Mystery of the Crooked Cell 2.0: CityLab's Next Generation SocioscientificApproach to Gene Editing

弯曲细胞之谜 2.0：CityLab 的下一代基因编辑社会科学方法

• 批准号: 10745382
• 负责人: DONALD A DEROSA
• 金额: $ 27.08万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-03 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745382
• 关键词: Mystery; Crooked; Cell; 2.0; CityLab

Project Summary/Abstract Boston University School of Medicine’s new SEPA project, entitled "Mystery of the Crooked Cell 2.0: CityLab’s Next Generation Socioscientific Approach to Gene Editing," addresses the imperative that NIH's pre-college activities focus on biomedical workforce preparedness, especially for underrepresented minorities (URM). This project will reach close to 600 local URM students and, through planned dissemination, will reach thousands of students. CityLab is partnering with five Boston-area high schools and two afterschool STEM/health professions enrichment programs to test the effectiveness of embedding a focus on socioscientific reasoning (SSR) to promote understanding of gene editing. An SSR approach places science content in a meaningful social context and motivates students to take ownership of their learning. SSR skills include realizing the complexity of the content and context of an issue, analyzing an issue from multiple perspectives, seeking out sources of bias in data, and considering how and whether scientific investigations can advance understanding of an issue. This project will expand CityLab’s “Mystery of the Crooked Cell” hands-on, inquiry-based curriculum supplement that focuses on the molecular basis of sickle cell disease (SCD) by incorporating state-of-the-art gene editing content that is suffused with SSR. The new curriculum supplement, Mystery of the Crooked Cell 2.0 (MCC 2.0), will seamlessly integrate three elements: CityLab’s curriculum storyline and laboratory experiences, computer simulations of molecular biology assays developed at University of Wisconsin-River Falls, and immersive virtual reality simulations of gene editing for SCD therapies developed at UC Berkeley Innovative Genomics Institute. SSR will be embedded throughout MCC 2.0, as will awareness of STEM/biomedical science careers. CityLab will also build NextGen Scholars, a learning community that will not only engage students in advanced science content and lab applications using SSR but also foster attitudes that support equity and diversity in STEM. This project will demonstrate the feasibility and replicability of this pedagogical strategy; CityLab will then disseminate the curriculum widely and thereby sow the seeds for a diverse and inclusive future STEM workforce. The major objectives of the proposed project are: (1) to create MCC 2.0 in collaboration with high school teachers and students, (2) to build a diverse community of learners who use SSR to explore advanced science topics while gaining insights into the importance of diversity, equity, inclusion, and social justice in science, health, and society, (3) to examine changes in students’ science content understanding, SSR skills, science learner identity, and attitudes towards diversity in the biomedical sciences and medicine, (4) to track student participants through college to understand the broader impact of this approach, and (5) to earn designation as one of the first “High- Quality Design” high school lessons that are aligned to the Next Generation Science Standards (NGSS). This new SEPA initiative is a unique way to pilot, refine, and disseminate a first-of-its-kind science education program that will increase the diversity of the STEM/biomedical science workforce.

项目总结/摘要 波士顿大学医学院的新SEPA项目，题为“弯曲细胞2.0之谜：城市实验室的 下一代基因编辑的社会科学方法，“解决了NIH的大学预科教育的必要性， 活动的重点是为生物医学劳动力做好准备，特别是为代表性不足的少数群体做好准备。这 该项目将覆盖近600名当地的城市资源管理学生，并通过有计划的传播，将覆盖数千名 学生CityLab与波士顿地区的五所高中和两所课后STEM/健康专业合作 丰富计划，以测试嵌入社会科学推理（SSR）的有效性， 促进对基因编辑的理解。SSR方法将科学内容置于有意义的社会背景中 并激励学生对自己的学习拥有自主权。SSR技能包括认识到 问题的内容和背景，从多个角度分析问题，寻找偏见的来源， 数据，并考虑科学调查如何以及是否可以促进对问题的理解。 这个项目将扩展CityLab的“弯曲细胞之谜”动手，探究式课程补充 该项目通过整合最先进的基因编辑技术， 充满SSR的内容。新的课程补充，弯曲细胞之谜2.0（MCC 2.0）， 将无缝集成三个元素：CityLab的课程故事情节和实验室经验，计算机 威斯康星大学福尔斯分校开发的分子生物学分析模拟，以及沉浸式虚拟 在加州大学伯克利分校创新基因组学研究所开发的SCD疗法的基因编辑现实模拟。 SSR将嵌入整个MCC 2.0，以及对STEM/生物医学科学职业的认识。CityLab 还将建立NextGen学者，一个学习社区，不仅让学生参与先进的科学 此外，它还有助于培养支持STEM公平和多样性的态度。这 项目将展示这一教学策略的可行性和可复制性;城市实验室随后将传播 因此，我们必须广泛地推广课程，从而为未来多元化和包容性的STEM劳动力播下种子。 本计划的主要目标为：（1）与中学教师合作，创建MCC 2.0 和学生，（2）建立一个多元化的学习者社区，他们使用SSR来探索先进的科学主题 同时深入了解多样性，公平，包容和社会正义在科学，健康和发展中的重要性。 社会，（3）考察学生对科学内容的理解，SSR技能，科学学习者身份， 以及对生物医学科学和医学多样性的态度，（4）通过以下方式跟踪学生参与者： 大学了解这种方法的更广泛的影响，（5）赢得指定为第一个“高- 质量设计”高中课程，是对齐的下一代科学标准（NGSS）。 这项新的SEPA倡议是一种独特的方式来试点，完善和传播的第一个同类科学教育 该计划将增加STEM/生物医学科学劳动力的多样性。