Emerging Papillomaviruses in Immunosuppressed Dogs

免疫抑制犬中新出现的乳头瘤病毒

• 批准号: 8725249
• 负责人: Richard Schlegel
• 金额: $ 41.23万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8725249
• 关键词: Address; Appearance; Benign; Biology; Biopsy; Bone Marrow Transplantation; Canis familiaris; Clinical; Cloning; Cutaneous; DNA Sequence; Dermatologic; Detection; Development; Drug Evaluation; Drug Kinetics; Ensure; Genome; Goals; Grant; Histology; Human; Human Papillomavirus; Immune System Diseases; Immune response; Immunity; Immunocompromised Host; Immunohistochemistry; Immunosuppression; Individual; Infection; Infection prevention; Investigation; L1 viral capsid protein; Laboratories; Lesion; Malignant Neoplasms; Medical Research; Medicine; Methods; Neurologic; Pain; Papilloma; Papillomavirus; Papillomavirus Infections; Pharmaceutical Preparations; Plasmids; Play; Process; Protocols documentation; Research Personnel; Role; Safety; Sampling; Skin Neoplasms; Study models; Techniques; Testing; Time; Toxicology; Vaccination; Vaccines; Viral; Virus Diseases; base; gene therapy; human disease; immunosuppressed; prevent; prophylactic; research study; screening; tumor; virus host interaction

DESCRIPTION (provided by applicant): Dogs play a central role in laboratory medicine, ranging from studies of toxicology and pharmacokinetics to genetic therapy and bone marrow transplantation. Emerging papillomavirus infections and the tumors that they induce are increasingly complicating the study of immunosuppressed dogs. Defective immune responses in dogs are primarily the consequence of studying new drugs for treating dermatologic, neurologic and immunologic diseases. In addition, pioneering experiments on bone marrow transplantation also interfere with normal host immunity and make dogs susceptible to papillomavirus infection. To address this issue, we propose to identify the canine papillomaviruses responsible for these infections, to evaluate the time at which dogs are infected, and to develop prophylactic vaccines. The ultimate goal of our studies is to develop vaccines that will allow investigators to carry out medical research without being compromised by serious papillomavirus infections.

描述(由申请人提供)：狗在实验室医学中发挥着核心作用，从毒理学和药代动力学研究到遗传治疗和骨髓移植。新出现的乳头瘤病毒感染及其引发的肿瘤使免疫抑制犬的研究变得越来越复杂。狗的免疫反应缺陷主要是研究治疗皮肤病、神经学和免疫学疾病的新药的结果。此外，骨髓移植的开创性实验也干扰了正常的宿主免疫，使狗容易受到乳头瘤病毒的感染。为了解决这个问题，我们建议确定导致这些感染的犬乳头瘤病毒，评估狗被感染的时间，并开发预防性疫苗。我们研究的最终目标是开发疫苗，使研究人员能够在不受严重乳头瘤病毒感染影响的情况下开展医学研究。

项目成果

Use of reprogrammed cells to identify therapy for respiratory papillomatosis.

• DOI: 10.1056/nejmoa1203055
• 发表时间: 2012-09-27
• 期刊: The New England journal of medicine
• 作者: Yuan H;Myers S;Wang J;Zhou D;Woo JA;Kallakury B;Ju A;Bazylewicz M;Carter YM;Albanese C;Grant N;Shad A;Dritschilo A;Liu X;Schlegel R
• 通讯作者: Schlegel R