1/2-Integrative Cognitive Affective Therapy for Binge Eating Disorder

描述（由申请人提供）：暴食症（BED）包括反复发作的不受控制的暴饮暴食，导致严重的痛苦和损害。BED也被认为是各种精神和医学问题的风险因素，包括抑郁、焦虑、生活质量受损、肥胖和许多负面的医疗结果。本研究提出比较一种新的BED治疗方法（integrated Cognitive- affective Therapy-BED, ICAT-BED）和一种基于证据的BED治疗方法（Cognitive Behavior Therapy-Guided Self- Help, CBTgsh）。BED参与者将被随机分配到两种治疗条件中的一种，他们将接受17周的门诊治疗。参与者将在基线、治疗结束和6个月随访时进行全面评估。此外，参与者将在基线、治疗结束和6个月的随访期间完成饮食行为、情绪和活动的生态瞬时评估（EMA）。参与者的治疗过程将被数字化记录，依从性评估小组将评估临床医生对治疗方案的遵守程度。结果将集中于暴食行为和核心饮食失调精神病理的减少，以及共病精神病理、治疗接受度、临床损害、消耗、体重指数和身体活动的减少。假设的暴饮暴食维持因素包括认知自我差异将作为潜在的治疗调节因素进行检查。本项目的数据将进一步阐明ICAT-BED的有效性，并将为基于瞬间情绪调节过程的BED的潜在概念模型提供测试。

DESCRIPTION (provided by applicant): Binge eating disorder (BED) involves recurrent episodes of uncontrolled overeating that cause significant distress and impairment. BED is also considered to be a risk factor for a variety of psychiatric and medical problems, including depression, anxiety, impaired quality of life, obesity, and numerous negative medical outcomes. The present study proposes to compare a new treatment for BED (Integrative Cognitive-Affective Therapy-BED; ICAT-BED) to an evidence based treatment for BED (Cognitive Behavior Therapy-Guided Self- Help; CBTgsh). BED participants will be randomized to one of the two treatment conditions, in which they will receive 17 weeks of outpatient treatment. Participants will be comprehensively assessed at baseline, end of treatment, and 6-month follow-up. In addition, participants will complete Ecological Momentary Assessments (EMA) of eating behavior, emotion, and activity at baseline, end of treatment, and 6-month follow-up. Participants' treatment sessions will be digitally recorded and teams of adherence raters will assess the degree to which clinicians adhered to the treatment protocols. Outcomes will focus on reductions in binge eating behavior and core eating disorder psychopathology, as well as comorbid psychopathology, treatment acceptance, clinical impairment, attrition, body mass index, and physical activity. Hypothesized binge eating maintenance factors including cognitive self-discrepancy will be examined as potential treatment moderators. Data from this project will further clarify the efficacy of ICAT-BED and will provide a test of an underlying conceptual model of BED based on momentary emotion regulation processes.