Mentoring and Research in Mouse Pathobiology

小鼠病理学的指导和研究

基本信息

批准号：
7239637
负责人：
CRAIG L FRANKLIN
金额：
$ 10.41万
依托单位：
UNIVERSITY OF MISSOURI-COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-20 至 2009-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7239637
关键词：
A/J Mouse Address Animal Experimentation Animal Model Animals Antigen-Presenting Cells Attention Award Bacteria Biology Biomedical Research CD4 Positive T Lymphocytes Cells Chronic Chronic Disease Condition Congenic Mice Data Development Diagnostic Diarrhea Disease Disease model Educational process of instructing End Point Endocrinology Environment Estrogen Receptor alpha Estrogen Receptors Estrogens Etiology Exhibits Explosion Female Gastrointestinal Diseases Genetic Genetic Models Genetically Engineered Mouse Goals Gonadal Steroid Hormones Grant Growth Helicobacter hepaticus Human Immune Immune response Immunology Immunosuppression Immunosuppressive Agents Inbred Strain Individual Infectious Disease Immunology Inflammation Inflammatory Inflammatory Bowel Diseases Inflammatory disease of the intestine Interferons Intestinal Mucosa Investigation Knockout Mice Laboratories Large Intestine Lead Mediating Medicine Mentors Microscopic Colitis Missouri Modeling Molecular Mucositis Mus Mutant Strains Mice Pathogenesis Pathologic Pathology Pattern Phase Prevention Principal Investigator Production Qualifying Receptor Signaling Research Research Personnel Research Training Resources Role Science Scientist Services Sex Bias Signal Transduction Testosterone Therapeutic Therapeutic immunosuppression Time Training Training Programs Typhlitis United States National Institutes of Health Universities base career cell type comparative cytokine disease phenotype experience improved male microorganism antigen model development mouse model mutant next generation novel novel therapeutics pathogen skills theories therapeutic target

项目摘要

DESCRIPTION (provided by applicant): With the explosion of genetically engineered mouse models, there are enormous opportunities for mouse pathobiologists in biomedical research. The Principal Investigator's career objectives are to become a more independent and successful mouse pathobiology researcher and to use existing skills as well as those developed through this proposal to mentor the next generation of mouse pathobiologists. His growth as a scientist has been hindered by time constraints associated with service, administrative and teaching responsibilities. This award will provide release from some of these responsibilities and redistribution of time in others so that he will have more focused and intensive research time. The candidate is very well qualified for this award by virtue of his extensive background in training and pathology, his experience in both independent and collaborative research and his environment which facilitates and promotes mouse pathobiology research and training. This environment includes a Comparative Medicine Training Program, a world-renowned Research Animal Diagnostic Laboratory, a Comparative Medicine Research Center and one of four Mutant Mouse Regional Resource Centers. Long-term research goals include unraveling the mechanisms of chronic intestinal inflammatory disease so that ultimately novel prevention and treatment strategies can be developed. The objectives of this proposal focus on differences seen between males and females in inflammatory diseases of the intestinal mucosa. The following specific aims will be employed in pursuit of these objectives: 1) determine what cell types characterize mucosal inflammation caused by H. hepaticus in the A/J mouse 2) assess the role of the gonadal steroid hormones, estrogen and testosterone, in pathogenesis of bacterial initiated mucosal inflammation and 3) assess the role of estrogen signaling of immune cells via estrogen receptor alpha (ERe0 and beta (ERL3) in mucosal inflammation. These projects will provide an ideal forum for the training of individuals in mouse pathobiology and enable them to initiate careers in research and become leaders in this field.

描述（由申请人提供）：随着基因工程小鼠模型的爆炸，小鼠病理生物学家在生物医学研究中有巨大的机会。主要研究者的职业目标是成为一名更独立和成功的老鼠病理生物学研究人员，并使用现有技能以及通过该建议开发的技能来指导下一代小鼠病原体医生。与服务，行政和教学责任相关的时间限制阻碍了他作为科学家的成长。该奖项将从其中一些责任和其他时间重新分配中释放出来，以便他将拥有更加专注和密集的研究时间。候选人凭借其广泛的培训和病理学背景，在独立和协作研究方面的经验以及他的环境，促进和促进了老鼠病理生物学研究和培训的环境，因此候选人非常有资格获得该奖项。该环境包括一个比较医学培训计划，世界知名的研究动物诊断实验室，一个比较医学研究中心以及四个突变的小鼠区域资源中心之一。长期的研究目标包括阐明慢性肠道炎症性疾病的机制，以便最终可以开发出新的预防和治疗策略。该提案的目标集中在肠粘膜炎症性疾病中男性和女性之间看到的差异。将采用以下特定目的来追求这些目标：1）确定哪些细胞类型是h. h. h. h. h. h. h. h. h. h. hepation在A/J鼠标中引起的粘膜炎症的表征2）评估雌激素，雌激素，雌激素，睾丸激素，睾丸激素，睾丸激素，睾丸激素的病原体在细菌启动炎症的病原体中，通过粘膜炎症和3）评估cander的作用（3）评估candy intune的作用，并评估candy的作用。（ERL3）在粘膜炎症中。