CityLab Promotes Understanding of Clinical Trials

项目摘要 CityLab是一个以实践探究为基础的生物技术实验室项目，成立于1991年 从那时起，已经为30多万名学生和3,000名教师提供了服务。CityLab有两个 波士顿大学医学院的专门实验室，随着其非常 成功的移动生物技术实验室(MobileLab)，我们现在教授我们的课程补充 每年大约有7000名初中生和高中生。CityLab已经成为一个成功的 为地方和国家改善大学前科学教育的努力树立了榜样。 CityLab现在寻求扩大其影响范围，向学生传授临床研究知识。在.期间 这个拟议的第一阶段/第二阶段项目，我们将开发一个新的课程补充，其中包括 动手实验室实验和计算机生成的模拟提供敏锐的 9-12年级学生对临床研究基本要素的理解和欣赏 还有他们的老师。为此，我们将扩展CityLab最成功的课程之一 题为《弯曲细胞的奥秘》的增刊。本副刊教导学生有关 导致镰状细胞性贫血的点突变，它通过让学生 进行血红蛋白电泳法。扩展这一课程补充内容，向学生传授 临床试验，学生将了解测试一种新的候选药物的重要性 通过重新激活编码镰状细胞病的基因来逆转镰状细胞病的临床表现 胎儿血红蛋白的形成。 将向学生介绍临床试验过程的几个关键要素，包括 将实验室科学转化为临床领域的重要性。临床研究阶段(I、II、 和iii)将通过模拟调查进行解释。特别是，学生将设计和 分析一个模拟的大型临床试验的数据，学生们将“挖掘”这些数据来展示他们的 调查结果。临床试验的其他重要方面，如保护患者权利、伦理、 知情同意，IRBs将被包括在内。 整个计划将扩大到包括家长、教师和整个社区。我们的 目标是让人们深刻地认识到公民参与临床试验和 临床试验产生的数据的重要性。由于这份原创的课程补充已经 虽然这一推广模式已被广泛采用，但其可行性已经确立。

Project Summary CityLab is a hands-on inquiry based biotechnology laboratory program that was organized in 1991 and has served more than 300,000 students and 3,000 teachers since that time. CityLab has two dedicated laboratories at Boston University School of Medicine and, with the development of its very successful mobile biotechnology laboratory (MobileLab), we now teach our curriculum supplements to approximately 7,000 middle and high school students per year. CityLab has become a successful model for both local and national efforts to improve pre-college science education. CityLab now seeks to expand its sphere of influence to teach students about clinical research. During this proposed Phase I/II project, we will develop a new curriculum supplement that includes both hands-on laboratory experiments and computer-generated simulations to impart a keen understanding and appreciation of the basic elements of clinical research to students in grades 9-12 and their teachers. To accomplish this, we will expand one of CityLab's most successful curriculum supplements entitled "The Mystery of The Crooked Cell". This supplement teaches students about the point mutation that is responsible for sickle cell anemia and it does so by engaging students to perform hemoglobin electrophoresis. To expand this curriculum supplement to teach students about clinical trials, students will learn about the importance of testing a novel drug candidate that may reverse the clinical manifestations of sickle cell disease by reactivating the gene that codes for the formation of fetal hemoglobin. Students will be introduced to several critical elements of the clinical trial process including the importance of translating bench science into the clinical arena. The clinical investigation phases (I, II, and III) will be explained through simulated investigations. In particular, students will design and analyze data from a simulated large clinical trial and students will "mine" the data to present their findings. Other important aspects of clinical trials such as the protection of patient rights, ethics, informed consent, and IRBs will be included. The entire program will be expanded to include parents, teachers and the community at large. Our goal is to impart a deep appreciation of the importance of citizen participation in clinical trials and the importance of the data generated by a clinical trial. Since this original curriculum supplement has been widely adopted, the viability of this outreach model is well established.