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CityLab Promotes Understanding of Clinical Trials

CityLab 促进对临床试验的理解

基本信息

批准号：
8306772
负责人：
DONALD A DEROSA
金额：
$ 26.36万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-28 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8306772
关键词：
Academia Address Adopted Adult Award Biology Biotechnology Boston Cells Clinical Clinical Research Clinical Trials Code Communities Computer Analysis Computers Conduct Clinical Trials Data Data Analyses Development Education Education and Outreach Educational Curriculum Educational process of instructing Educational workshop Effectiveness Electrophoresis Elements Enrollment Ethical Issues Ethics Evaluation Exercise Fetal Hemoglobin Fostering Future Genes Goals Government Health Policy Hemoglobin Human Individual Industry Informed Consent Institutional Review Boards Internet Intervention Investigation Knowledge Laboratories Learning Life Style Link Location Manuals Medical Medical center Methods Mission Modeling Molecular Molecular Biology National Center for Research Resources Nature Parents Participant Patient Rights Patients Perception Phase Pilot Projects Point Mutation Process Public Health Reading Research Personnel Resources Reticulocytes Rights Role Sampling School Teachers Schools Science Scientist Secondary Schools Secure Sickle Cell Anemia Simulate Students Testing Thinking Time Translating Translational Research United States National Institutes of Health Universities Visit Waiting Lists Work base career college computer generated data mining design drug candidate drug discovery drug efficacy elementary school experience health application high school human subject protection improved innovation insight interest knowledge base literacy medical schools member middle school novel outreach post intervention programs research study science education simulation sound success teacher university student

项目摘要

Project Summary CityLab is a hands-on inquiry based biotechnology laboratory program that was organized in 1991 and has served more than 300,000 students and 3,000 teachers since that time. CityLab has two dedicated laboratories at Boston University School of Medicine and, with the development of its very successful mobile biotechnology laboratory (MobileLab), we now teach our curriculum supplements to approximately 7,000 middle and high school students per year. CityLab has become a successful model for both local and national efforts to improve pre-college science education. CityLab now seeks to expand its sphere of influence to teach students about clinical research. During this proposed Phase I/II project, we will develop a new curriculum supplement that includes both hands-on laboratory experiments and computer-generated simulations to impart a keen understanding and appreciation of the basic elements of clinical research to students in grades 9-12 and their teachers. To accomplish this, we will expand one of CityLab's most successful curriculum supplements entitled "The Mystery of The Crooked Cell". This supplement teaches students about the point mutation that is responsible for sickle cell anemia and it does so by engaging students to perform hemoglobin electrophoresis. To expand this curriculum supplement to teach students about clinical trials, students will learn about the importance of testing a novel drug candidate that may reverse the clinical manifestations of sickle cell disease by reactivating the gene that codes for the formation of fetal hemoglobin. Students will be introduced to several critical elements of the clinical trial process including the importance of translating bench science into the clinical arena. The clinical investigation phases (I, II, and III) will be explained through simulated investigations. In particular, students will design and analyze data from a simulated large clinical trial and students will "mine" the data to present their findings. Other important aspects of clinical trials such as the protection of patient rights, ethics, informed consent, and IRBs will be included. The entire program will be expanded to include parents, teachers and the community at large. Our goal is to impart a deep appreciation of the importance of citizen participation in clinical trials and the importance of the data generated by a clinical trial. Since this original curriculum supplement has been widely adopted, the viability of this outreach model is well established.

项目总结