Social cognitive impairment in frontotemporal degeneration and schizophrenia

额颞叶变性和精神分裂症的社会认知障碍

• 批准号: 8547832
• 负责人: BRADFORD C DICKERSON
• 金额: $ 20.88万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-19 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8547832
• 关键词: Affective; Anatomy; Area; Atrophic; Behavior; Behavioral; Biological Neural Networks; Biological Preservation; Brain; Brain region; Classification; Clinical Trials Design; Cognitive; Data; Data Collection; Development; Development Plans; Diagnosis; Diagnostic; Disease; Exhibits; Family member; Foundations; Friends; Frontotemporal Dementia; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Image; Impaired cognition; Impairment; Intervention; Interview; Knowledge; Life; Link; Location; Magnetic Resonance Imaging; Measures; Mediating; Mental disorders; Methods; Monitor; National Institute of Mental Health; Nature; Nerve Degeneration; Neurologist; Neurology; Outcome Measure; Patients; Pattern; Performance; Physiological; Population; Psychiatrist; Psychiatry; Questionnaires; Relative (related person); Research; Rest; Schizophrenia; Scientist; Severities; Structure; Symptoms; System; Techniques; Testing; Translations; Variant; Work; cerebral atrophy; cognitive function; executive function; impression; improved; inclusion criteria; informant; instrument; nervous system disorder; neuropsychiatry; neuropsychological; rehabilitation management; relating to nervous system; research clinical testing; social; social cognition; tool

DESCRIPTION (provided by applicant): Although social cognition dysfunction is a hallmark initial symptom of frontotemporal dementia (FTD) and schizophrenia, it has received relatively little systematic study in these disorders and the relationship between neurodegenerative and neuropsychiatric structural changes and brain activation patterns is only beginning to be explored. The primary goal of the proposed research is to use an integrated set of structural and functional MRI measures to define the anatomic and physiologic abnormalities underlying social cognition dysfunction in patients with frontotemporal dementia and schizophrenia with the further goal of improving the management and rehabilitation of these patients. In FTD and schizophrenia, quantitative volumetric MRI methods are capable of detecting differential neuroanatomic abnormality patters in relation to areas of cognitive dysfunction. Likewise, functional connectivity MRI (fcMRI) tools have revealed activity of specific regional brain networks associated with social cognition tasks. Therefore, our specific aims are (1) to develop an objective battery to assess social cognition in FTD and schizophrenia, (2) to investigate regional brain atrophy patterns associated with social cognitive impairment in patients with FTD and schizophrenia, and (3) to determine whether subtle social cognitive dysfunction is associated with functional abnormalities in brain networks associated with social cognition using resting-state functional MRI data and compare these findings to those related to regional atrophy patterns in FTD and schizophrenic patients. Across the neurodegenerative and neuropsychiatric diseases studied here, we hypothesize that social cognitive impairments will relate more to functional and structural abnormalities in networks subserving social cognition and less to diagnostic classification; that is, some patients with FTD or schizophrenia will have prominent social cognitive impairment and underlying brain abnormalities in networks subserving social cognition while some patients will have other types of symptoms with relative preservation of social cognition, supporting the recently conceived concept of common domains of cognitive-affective dysfunction across neuropsychiatric disorders.

描述（由申请人提供）：尽管社会认知功能障碍是额颞叶痴呆（FTD）和精神分裂症的标志性初始症状，但在这些疾病中接受的系统研究相对较少，神经退行性和神经精神结构变化与脑激活模式之间的关系才刚刚开始探索。拟议研究的主要目标是使用一套完整的结构和功能磁共振成像措施，以确定解剖和生理异常的额颞叶痴呆症和精神分裂症患者的社会认知功能障碍，进一步改善这些患者的管理和康复的目标。在FTD和精神分裂症中，定量容积MRI方法能够检测与认知功能障碍相关的不同神经解剖学异常模式。同样，功能连接MRI（fcMRI）工具揭示了与社会认知任务相关的特定区域大脑网络的活动。 因此，我们的具体目标是（1）开发一个客观的组合来评估FTD和精神分裂症患者的社会认知，（2）研究FTD和精神分裂症患者与社会认知障碍相关的局部脑萎缩模式，以及（3）使用静息-静息状态来确定微妙的社会认知功能障碍是否与社会认知相关的脑网络中的功能异常相关。陈述功能性MRI数据，并将这些结果与FTD和精神分裂症患者的区域萎缩模式相关的结果进行比较。 在这里研究的神经退行性疾病和神经精神疾病中，我们假设社会认知障碍更多地与辅助社会认知的网络中的功能和结构异常相关，而与诊断分类相关性较小;也就是说，一些FTD或精神分裂症患者会有明显的社会认知障碍和潜在的社会认知网络异常，而一些患者会有其他类型的症状与社会认知的相对保存，支持最近构思的概念的共同领域的认知情感功能障碍的神经精神障碍。