Mutant Mouse Resource and Research Center

描述(申请人提供)：转基因小鼠(转基因、基因敲除和基因敲入)对几乎所有的医学领域都是无价的。由于创业板在了解人类发育和疾病以及创造改进的药物和疗法方面的重要性，在过去十年里创造了数万个创业板。MMRRC为生物医学社区提供独特的储存库服务，以进口、储存和分发大量宝石作为生物医学社区的资源。自从MMRRC网络在1999/2000年作为一个初出茅庐的储存库成立以来，它已经发展成为生物医学界的主要资源，其能力和小鼠品系和胚胎干细胞的组合清单超过了世界各地其他小鼠储存库的容量。这项提议的总体目标是继续并扩大密苏里大学突变小鼠区域资源中心(MMRRC)的这些功能和能力，为生物医学研究人员提供他们研究所需的小鼠模型和相关试剂。

DESCRIPTION (provided by applicant): Genetically-engineered mice (transgenics, knockout and knock-ins) have become invaluable to almost all fields of medicine. Because of the importance of GEM to understanding human development and diseases and to creating improved drugs and therapeutics, tens of thousands of GEM have been created over the last decade. The MMRRC provides a unique repository service to the biomedical community for importing, storing and distributing a vast number of GEM as a resource for the biomedical community. Since the MMRRC Network began as a fledging repository in 1999/2000, it has evolved into a major resource for the biomedical community with capabilities and a combined inventory of mouse lines and embryonic stem (ES) cells that exceeds the capacity of other mouse repositories worldwide. The overall goal of this proposal is to continue and expand these functions and capabilities of the Mutant Mouse Regional Resource Center (MMRRC) at the University of Missouri to provide biomedical investigators with the mouse models and related reagents they require for their research.