Neurobiological and Psychological Maintenance Mechanisms Associated with Anticipatory Reward in Bulimia Nervosa

与神经性贪食症预期奖励相关的神经生物学和心理维持机制

• 批准号: 9974812
• 负责人: CAROL B. PETERSON
• 金额: $ 19.25万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9974812
• 关键词: Adult; Affect; Affective; Aftercare; Amygdaloid structure; Behavior; Behavioral; Binge Eating; Bulimia; Chronic; Corpus striatum structure; Data; Down-Regulation; Ecological momentary assessment; Environment; Food; Food Selections; Frequencies; Functional Magnetic Resonance Imaging; Individual; Insula of Reil; Intervention; Investigation; Learning; Link; Maintenance; Medical; Methods; Negative Reinforcements; Neurobiology; Nucleus Accumbens; Participant; Patient Self-Report; Patients; Phase; Positive Reinforcements; Preparation; Procedures; Process; Reporting; Research; Rewards; Role; Symptoms; System; Time; Up-Regulation; cost; indexing; loss of control over eating; mortality risk; negative affect; negative mood; neglect; neural patterning; neuroimaging; novel; positive mood; psychologic; purge; relating to nervous system; response; reward anticipation

Abstract The purpose of this investigation is to identify the anticipatory reward mechanisms that maintain bulimic behavior in bulimia nervosa. Emerging data indicate the importance of reward and anticipatory processes as maintenance mechanisms of bulimia nervosa that can be targeted in existing and novel treatments. The proposed research will identify neurobiological and psychological anticipatory mechanisms of bulimic behavior using fMRI as well as ecological momentary assessment (EMA) in the natural environment. In this investigation, 60 adults (30 with bulimia nervosa and 30 comparison participants) will undergo negative and positive mood inductions followed by an fMRI food selection task (and a comparison shopping task) to examine neurobiological and affective responses to behavior anticipation. Because these anticipatory processes are hypothesized contributors to illness maintenance, duration of illness will be examined as a moderator. To examine the ecological validity of our fMRI results, participants with bulimia nervosa will complete two weeks of ecological momentary assessment (EMA) examining real-time affect changes in relation to the anticipation of bulimic behavior. These methods will facilitate rigorous assessment of the links between neurobiological (fMRI) and naturalistic (EMA) data in anticipatory reward processes. Findings from this investigation will inform the conceptualization and treatment of bulimia nervosa by identifying the role of reward anticipation in symptom maintenance, providing a crucial framework for targeting these anticipatory processes in the existing and novel interventions.

摘要 本研究的目的是确定维持暴食症的预期奖励机制 神经性贪食症的行为新出现的数据表明奖励和预期过程的重要性， 神经性贪食症的维持机制，可以在现有的和新的治疗目标。的 拟议的研究将确定暴食行为的神经生物学和心理预期机制 使用功能磁共振成像以及生态瞬时评估（EMA）在自然环境中。在这 在一项研究中，60名成年人（30名神经性贪食症患者和30名对照参与者）将接受阴性和 积极的情绪诱导，然后进行fMRI食物选择任务（和比较购物任务），以检查 对行为预期的神经生物学和情感反应。因为这些预期过程 假设疾病维持的贡献者，疾病持续时间将作为调节剂进行检查。到 检查我们的功能磁共振成像结果的生态有效性，神经性贪食症的参与者将完成两周的 生态瞬时评估（EMA）检查与预期相关的实时影响变化， 暴食行为这些方法将有助于严格评估神经生物学（功能磁共振成像） 和自然主义（EMA）数据在预期奖励过程。调查结果将告知 通过识别奖励预期在症状中的作用来认识和治疗神经性贪食症 维护，提供了一个关键的框架，针对这些预期的过程中，现有的和新的 干预措施。