Olympus VS-120 Virtual Slide Scanning System

奥林巴斯 VS-120 虚拟载玻片扫描系统

• 批准号: 8448459
• 负责人: DONNA L HAMMOND
• 金额: $ 23.05万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-15 至 2014-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8448459
• 关键词: Affect; Alexander Disease; Animal Model; Animals; Benign; Cells; Child; Clinical; Computer software; Cystic Fibrosis; Databases; Dental Students; Development; Diagnostic; Disease; Education; Educational Grants; Family suidae; Ferrets; Funding; Grant; Health; Human; Image; Immune; Infant; Inflammation; Iowa; Laboratories; Lead; Learning; Lung; Lung nodule; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Medical Students; Microscope; Microscopy; Mus; Pancreas; Pathology; Patients; Phenotype; Physicians; Proteins; Quality of life; Research; Research Project Grants; Resources; Risk; Role; Scanning; Slide; Staging; Students; System; Testing; United States National Institutes of Health; United States National Library of Medicine; Universities; Update; Wound Healing; chronic pain; cost effectiveness; effective therapy; efficacy testing; gene therapy; graduate student; image reconstruction; improved; instrumentation; satisfaction; virtual

DESCRIPTION (provided by applicant): The virtual slide scanner and quantitative software is absolutely essential in allowing pathology truth to define imaging truth. We are funded through NIH grants to undertake this important task for lung and prostate cancer in the human. The proposed instrumentation, the Olympus VS120 slide-scanning microscope with VisioMorph newCAST software is critical for the completion of several very important NIH funded research projects and NIH funded educational grants at the University of Iowa. Some of the immediate applications include distinguishing malignant from benign lung nodules, 3D reconstruction imaging of mouse, ferret and pig lungs as a baseline for animal models in cystic fibrosis animals, defining the development of cystic fibrosis phenotype in the pancreas. The successful completion of Dr. Henry's research will lead to identification of patients at risk for lethal prostte cancer at stages early enough for effective treatment. Dr. Hammond seeks clarification of the role of inflammation in chronic pain leading to enhanced therapies for a higher quality of life for chronic pain patients. Dr. Dunnwald and Dr. Murray are analyzing the role of the protein Irf6 in immune cells associated with wound healing. Dr. Bonthius will test the efficacy of gene therapy against Alexander's disease, a disease with devastating and lethal affects on infants and children. The virtual slide scanner will also support the microscopy component of a current National Library of Medicine funded educational research and resource proposal that is aimed at increasing the efficiency and cost effectiveness of laboratory test ordering in clinical medicin. Updating and expanding the Virtual Slidebox for medical, dental and graduate students. The Virtual Slidebox increases accessibility, student satisfaction and efficiency of learning. This database is also used to assess the diagnostic competency of resident physicians. Enhanced medical student and resident education will continue to improve the lives and health of countless patients.

描述（由申请人提供）：虚拟载玻片扫描仪和定量软件在允许病理学事实定义成像事实方面绝对必要。我们通过美国国立卫生研究赠款来承担这项针对人类肺癌和前列腺癌的重要任务。拟议的仪器，奥林巴斯VS 120载玻片扫描显微镜与VisioMorph newCAST软件是至关重要的几个非常重要的NIH资助的研究项目和NIH资助的教育赠款在爱荷华州大学完成。一些直接的应用包括区分恶性和良性肺结节，小鼠、雪貂和猪肺的3D重建成像作为囊性纤维化动物动物模型的基线，定义胰腺囊性纤维化表型的发展。亨利博士的研究的成功完成将导致在足够早的阶段识别有致命前列腺癌风险的患者，以进行有效的治疗。哈蒙德博士寻求澄清炎症在慢性疼痛中的作用，从而加强治疗，提高患者的生活质量。 慢性疼痛患者Dunnwald博士和Murray博士正在分析Irf6蛋白在与伤口愈合相关的免疫细胞中的作用。Bonthius博士将测试基因疗法对亚历山大病的疗效，这种疾病对婴儿和儿童具有毁灭性和致命性的影响。 虚拟载玻片扫描仪还将支持目前国家医学图书馆资助的教育研究和资源提案的显微镜组成部分，该提案旨在提高临床医学实验室测试订购的效率和成本效益。更新和扩大虚拟幻灯片框为医学，牙科和研究生。虚拟幻灯片增加了可访问性，学生满意度和学习效率。该数据库还用于评估住院医师的诊断能力。加强医学生和住院医师教育将继续改善无数患者的生活和健康。