研究，并将有助于确保COH/BRI继续其在科学和医疗保健方面的创新和成就的卓越历史。