Emerging Papillomaviruses in Immunosuppressed Dogs

描述（由申请人提供）：犬在实验室医学中发挥着重要作用，从毒理学和药代动力学研究到遗传治疗和骨髓移植。新出现的乳头状瘤病毒感染及其诱发的肿瘤使免疫抑制犬的研究越来越复杂。狗的免疫反应缺陷主要是研究用于治疗皮肤病、神经病和免疫病的新药的结果。此外，骨髓移植的开创性实验也干扰了正常的宿主免疫力，使狗容易感染乳头瘤病毒。为了解决这个问题，我们建议确定负责这些感染的犬乳头瘤病毒，以评估狗被感染的时间，并开发预防性疫苗。我们研究的最终目标是开发疫苗，使研究人员能够在不受严重乳头瘤病毒感染影响的情况下进行医学研究。

DESCRIPTION (provided by applicant): Dogs play a central role in laboratory medicine, ranging from studies of toxicology and pharmacokinetics to genetic therapy and bone marrow transplantation. Emerging papillomavirus infections and the tumors that they induce are increasingly complicating the study of immunosuppressed dogs. Defective immune responses in dogs are primarily the consequence of studying new drugs for treating dermatologic, neurologic and immunologic diseases. In addition, pioneering experiments on bone marrow transplantation also interfere with normal host immunity and make dogs susceptible to papillomavirus infection. To address this issue, we propose to identify the canine papillomaviruses responsible for these infections, to evaluate the time at which dogs are infected, and to develop prophylactic vaccines. The ultimate goal of our studies is to develop vaccines that will allow investigators to carry out medical research without being compromised by serious papillomavirus infections.