Clinical Nutrition Research Unit of Maryland

马里兰州临床营养研究中心

• 批准号: 7665491
• 负责人: ALAN R. SHULDINER
• 金额: $ 104.34万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7665491
• 关键词: Clinical; Nutrition; Research; Unit; Maryland

DESCRIPTION, OVERALL (provided by applicant): The CNRU of Maryland will focus on the influence of nutrition and exercise on risk for age-related chronic diseases, including obesity, type 2 diabetes, hypertension, cardiovascular disease (CVD), sleep disordered breathing, and osteoporosis. With the obesity epidemic, associated co-morbidities now detract from the quality of life for the majority of Americans and represent a major burden to our health care system. Our research base brings together 44 investigators working on nutrition-related research at three institutions (University of Maryland, Johns Hopkins University, and U.S. Department of Agriculture, Beltsville), with multidisciplinary expertise and a strong track record of collaboration and NIH funding. To identify and evaluate the important genes that predict biological responses to diet (nutrigenomics) and exercise, our multidisciplinary research team utilizes the full spectrum of human genetics research from recruitment and phenotyping to high throughput molecular genetics to state-of-the-art statistical genetic analyses. Our team also has extensive experience in clinical and translational research, testing diet and exercise interventions to treat central obesity and the metabolic syndrome. Bridging genetics and clinical and translational research, a critical mass of investigators conduct basic research into the mechanisms regulating adipose tissue function. A cross-cutting theme of many research collaborations is understanding the genetic and nutritional contributors to high prevalence of obesity and its co-morbidities in minority populations, particularly African-Americans. Additionally, researchers address the genetic and environmental control of bone density and stroke risk and translational research to examine genetic and nutritional factors that increase risk of, and recovery from, hip fracture and stroke. The proposed Maryland CNRU will provide infrastructure and resources to expand the scope of our collaborative research efforts and to expedite new discoveries in nutrition-related research. The CNRU is organized into (Genetics; Interventions; Adipocyte Biology), (Genetics, Functional Genomics and Genetic Epidemiology; Clinical Research; Adipose Biology and Basic Mechanisms). We will also organize seminars, journal clubs, symposiums and other activities. The CNRU of Maryland will foster and facilitate research into critical issues in human nutrition and translate knowledge into effective therapies and interventions that address important health disparities in our population

总体描述（由申请人提供）： 马里兰州 CNRU 将重点研究营养和运动对与年龄相关的慢性疾病风险的影响，包括肥胖、2 型糖尿病、高血压、心血管疾病 (CVD)、睡眠呼吸障碍和骨质疏松症。随着肥胖的流行，相关的并发症现在降低了大多数美国人的生活质量，并成为我们医疗保健系统的主要负担。我们的研究基地汇集了来自三个机构（马里兰大学、约翰霍普金斯大学和美国农业部贝尔茨维尔）从事营养相关研究的 44 名研究人员，他们拥有多学科专业知识以及良好的合作记录和 NIH 资助。为了识别和评估预测对饮食（营养基因组学）和运动的生物反应的重要基因，我们的多学科研究团队利用全方位的人类遗传学研究，从招募和表型分析到高通量分子遗传学，再到最先进的统计遗传分析。我们的团队在临床和转化研究、测试饮食和运动干预措施以治疗中心性肥胖和代谢综合征方面也拥有丰富的经验。大量研究人员将遗传学与临床和转化研究联系起来，对调节脂肪组织功能的机制进行基础研究。许多研究合作的一个交叉主题是了解少数族裔（尤其是非裔美国人）肥胖率高及其合并症的遗传和营养因素。此外，研究人员还致力于骨密度和中风风险的遗传和环境控制，以及转化研究，以检查增加髋部骨折和中风风险和恢复的遗传和营养因素。拟议的马里兰 CNRU 将提供基础设施和资源，以扩大我们合作研究工作的范围，并加快营养相关研究的新发现。 CNRU 分为（遗传学；干预措施；脂肪细胞生物学）、（遗传学、功能基因组学和遗传流行病学；临床研究；脂肪生物学和基本机制）。我们还将组织研讨会、期刊俱乐部、座谈会和其他活动。马里兰州 CNRU 将促进和促进对人类营养关键问题的研究，并将知识转化为有效的疗法和干预措施，以解决我们人口中的重要健康差异