Integrated Hamilton Storage System to Support the UMBioBank

支持 UMBioBank 的集成 Hamilton 存储系统

• 批准号: 8335016
• 负责人: ALAN R. SHULDINER
• 金额: $ 160.33万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2016-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8335016
• 关键词: Address; Adult; Amish; Basic Science; Cardiovascular Diseases; Clinical Research; Collection; Complex; DNA; Data; Diabetes Mellitus; Disease; Effectiveness; Equipment; Future; Genetic; Genomics; Genotype; Goals; Grant; Health Care Costs; Healthcare; Housing; Individual; Laboratories; Life; Link; Liquid substance; Maryland; Medical; Medicine; Names; Patient Care; Patients; Phenotype; Policies; Procedures; Process; RNA; Research; Resources; Retrieval; Risk; Sampling; Stroke; System; Technology; Translations; Universities; Variant; base; biobank; dosage; evidence base; genome sequencing; genome wide association study; improved; medical schools; programs; sample collection; trait

DESCRIPTION (provided by applicant): Healthcare is rapidly moving towards a "personalized medicine" approach, tailoring decisions and medical practices to individual patients, harnessing the power of genomic discoveries to determine the type of treatment, the dosage, and even prospectively predicting the risk of developing disease. As each patient is unique, customizing treatment based on that individual's genetic make-up will serve to improve the effectiveness of healthcare and ultimately cut healthcare costs through improved efficiencies. While easy for monogenic disorders, discovering the genetic basis for complex disorders is challenging. Genome-wide association studies employing large numbers of samples from well-characterized patients have unveiled more than 1000 loci associated with complex diseases and traits such as diabetes, cardiovascular disease and stroke to name a few. The University of Maryland's Personalized and Genomic Medicine Program was initiated in April 2011. The goal of this Program is to advance basic and clinical research discovery in personalized and genomic medicine and to implement evidence-based personalized medicine into patient care at the University of Maryland Medical System (UMMS). Toward this goal we have begun two major biobanking projects. The UMMS Biobank will collect samples from at least 100,000 patients linked to detailed phenotype data and the EMR over the next several years. The Amish Wellness Project aims to ascertain essentially all adult Amish living in Lancaster, PA, approximately 12,000 individuals. In addition, the University of Maryland School of Medicine (UMSOM) houses a variety of research sample collections that focus on specific diseases. Centralizing these Biobanks will create synergies between them and provide the framework to establish standardized practices to govern future banking efforts. To support existing collections and provide adequate space for banking new collections, we propose to support the UMBioBank with a fully automated system by Hamilton Storage Technologies that integrates storage with sample processing and automating procedures from genotyping of single variants to whole genome sequencing. The storage system will allow banking of 500,000 DNA samples, 75,000 buffy coats, and 50,000 RNA samples using a combination of -80¿C and -20¿C storage units, all linked to an automated liquid handling platform. The system will be housed in newly renovated space in a CLIA- and CAP-accredited laboratory, in space proximal to other clinical research laboratories, to facilitate use of banked samples. A management plan is presented that addresses policies for adding samples to the bank, and access to banked samples. The UMSOM and UMMS are providing substantial resources to support the UMBioBank. The goal of this grant is to acquire the essential equipment to establish the UMBioBank, specifically, to support sample collection, processing, DNA extraction, storage and sample retrieval to facilitate use and sharing of samples for discoveries in personalized and genomic medicine and their translation into improved patient care.

描述(由申请者提供)：医疗保健正迅速走向“个性化医疗”方法，为个别患者量身定做决策和医疗实践，利用基因组发现的力量来确定治疗类型、剂量，甚至前瞻性地预测疾病的发展风险。由于每个患者都是独一无二的，根据个人的基因构成定制治疗将有助于提高医疗保健的有效性，并最终通过提高效率来降低医疗成本。虽然单基因疾病很容易，但发现复杂疾病的遗传基础是具有挑战性的。全基因组关联研究使用了来自特征良好的患者的大量样本，揭示了1000多个与复杂疾病和特征相关的基因座，例如糖尿病、心血管疾病和中风。马里兰大学的个性化和基因组医学项目于2011年4月启动。该计划的目标是推动个性化和基因组医学的基础和临床研究发现，并将循证个性化医学应用于马里兰大学医疗系统(UMMS)的患者护理。为了实现这一目标，我们已经开始了两个主要的生物库项目。UMMS生物库将在未来几年收集至少10万名患者的样本，这些样本与详细的表型数据和EMR有关。阿米什健康项目旨在确定基本上所有居住在宾夕法尼亚州兰开斯特的成年阿米什人，大约有12,000人。此外，马里兰大学医学院(UMSOM)收藏了各种专注于特定疾病的研究样本。集中这些生物银行将在它们之间创造协同效应，并提供框架，以建立标准化做法，以管理未来的银行工作。为了支持现有的收集，并为储存新的收集提供足够的空间，我们建议用汉密尔顿存储技术公司的全自动化系统支持UMBioBank，该系统将存储与样本处理相结合，并实现从单个变种的基因分型到全基因组测序的自动化程序。该存储系统将允许储存500,000个DNA样本，75,000件浅黄色大衣和50,000个RNA样本，使用-80？C和-20？C存储单元的组合，所有这些都连接到一个自动液体处理平台。该系统将被安置在新装修的空间中，位于CLIA和CAP认证的实验室中，位于其他临床研究实验室附近的空间，以方便使用库存样本。提出了一项管理计划，该计划涉及将样本添加到银行和访问银行样本的政策。UMSOM和UMMS正在提供大量资源来支持UMBioBank。这笔赠款的目标是获得建立UMBioBank的必要设备，特别是支持样本收集、处理、DNA提取、存储和样本检索，以促进样本的使用和共享，以发现个性化和基因组医学，并将其转化为改进的患者护理。